Neuroscience in the 21st Century PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Neuroscience in the 21st Century PDF full book. Access full book title Neuroscience in the 21st Century by Donald W. Pfaff. Download full books in PDF and EPUB format.
Author: Donald W. Pfaff
Publisher: Springer
ISBN: 9781493934737
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Author: Zafar Iqbal
Publisher: CRC Press
ISBN: 1351086901
Category : Science
Languages : en
Pages : 345
Get Book Here
Book Description
Axoplasmic transport is the intracellular movement of cellular components required for the maintenance and normal physiological functioning of neuronal cells. This book provides an up to date reference for both established investigators as well as for those entering in the field.This volume describes the history and methods of the study of transport and the involvement of energy, ions, calmodulin, microtubules and other cellular components in transport. It also discusses the transport of polypeptides, lipids, nucleic acids, neutrotransmitter containing components and various other particles in nerve fibres. A significant portion of this book is devoted to axoplasmic transport, regeneration and the relevance of transport in neurotropic functions are described in the alst four chapters, followed by a discussion on the mechanism of axoplasmic transport.
Author: Donald W. Pfaff
Publisher: Springer
ISBN: 9781493934737
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Author: Akihiko Takashima
Publisher: Springer Nature
ISBN: 9813293586
Category : Medical
Languages : en
Pages : 405
Get Book Here
Book Description
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Author: D. G. Weiss
Publisher: Springer Science & Business Media
ISBN: 3642857140
Category : Medical
Languages : en
Pages : 206
Get Book Here
Book Description
Cajal and contemporary scientists have laid the basis of the modem concepts of the organization of the nervous system: the cir cuits of the brain are made up of individual neurons which transfer information via specialized structures called synapses. Soma and den drites usually receive the inputs, then the signal is carried all along the axon to the target areas. To fulfIll this task several types of neurons have developed their unique geometry characterized by a large recep tive area (soma and dendrites) and an often very extensive distal branching with the axon terminals. The volume of cytoplasm which constitutes the neuronal periphery is often far larger than the cell body, where the synthetic machinery is located. It is one of the roles ofaxoplasmic transport to supply the periphery with proper material and to sustain the specialized structures necessary for the physiological activity of the neuron. Furthermore, it has become more and more clear that target areas also exert effects on the innervating neurons, and these effects are not only mediated via recurrent fibers. Synapses have been shown to be able to pick up material from the synaptic left which is then intra axon ally transported back to the cell body. This retrograde axoplasmic transport has therefore been recognized as another basic mechanism to convey signals from the periphery to the centre.
Author: Andrew J. Bean
Publisher: Elsevier
ISBN: 0080465897
Category : Science
Languages : en
Pages : 466
Get Book Here
Book Description
The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. - Provides a comprehensive examination of membrane/protein movement in neuronal function - Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease - Includes a focus on Molecular Mechanisms - Illustrated with color summary pictures - The only book examining protein trafficking and its functional implications, written by leaders in the field
Author: Sidney Ochs
Publisher: Cambridge University Press
ISBN: 9780521247429
Category : Medical
Languages : en
Pages : 452
Get Book Here
Book Description
Recent developments have extended our knowledge of the basic functions of nerves: notably, the demonstration of the mechanism within nerve fibers which transports a wide range of essential materials. In order to understand how this discovery occurred, it is necessary to examine its history. The story begins in ancient Greece when nerves were conceived of as channels through which animal spirits carried sensory impressions to the brain. As science developed, the discoveries of various physical and chemical agents supplanted the agency of animal spirits until the molecular machinery of transport was recognized. In this fascinating and complete history, Sidney Ochs begins with a chronological look at this path of discovery, followed in the second half by a thematic approach wherein the author describes the electrical nature of the nerve impulse, fiber form and its changes in degeneration and regeneration, reflexes, learning, memory and other higher functions in which transport participates.
Author: A. Baethmann
Publisher: Springer Science & Business Media
ISBN: 1468452037
Category : Science
Languages : en
Pages : 403
Get Book Here
Book Description
A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
Author: Kjell Fuxe
Publisher: Pergamon
ISBN:
Category : Medical
Languages : en
Pages : 624
Get Book Here
Book Description
Dynamics of Degeneration and Growth in Neurons ...
Author: A. Baethmann
Publisher: Springer Science & Business Media
ISBN: 9783211833131
Category : Medical
Languages : en
Pages : 136
Get Book Here
Book Description
Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation - mother nature's experiment - or hypothermia which is reported to induce cell swelling. Treatment issues deal also with thrombolysis and combination therapies, or with the clearance of adverse blood components - LDL/fibrinogen - by a novel procedure using heparin. Other highlights are discussing the specificities of pediatric vs. adult brain trauma, or the evolving role of the Apolipoprotein-E e4 gene in severe head injury. An update is also provided on an online assessment of the patient management during the pre- and early hospital phase in Southern Bavaria. The empirical observation of neuroworsening is analyzed in further details, whether this is a specificity autonomously driving the posttraumatic course. Finally, the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis.
Author: Brian R. MacIntosh
Publisher: Human Kinetics
ISBN: 9780736045179
Category : Medical
Languages : en
Pages : 436
Get Book Here
Book Description
Provides readers with a detailed understanding of the different facets of muscle physiology. Examines motoneuron and muscle structure and function. It is intended for those need to know about skeletal muscle--from undergraduate and graduate students gaining advanced knowledge in kinesiology to physiotherapists, physiatrists, and other professionals whose work demands understanding of muscle form and function.
