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Author: Harold S. Ginsberg
Publisher: Springer Science & Business Media
ISBN: 1468479350
Category : Medical
Languages : en
Pages : 620
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Book Description
The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .
Author: Harold S. Ginsberg
Publisher: Springer Science & Business Media
ISBN: 1468479350
Category : Medical
Languages : en
Pages : 620
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Book Description
The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .
Author: Marianne Wilhelmina van Maarschalkerweerd
Publisher:
ISBN:
Category : Viral cell transformation
Languages : en
Pages : 198
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Book Description
Author: W. Doerfler
Publisher: Springer Science & Business Media
ISBN: 3642694608
Category : Medical
Languages : en
Pages : 240
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Book Description
A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1094
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Book Description
Author: W. Doerfler
Publisher: Springer Science & Business Media
ISBN: 3642464947
Category : Medical
Languages : en
Pages : 269
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Book Description
Author: W. Doerfler
Publisher: Springer Science & Business Media
ISBN: 3642695493
Category : Medical
Languages : en
Pages : 116
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Book Description
Author: Walter Doerfler
Publisher: Springer Science & Business Media
ISBN: 3642794998
Category : Science
Languages : en
Pages : 291
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Book Description
For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigations in mammalian molecular biology. In this, the second of three volumes, the attention is turned to such topics as DNA replication, recombination and integration, and post-transcriptional control. The chapters have been written by an international group of leading experts in their respective fields of interest.
Author: Walter Doerfler
Publisher: John Wiley & Sons
ISBN: 3527613471
Category : Science
Languages : en
Pages : 194
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Book Description
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily "contaminated" with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract also of all mammalian organisms is constantly in contact with foreign DNA. So far, next to nothing is known about defense mechanisms in mammals against the intrusion of foreign DNA. At least in cells growing in culture, the uptake and genomic fixation by integration of foreign DNA can readily be demonstrated. For a number of reasons, the author has considered it important to investigate the phenomena and mechanisms involved in the interaction of foreign DNA with mammalian cells and organisms in detail.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1964
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 988
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Book Description
