Apoptotic Cell Clearance in Health and Disease PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Apoptotic Cell Clearance in Health and Disease PDF full book. Access full book title Apoptotic Cell Clearance in Health and Disease by Estee Kurant. Download full books in PDF and EPUB format.
Author: Estee Kurant
Publisher: Frontiers Media SA
ISBN: 2889456889
Category :
Languages : en
Pages : 294
Get Book Here
Book Description
Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.
Author: Estee Kurant
Publisher: Frontiers Media SA
ISBN: 2889456889
Category :
Languages : en
Pages : 294
Get Book Here
Book Description
Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Get Book Here
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Christopher D. Gregory
Publisher: Springer
ISBN: 3319394061
Category : Medical
Languages : en
Pages : 260
Get Book Here
Book Description
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Author: Siamon Gordon
Publisher: John Wiley & Sons
ISBN: 1555819192
Category : Science
Languages : en
Pages : 892
Get Book Here
Book Description
The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.
Author: Kursad Turksen
Publisher: Springer
ISBN: 3319981463
Category : Science
Languages : en
Pages : 182
Get Book Here
Book Description
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.
Author: Dmitri V. Krysko
Publisher: Springer Science & Business Media
ISBN: 1402092938
Category : Medical
Languages : en
Pages : 449
Get Book Here
Book Description
Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning “devouring cells,” was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 “in recognition of their work on immunity.” At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters.
Author: Sandra Hodge
Publisher: Bentham Science Publishers
ISBN: 1608050203
Category : Lungs
Languages : en
Pages : 128
Get Book Here
Book Description
"This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book consists of 8 chapters which provide a full coverage of macrophage function in both healthy and chronically diseased lungs, "
Author: Harald Wajant
Publisher: Springer Science & Business Media
ISBN: 0387345736
Category : Medical
Languages : en
Pages : 169
Get Book Here
Book Description
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.
Author: Douglas R. Green
Publisher: Cambridge University Press
ISBN: 1139498738
Category : Science
Languages : en
Pages : 470
Get Book Here
Book Description
Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Author: Diane E. Griffin
Publisher: Springer Science & Business Media
ISBN: 3540273204
Category : Medical
Languages : en
Pages : 300
Get Book Here
Book Description
(will follow)
