Applications of Picosecond Light Pulses in Laser Ionization Mass Spectrometry PDF Download
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Author: Charles William Wilkerson
Publisher:
ISBN:
Category : Laser pulses, Ultrashort
Languages : en
Pages : 418
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Book Description
Author: Charles William Wilkerson
Publisher:
ISBN:
Category : Laser pulses, Ultrashort
Languages : en
Pages : 418
Get Book Here
Book Description
Author: S.L. Shapiro
Publisher: Springer Science & Business Media
ISBN: 3662225743
Category : Science
Languages : en
Pages : 397
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Book Description
Soon after the invention of the laser, a brand-new area of endeavour emerged after the discovery that powerful ultrashort (picosecond) light pulses could be extracted from some lasers. Chemists, physicists, and engineers quickly recognized that such pulses would allow direct temporal studies of extremely rapid phenomena requiring, however, development of revolutionary ultrafast optical and electronic devices. For basic research the development of picosecond pulses was highly important because experimentalists were now able to measure directly the motions of atoms and molecules in liquids and solids: by disrupting a material from equilibrium with an intense picosecond pulse and then recording the time of return to the equilibrium state by picosecond techniques. Studies of picosecond laser pulses-their generation and diagnostic tech niques-are still undergoing a fairly rapid expansion, but a critical review of the state of the art by experienced workers in the field may be a timely help to new experimentalists. We shall review the sophisticated tools developed in the last ten years, including the modelocked picosecond-pulse-emitting lasers, the picosecond detection techniques, and picosecond devices. Moreover, we shall outline the basic foundations for the study of rapid events in chemistry and physics, which have emerged after many interesting experiments and which are now being applied in biology. An in-depth coverage of various aspects of the picosecond field should be helpful to scientists and engineers alike.
Author: K.B. Eisenthal
Publisher: Springer Science & Business Media
ISBN: 9400964277
Category : Science
Languages : en
Pages : 361
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Book Description
With the development of lasers that can generate light 11 14 pulses ranging from 10- - 10- sec duration, and capable of 13 peak powers in excess of 10 watts scientists have been able to investigate the interactions of light with matter in a time and power domain not previously possible. These ultrashort laser pulses provide a powerful tool for the study of chemical phenomena at the most fundamental level. Many of the elementary processes of importance in chemistry including energy dissipa tion, molecular motions, structural and chemical changes occur on a very short time scale and thus require special approaches. Th~ use of ultrashort laser pulses to perturb and to probe systems of interest affords a direct approach to the time reso lution of very rapid chemical phenomena. It was recognition of the impact of these relatively new approaches to chemical phenomena that motivated NATO to sponsor a meeting on the applications of picosecond spectroscopy in chemistry. The primary aim of the NATO workshop was to gain some perspective on the status of the field in terms of present research activities, technological developments and if possible the difficult task of sensing future directions. The way we decided to approach these issues was to gather together the main contributors to the field, fortunately many of whom were able to attend, to present their work and to participate in what turned out to be lively discussions of the field.
Author: S.L. Shapiro
Publisher: Springer
ISBN: 9783662225752
Category : Technology & Engineering
Languages : en
Pages : 392
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Book Description
Soon after the invention of the laser, a brand-new area of endeavour emerged after the discovery that powerful ultrashort (picosecond) light pulses could be extracted from some lasers. Chemists, physicists, and engineers quickly recognized that such pulses would allow direct temporal studies of extremely rapid phenomena requiring, however, development of revolutionary ultrafast optical and electronic devices. For basic research the development of picosecond pulses was highly important because experimentalists were now able to measure directly the motions of atoms and molecules in liquids and solids: by disrupting a material from equilibrium with an intense picosecond pulse and then recording the time of return to the equilibrium state by picosecond techniques. Studies of picosecond laser pulses-their generation and diagnostic tech niques-are still undergoing a fairly rapid expansion, but a critical review of the state of the art by experienced workers in the field may be a timely help to new experimentalists. We shall review the sophisticated tools developed in the last ten years, including the modelocked picosecond-pulse-emitting lasers, the picosecond detection techniques, and picosecond devices. Moreover, we shall outline the basic foundations for the study of rapid events in chemistry and physics, which have emerged after many interesting experiments and which are now being applied in biology. An in-depth coverage of various aspects of the picosecond field should be helpful to scientists and engineers alike.
Author: Jing Zou
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
A new concept based on the Picosecond Infrared Laser (PIRL) has been introduced to selectively excite water to directly drive ablation of biological tissue faster than any competing energy dissipation process that could damage surrounding tissue. This thesis work showed that this mechanism can be exploited for a new form of spatially resolved mass spectrometry with the prospect of near instant biodiagnostics with mass spectroscopic sensitivity. The ion source for imaging mass spectrometer was based on PIRL ablation with an electrospray pick up source to entrain the ablated species. This hybrid Picosecond Infrared Laser Assisted Electrospray Ionization (PIR-LAESI) showed a limit of detection of 100 nM and a spatial resolution of ~ 100 Îźm, limited only by the current focusing optics. The longitudinal spatial resolution is approximately determined by the absorption depth. At the wavelengths of PIRL pulse, the light is absorbed within a few microns at the ablation threshold, resulting in removal of ~ 4 Îźm thick of material per pulse, which is the size of a single cell. Most importantly no additional treatment was needed as in Matrix Assisted Laser Desorption/Ionization (MALDI). Molecular images using PIR-LAESI for both plant and animal tissues could be collected directly and matched to optical images of the same region. The image quality was compared to nanosecond LAESI versions. Smaller crater size with PIR-LAESI was noted with similar molecular image quality, indicating PIR-LAESI a more sensitive approach with higher spatial resolution. The question is how far the sensitivity can be improved. In principle, single protein detections is possible if there is no thermal fragmentation as shown in this work. New direct in vacuum sample presentation to mass spectrometry should enable this ultimate limit to single molecular detection, using an electric field for ion separation. Molecular dynamics simulation on the ablation process driven by PIRL on ionic polymer water solutions revealed the effect of electric field cannot be observed in the early stage of plume expansion but that the polymers stay intact with shedding of the water solvation layers. These results illustrate that selective excitation of the water provides the desired ablation physics.
Author: Steven Michael Colby
Publisher:
ISBN:
Category :
Languages : en
Pages : 710
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Book Description
Author: Ralf Zimmermann
Publisher: John Wiley & Sons
ISBN: 3527335102
Category : Science
Languages : en
Pages : 448
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Book Description
Provides comprehensive coverage of laser-induced ionization processes for mass spectrometry analysis Drawing on the expertise of the leading academic and industrial research groups involved in the development of photoionization methods for mass spectrometry, this reference for analytical scientists covers both the theory and current applications of photo-induced ionization processes. It places widely used techniques such as MALDI side by side with more specialist approaches such as REMPI and RIMS, and discusses leading edge developments in ultrashort laser pulse desorption, to give readers a complete picture of the state of the technology. Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications starts with a complete overview of the fundamentals of the technique, covering the basics of the gas phase ionization as well as those of laser desorption and ablation, pulse photoionization, and single particle ionization. Numerous application examples from different analytical fields are described that showcase the power and the wide scope of photo ionization in mass spectrometry. -The first general reference book on photoionization techniques for mass spectrometry -Examines technologies and applications of gas phase resonance-enhanced multiphoton ionization mass spectrometry (REMPI-MS) and gas phase resonance ionization mass spectrometry (RIMS) -Provides complete coverage of popular techniques like MALDI -Discusses the current and potential applications of each technology, focusing on process and environmental analysis Photoionization and Photo-Induced Processes in Mass Spectrometry: Fundamentals and Applications is an excellent book for spectroscopists, analytical chemists, photochemists, physical chemists, and laser specialists.
Author: David L. Andrews
Publisher: Springer Science & Business Media
ISBN: 1461303370
Category : Science
Languages : en
Pages : 229
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Book Description
Here is the first graduate-level textbook to offer an introduction to the field of laser spectroscopy. Chapters cover a broad range of topics in detail, emphasizing the theoretical and experimental aspects of the field. This much-needed text will allow students to explore current research and gain an understanding of the analytical and industrial applications of laser spectroscopy.
Author: Mihai Stafe
Publisher: Springer Science & Business Media
ISBN: 3642409784
Category : Science
Languages : en
Pages : 241
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Book Description
The book introduces ‘the state of the art' of pulsed laser ablation and its applications. It is based on recent theoretical and experimental studies. The book reaches from the basics to advanced topics of pulsed laser ablation. Theoretical and experimental fundamental phenomena involved in pulsed laser ablation are discussed with respect to material properties, laser wavelength, fluence and intensity regime of the light absorbed linearly or non-linearly in the target material. The energy absorbed by the electrons leads to atom/molecule excitation, ionization and/or direct chemical bond breaking and is also transferred to the lattice leading to material heating and phase transitions. Experimental non-invasive optical methods for analyzing these phenomena in real time are described. Theoretical models for pulsed laser ablation and phase transitions induced by laser beams and laser-vapour/plasma interaction during the plume expansion above the target are also presented. Calculations of the ablation speed and dimensions of the ablated micro- and nano-structures are performed. The validity and required refinement of different models in different experimental conditions is provided. The pulsed laser deposition process which bases on collecting the ablated particles on a surface is analyzed in terms of efficiency and quality of the deposited films as a function of ambient conditions, target material, laser parameters and substrate characteristics. The interaction between the incident laser and the ablation plasma is analyzed with respect to its influence on the structures of the deposited films and its capacity to generate high harmonics and single attosecond pulses which are highly desirable in pump-probe experiments.
Author: Yoshihiro Deguchi
Publisher: Taylor & Francis
ISBN: 1439853398
Category : Science
Languages : en
Pages : 301
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Book Description
Tighter regulations of harmful substances such as NOx, CO, heavy metals, particles, emissions from commercial plants and automobiles reflect a growing demand for lowering the anthropogenic burdens on the environment. It is equally important to monitor controlling factors to improve the operation of industrial machinery and plants. Among the many me
