Author: Gorazd B. Stokin
Publisher:
ISBN:
Category : Alzheimer's disease
Languages : en
Pages : 7

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Book Description

Author: Suzanne De La Monte
Publisher: BoD – Books on Demand
ISBN: 9533076909
Category : Medical
Languages : en
Pages : 706

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Book Description
Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Author: Ghulam Md Ashraf
Publisher: Springer Nature
ISBN: 9811396361
Category : Medical
Languages : en
Pages : 293

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Book Description
This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.

Author: Ralph A. Nixon
Publisher: Springer Science & Business Media
ISBN: 1441967877
Category : Medical
Languages : en
Pages : 775

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Book Description
This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Author: Udai Pandey
Publisher: Frontiers Media SA
ISBN: 2832534368
Category : Science
Languages : en
Pages : 161

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Book Description

Author: José Juan Antonio Ibarra Arias
Publisher: Bentham Science Publishers
ISBN: 9815039482
Category : Science
Languages : en
Pages : 277

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Book Description
Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology. This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include: - Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions - Tau-targeted therapy in Alzheimer's disease - history and current state - Emerging nanotherapeutic strategies in Alzheimer's disease - Implication of dehydroepiandrosterone on dementia related to oxidative stress - Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Author: Claudia Duran-Aniotz
Publisher: Frontiers Media SA
ISBN: 2889746070
Category : Science
Languages : en
Pages : 265

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Book Description

Author: Dick F. Swaab
Publisher: Elsevier
ISBN: 0128199768
Category : Science
Languages : en
Pages : 544

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Book Description
The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus. Reviews the anatomy and physiology of the anterior hypothalamus Provides cytoarchitecture and chemoarchitecture from rodents Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood Covers how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus Explores the role of the hypothalamus in sexual behavior and gender identity

Author:
Publisher: World Scientific
ISBN: 9814719811
Category : Health & Fitness
Languages : en
Pages : 1545

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Book Description
"This book provides an all-embracing review of each and every author's study on the related topics and areas. For instance, some author's study on Chinese Medicine, and some other researchers' survey on biomedical engineering. Moreover, there are also papers that focus on information based bioinformatics, pharmacy and medicinal chemistry and biopharmaceutical technology."--

Author: Hirokawa
Publisher: CRC Press
ISBN: 9780849377419
Category : Science
Languages : en
Pages : 360

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Book Description
This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.