Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals PDF Download
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Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309458625
Category : Science
Languages : en
Pages : 423
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Book Description
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309458625
Category : Science
Languages : en
Pages : 423
Get Book Here
Book Description
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 030945865X
Category : Science
Languages : en
Pages : 423
Get Book Here
Book Description
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Author:
Publisher: Academic Press
ISBN: 0128137258
Category : Technology & Engineering
Languages : en
Pages : 1055
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Book Description
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Author: Mark G. Robson
Publisher: CRC Press
ISBN: 1000816095
Category : Medical
Languages : en
Pages : 400
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Book Description
Understanding risk to humans is one of the most important problems in environmental public health. Risk assessment is constantly changing with the advent of new exposure assessment tools, more sophisticated models, and a better understanding of disease processes. Risk assessment is also gaining greater acceptance in the developing world where major environmental problems exist. Developed in partnership with the Association of Schools of Public Health, this comprehensive text offers a thorough survey of risk assessment, management, and communications as these practices apply to public health. Key Features: Provides a practical overview of environmental risk assessment and its application by discussing the process and providing case studies and examples Focuses on tools and approaches used for humans in an environment involving potential chemical hazards Fully updated, the first part introduces the underlying principles and techniques of the field, and the second examines case studies in terms of different risk assessment scenarios Risk assessment is a core requirement for the MPH degree in environmental health Useful “stories” suitable for case studies
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309474183
Category : Technology & Engineering
Languages : en
Pages : 67
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Book Description
Between 1942 and 1975, the U.S. Army conducted tests on human subjects to study the effects of a variety of agents, including chemical warfare agents, biological agents, medications, vaccines, and other substances. The tests investigated the immediate or short-term health effects from acute exposure to understand vulnerabilities to attack. Whether the exposures could have resulted in long-term health consequences to the test subjects has been assessed periodically, and the Army is required to notify subjects of information relating to potential health effects associated with exposure to the test agents. Most recently, a 2016 court injunction directed the Army to provide test subjects with new information about potential long-term health effects associated with their exposures, and to provide medical care if an injury or illness could be attributed to their participation in an Army chemical or biological testing program. In support of the first requirement, the Army contracted a report, Assessment of Potential Long-Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances: Literature Review and Analysis (the Report), to determine whether new information published since 2006 should be provided to the veterans. At the request of the Army, the National Academies of Sciences, Engineering, and Medicine formed an ad hoc committee that was tasked with conducting an independent review of the Report. The committee assessed whether the Report appropriately identified potential long-term health effects that could have resulted from test exposures using an adequate weight-of-evidence approach. The general approach for evaluating agent- and outcome-specific associations as outlined in the Army Memorandum was also reviewed. An interim report of its overarching findings and their supporting evidence was prepared in February 2018. This final report provides additional detail about the basis of the committee's findings and recommendations. No new findings or recommendations have been added to this report.
Author:
Publisher: Academic Press
ISBN: 0128234679
Category : Medical
Languages : en
Pages : 580
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Book Description
Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Pharmacology series - Updated release includes the latest information on Endocrine-Disrupting Chemicals
Author: Jerome F. Strauss
Publisher: Elsevier Health Sciences
ISBN: 032381008X
Category : Medical
Languages : en
Pages : 1393
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Book Description
For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. - Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. - Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. - Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. - Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. - Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. - Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. - Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author: Charles A. Lewis, MD MPH
Publisher: Psy Press
ISBN:
Category : Medical
Languages : en
Pages : 810
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Book Description
This special edition of Neurodevelopment and Intelligence contains both Volumes One and Two. The set provides an understanding neurodevelopmental risks during fetal and early life, and of the things that can go awry that limit or hinder healthy brain development, leading to a loss of intellectual abilities or causing disabilities such as autism spectrum disorder. It should be of interest to anyone interested in brain health, preventive medicine, pediatrics, public health policy, present and prospective parents, and those planning on pregnancy and parturition. Herein, Dr. Lewis explains: How people got smarter for more than a century and and why the alternative title of the book is Swimming in a Poisoned Pond —The Looming Demise of Cognitive and Mental Health in America How any healthy child can be a genius with advanced planning All the nasty things in your home that cause brain damage The disgusting things in your water that harm the brain The prenatal vitamins that prevent autism How ADHD is a lifestyle disease The eight pillars of health and their effects on the brain What men can do to sire smarter children The environmental toxins that cause violent crime and suicide How to make your home safe for your child’s brain The role of gut bacteria on the brain How to make pregnancy safer for the fetal brain Foods that improve brain function Maternal life style factors that affect IQ The seven pillars of health and their effects on the brain What men can do to sire smarter children How to make your home safe for your child’s brain The role of gut bacteria on the brain The disruptive effects of sleep deprivation and sleep disordered breathing on brain development, and sleep hygiene for children The effects of stress on the brain and its functioning The harmful effects of poverty on the brain How noise and noise pollution harm brain development. How good public policy can give us a brighter future Foods that improve brain function and make us happy and engaged The effects of Exercise and Environmental Enrichment Kiss your genetic legacy goodbye! Why you will likely never be a grandparent if you don’t already have children How stress makes us stupid Why people are getting dumber even though we have better medical care and more access to education. Are we already too dumb to save ourselves from our mistakes? How psychopathic corporations, stupidity, and structural racism raid America’s wealth The book is a serious scientific exploration of neurodevelopment on which policy and personal behavior changes can be based to improve health, happiness, and intellectual curiosity. Section I section lays out an description of the Intelligence Quotient (IQ) and why it can used as a proxy for neurodevelopment. It explains IQ tests and other developmental scales scoring, and some of their limitations. The high metabolic cost of a large brain and the survival advantage provided by epigenetic adaptation to downsize the brain to the current environmental conditions is described, explaining why a less costly and less intelligent brain are adaptive to leaner times. An estimate is made for the average human IQ in full health and nutrition, (about two standard deviations above the current average, or an IQ of 130). A primer on inflammation is given. Section 2: discusses the impact of anemia and iron on brain development. Topics include: Hookworm, malaria, and infections. Most of this section discusses iron deficiency, iron supplementation in pregnancy and infancy, and the role other minerals and vitamins required for blood formation Section 3: Covers the role of iodine and thyroid hormone on neurodevelopment. The following chapters discuss thyroid hormone disruptors including fluoride and bromide, organohalogens, thyroid disrupting organic pollutants, organophosphates and other biocides, and foods and food additives that impact thyroid function Section 4 covers neurotoxic metals in the environment. The neurotoxic metals that most commonly impact brain health are discussed, including arsenic, lead, mercury, manganese. The impacts of cadmium and aluminum on fetal and infant health are reviewed. Toxic metal exposure during development most commonly occurs from water contamination, and Chapter 18 covers water filtration for removal of these toxins. Section 5 discusses the role of toxic metals, dietary factors, and the role of the intestinal microbiome on the causation and exacerbation of autism spectrum disorder. Evidence on the role of special diets for ASD is reviewed.The timing of the development of ASD is discussed; as it is essential to understanding which exposures are relevant and amenable to treatment. Section 6 discussed the generation of air pollution from combustion of fuels and the adverse impacts of it on brain health. Effects of Particulate matter (PM) on health, Alzheimer’s and Parkinson’s disease are reviewed, along with its effects on the premature birth of infants, neurodevelopment, IQ, and autism. Mitigation of risk is discussed. Section 7 outlines maternal factors that impact neurodevelopment and intelligence. The causes and effects of preterm birth and small for gestational age are explored, with a particular focus on environmental influences. Section 8 covers the effect of general health on neurodevelopment, including the impact of diet on the intestinal microbiome, exercise, sleep deprivation, sleep-disordered breathing, and explains the roll of lifestyle in ADHD. Section 9 discusses the effects of psychosocial stress on neurodevelopment and intellectual performance, and discusses the epigenetic effects of stress on brain development and behavior. The role of having a supportive social environment, a stimulating environment, and education on brain development, IQ an health are discussed. The effects of prenatal stress on the brain are reviewed. Other topics include the effect of stress and telomere length, the effects of poverty or domestic violence on IQ score, and the effects of stress on the hypothalamic-pituitary-adrenal axis and on the gut. The effects of noise on hearing, academic performance, and sleep are reviewed. The need to confront endemic stress as a societal norm is discussed.
Author: Philippa D. Darbre
Publisher: Academic Press
ISBN: 0128219882
Category : Medical
Languages : en
Pages : 536
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Book Description
**Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease** Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations - Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309499240
Category : Nature
Languages : en
Pages : 77
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Book Description
Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification.
