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Author: Martin Fusek
Publisher: CRC Press
ISBN: 0429536003
Category : Medical
Languages : en
Pages : 324
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Book Description
Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.
Author: Martin Fusek
Publisher: CRC Press
ISBN: 0429536003
Category : Medical
Languages : en
Pages : 324
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Book Description
Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811025134
Category : Medical
Languages : en
Pages : 619
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Book Description
Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
Author: Michael N.G. James
Publisher: Springer Science & Business Media
ISBN: 9780306458095
Category : Science
Languages : en
Pages : 532
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Book Description
The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con tributed poster presentations that spanned the whole range of interest in aspartic proteinases.
Author: Sajal Chakraborti
Publisher: Elsevier
ISBN: 0323956882
Category : Science
Languages : en
Pages : 2974
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Book Description
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811061416
Category : Medical
Languages : en
Pages : 668
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Book Description
This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author: Jos Tournoy
Publisher: Leuven University Press
ISBN: 9789058675262
Category : Medical
Languages : en
Pages : 124
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Book Description
Author: Alan J. Barrett
Publisher: Elsevier
ISBN: 0080984150
Category : Science
Languages : en
Pages : 1182
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Book Description
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
Author: Proceedings of the National Academy of Sciences
Publisher: National Academies Press
ISBN: 030906645X
Category : Science
Languages : en
Pages : 286
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Book Description
Author: Charis M. Galanakis
Publisher: Academic Press
ISBN: 012817286X
Category : Technology & Engineering
Languages : en
Pages : 359
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Book Description
Proteins: Sustainable Source, Processing and Applications addresses sustainable proteins, with an emphasis on proteins of animal origin, plant-based and insect proteins, microalgal single cell proteins, extraction, production, the stability and bioengineering of proteins, food applications (e.g. encapsulation, films and coatings), consumer behavior and sustainable consumption. Written in a scientific manner to meet the needs of chemists, food scientists, technologists, new product developers and academics, this book addresses the health effects and properties of proteins, highlights sustainable sources, processes and consumption models, and analyzes the potentiality of already commercialized processes and products. This book is an integral resource that supports the current applications of proteins in the food industry, along with those that are currently under development. - Supports the current applications of proteins in the food industry, along with those that are under development - Connects the properties and health effects of proteins with sustainable sources, recovery procedures, stability and encapsulation - Explores industrial applications that are affected by aforementioned aspects
Author: David Sullivan
Publisher: Springer Science & Business Media
ISBN: 3540290885
Category : Medical
Languages : en
Pages : 447
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Book Description
Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.
