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Author: C.K. Chu
Publisher: Elsevier
ISBN: 0080524540
Category : Science
Languages : en
Pages : 269
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Book Description
• Up-to-date review on the chemistry and biology of nucleosides • Modern synthetic methodology • Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.
Author: C.K. Chu
Publisher: Elsevier
ISBN: 0080524540
Category : Science
Languages : en
Pages : 269
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Book Description
• Up-to-date review on the chemistry and biology of nucleosides • Modern synthetic methodology • Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.
Author: C.K. Chu
Publisher: Elsevier
ISBN: 0080540368
Category : Science
Languages : en
Pages : 545
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Book Description
The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.
Author: Pedro Merino
Publisher: John Wiley & Sons
ISBN: 1118498100
Category : Science
Languages : en
Pages : 859
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Book Description
Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Author: Claire Simons
Publisher: CRC Press
ISBN: 1040211615
Category : Medical
Languages : en
Pages : 206
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Book Description
Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.An introduction to the chemistry of nucleoside mimetics, which combines carbohydrate, heterocyclic, and asymmetric synthesis, this book examines the diversity of nucleosides and the range of elegant chemistry involved. It emphasizes the importance of nucleosides as both therapeutic agents and as probes for studying biochemical processes.
Author: Evamarie Hey-Hawkins
Publisher: John Wiley & Sons
ISBN: 1119275555
Category : Science
Languages : en
Pages : 490
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Book Description
Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Author: Janet L Rideout
Publisher: Academic Press
ISBN: 032314053X
Category : Science
Languages : en
Pages : 340
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Book Description
Nucleosides, Nucleotides, and Their Biological Applications contains the proceedings of the Fifth International Round Table on Nucleosides, Nucleotides, and Their Biological Applications held at Research Triangle Park, North Carolina on October 20-22, 1982. Contributors focus on the biological applications of nucleosides and nucleotides, along with advances in synthetic chemistry. Topic range from fast-moving biochemical subjects such as the 2',5'-oligoadenylates and their relationship to interferons; adenosine and adenine nucleotide receptors; and nucleosides with selective antiviral action. This volume is organized into 11 chapters and begins with an overview of nucleosides that are used as antiviral agents and their mechanism of action, including idoxuridine, vidarabine, and trifluridine. The discussion then shifts to the chemical and biological properties of nucleosides of purines and ring analogs; 2'-fluoroarabinosyl pyrimidines and purine-like C-nucleosides; and the potential of 2',5'-oligoadenylates as chemotherapeutic agents. The reader is also introduced to receptors for adenosine and adenine nucleotides; the function of pyrrolo[2,3-d]pyrimidine nucleosides in polynucleotides; and unusual nucleoside synthons and oligonucleotide synthesis. A chapter on the synthesis of versatile C-nucleoside precursors and certain C-nucleosides concludes the book. This book will be of value to chemists, biologists, and those with an interest in nucleosides and nucleotides.
Author: D. J. Jeffries
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 614
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Book Description
Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.
Author: Anant R. Kapdi
Publisher: Elsevier
ISBN: 012811293X
Category : Science
Languages : en
Pages : 360
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Book Description
Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. - Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches - Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds - Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization - Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Author: Renilde Loeckx
Publisher: Leuven University Press
ISBN: 9461663978
Category : Medical
Languages : en
Pages : 188
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Book Description
The extraordinary story of scientists in East and West combatting HIV A small group of scientists were doggedly working in the field of antiviral treatments when the AIDS epidemic struck. Faced with one of the grand challenges of modern biology of the twentieth century, scientists worked across the political divide of the Cold War to produce a new class of antivirals. Their molecules were developed by a Californian start-up together with teams of scientists at the Rega Institute of KU Leuven and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences in Prague. These molecules became the cornerstone of the blockbuster drugs now used to combat and prevent HIV. Cold War Triangle gives an insight into the human face of science as it recounts the extraordinary story of scientists in East and West who overcame ideological barriers and worked together for the benefit of humanity.
Author: Gail Skowron
Publisher: Springer Science & Business Media
ISBN: 1597450855
Category : Medical
Languages : en
Pages : 536
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Book Description
A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.
