Asymmetric Synthesis Mediated by Chiral Lithium Amides PDF Download
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Author: Johan Granander
Publisher:
ISBN: 9789162866297
Category : Asymmetric synthesis
Languages : en
Pages : 65
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Book Description
Author: Johan Granander
Publisher:
ISBN: 9789162866297
Category : Asymmetric synthesis
Languages : en
Pages : 65
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Book Description
Author: Jane M. Paul
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: G.R. Stephenson
Publisher: Boom Koninklijke Uitgevers
ISBN: 9780751400496
Category : Language Arts & Disciplines
Languages : en
Pages : 454
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Book Description
Design of asymmetric synthesis. Nonlinear effects in enantioselective synthesis - asymmetric amplification. Chiral enolates. Optically active B-ketosulfoxides in asymmetric synthesis. Chiral aminals in asymmetric synthesis. Asymmetric deprotonation reactions using enantiopure lithium amide bases. Asymmetric Diels-Alder reactions. Asymmetric oxidiation. Transition metal catalysts for asymmetric reduction. Asymmetric hydroboration. Asymmetric hydrosilylation and hydroformylation. Asymmetric conjugate addition reactions. Stereoselective transformations mediated by chiral titanium complexes. Asymmetric synthesis using enzymes and whole cells. Asymmetric palladium catalysed coupling reactions. Palladium allyl pi-complexes in asymmetric synthesis. Worked examples in asymmetric synthesis design. Stoichiometric electrophilic pi-complexes in asymmetric synthesis.
Author: Jia Liu
Publisher:
ISBN:
Category : Aldehydes
Languages : en
Pages : 190
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Book Description
Author: Nicholas J. Goldspink
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Per I. Arvidsson
Publisher:
ISBN: 9789162834678
Category :
Languages : en
Pages : 101
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Book Description
Author: R.E. Gawley
Publisher: Elsevier
ISBN: 0080514774
Category : Science
Languages : en
Pages : 395
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Book Description
The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.
Author: Petra Rönnholm
Publisher:
ISBN: 9789163368257
Category :
Languages : en
Pages : 73
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Book Description
Author:
Publisher: Elsevier
ISBN: 0080552641
Category : Science
Languages : en
Pages : 337
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Book Description
Advances in Asymmetric Synthesis
Author: James Morrison
Publisher: Elsevier
ISBN: 0323145000
Category : Science
Languages : en
Pages : 593
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Book Description
Asymmetric Synthesis, Volume 3: Stereodifferentiating Addition Reactions, Part B presents intensive investigations in leading academic and industrial laboratories on stereodifferentiating addition reactions. This book is divided into eight chapters and begins with a comprehensive review of the formation of chiral metal enolates and their stereoselective alkylation reactions. These topics are followed by discussions on chiral Aldol addition reactions and the many variations of asymmetric synthesis that may be carried out using chiral oxazolines. A chapter describes the alkylation of chiral hydrazones, a process that yields chiral-substituted aldehydes and ketones. Other chapters explore a variety of cyclization processes that form carbon-carbon and carbon-heteroatom bonds. The last chapters deal with the asymmetric cycloadditions and sigma-tropic rearrangements. Synthetic chemists and researchers will find this book invaluable.
