Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders PDF Download
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Author: Susanna Pietropaolo
Publisher: Cambridge University Press
ISBN: 131606140X
Category : Science
Languages : en
Pages : 471
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Book Description
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Susanna Pietropaolo
Publisher: Cambridge University Press
ISBN: 131606140X
Category : Science
Languages : en
Pages : 471
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Book Description
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Susanna Pietropaolo
Publisher:
ISBN: 9781316073216
Category : NATURE
Languages : en
Pages : 472
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Book Description
A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.
Author: Wim E. Crusio
Publisher: Cambridge University Press
ISBN: 1107044456
Category : Psychology
Languages : en
Pages : 471
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Book Description
A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.
Author: Wim E. Crusio
Publisher: Cambridge University Press
ISBN: 1107355575
Category : Science
Languages : en
Pages : 361
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Book Description
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Fergus Craik
Publisher: Psychology Press
ISBN: 1317775066
Category : Psychology
Languages : en
Pages : 776
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Book Description
The chapters in this volume are the edited versions of invited addresses to the XXVI International Congress of Psychology held in Montréal in August 1996. As one major goal of the Congress was to promote communication among specializations in scientific psychology, the speakers were asked to survey their research area and present their own work in a way that would be accessible to their colleagues in other areas. Another purpose of the meeting was to bring researchers together from different parts of the world, reflecting their different approaches to the scientific study of mind, brain, and behavior. Consequently, the eminent researchers who have written the twenty-six chapters included in the present volume were drawn from universities and research institutes in North America, Europe, Japan, Russia, Israel, and New Zealand. The chapters cover a range of topics in human and animal experimental psychology. The first section deals with psychobiological processes - the interplay of body and mind in determining intelligence, stress, and pain. The next five chapters address current issues in neuropsychology and neuroscience, including the neural correlates of attention and vision. A third section looks at learning processes in humans and animals, and a fourth deals with a range of topics in perception and cognition. The final five chapters take a developmental perspective, presenting theoretical and empirical analyses of the acquisition of perceptual and cognitive abilities. Overall, the collection illustrates the growing trend to break down traditional barriers between areas of experimental psychology; there are many instances of profitable interactions between researchers studying aspects of behavior and those studying the biological bases of these behaviors. The twenty-six chapters give an excellent overview of current research in scientific psychology.
Author: Wim E. Crusio
Publisher: Elsevier
ISBN: 0080536867
Category : Psychology
Languages : en
Pages : 994
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Book Description
The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.
Author:
Publisher:
ISBN:
Category : Schizophrenia
Languages : en
Pages : 602
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Book Description
Author: Stefan M Brudzynski
Publisher: Academic Press
ISBN: 0128097736
Category : Science
Languages : en
Pages : 582
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Book Description
Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals' internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study. - Represents a multidisciplinary approach that incorporates evolution, communication, behavioral homeostasis, emotional expression and neuropsychiatric dysfunction - Provides a systematic review of ultrasonic vocalizations in major groups of rodents widely used in laboratory research - Discusses numerous other species across vertebrates that emit ultrasounds
Author: Robert T. Gerlai
Publisher: Academic Press
ISBN: 0128041161
Category : Science
Languages : en
Pages : 710
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Book Description
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts
Author: Michael L. Alosco
Publisher: Oxford University Press
ISBN: 0190664142
Category : Psychology
Languages : en
Pages : 904
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Book Description
The prevalence of adult cognitive disorders will dramatically rise over the next 25 years due to the aging population. Clinical research on adult cognitive disorders has rapidly evolved, including evidence of new adult cognitive disorders and greater insight into the clinical presentation, mechanism, diagnosis, and treatment of established diseases. The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume covering most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. Topics covered include normal cognitive and brain aging, the impact of medical disorders and psychiatric illnesses on cognitive function, adult neurodevelopmental disorders, and various neurological conditions. This Handbook also provides a section on unique perspectives and special considerations for clinicians and clinical researchers, covering topics such as cognitive reserve, genetics, diversity, and neuroethics. Readers will be able to draw upon this volume to facilitate clinical practice (including differential diagnosis, treatment recommendations, assessment practices), and to obtain an in-depth review of current research across a wide spectrum of disorders, provided by leaders in their fields. The Oxford Handbook of Adult Cognitive Disorders is a one-of a kind resource appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals.
