Alkaloid Synthesis Using N-acylpyridinium Salts as Building Blocks PDF Download
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Author: Dimitar Borissov Gotchev
Publisher:
ISBN:
Category :
Languages : en
Pages : 243
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Book Description
Keywords: acylpyridinium salt, total synthesis, ( - )--FR901483.
Author: Dimitar Borissov Gotchev
Publisher:
ISBN:
Category :
Languages : en
Pages : 243
Get Book Here
Book Description
Keywords: acylpyridinium salt, total synthesis, ( - )--FR901483.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
A study directed toward the total synthesis of the potent immunosuppressant ( - )-FR901483 was examined. Three approaches to the tricyclic core of the targeted molecule were investigated, utilizing Grignard addition to an N-acylpyridinium salt and quaternary center formation as the key synthetic steps. In the first route, a pivotal keto-aldehyde intermediate was needed to study an intramolecular pinacol coupling approach to the backbone of the title compound. In the second and third generation synthetic designs, an intramolecular 6-exo-tet epoxide opening was envisioned as a means of generating the azabicyclo ring system of the target. Three novel polyheterocyclic ketones were synthesized in a flexible manner in search for an asymmetric epoxidation catalyst of unfunctionalized trans-alkenes. The targeted compounds were derived via a regiospecific alkylation of 5-hydroxy-2-methylpyridine, followed by functional group manipulation and nitrogen atom cyclization.
Author: Eric F.V. Scriven
Publisher: Academic Press
ISBN: 0123852366
Category : Science
Languages : en
Pages : 583
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Book Description
Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. - Reviews tried and tested practical methods to help the reader select the best method for their research - Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative - Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 886
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Book Description
Author: Atta-ur Rahman
Publisher: Elsevier
ISBN: 0080537332
Category : Science
Languages : en
Pages : 865
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Book Description
Structure and Chemistry (Part E)
Author: Hans-Joachim Knoelker
Publisher: Springer Science & Business Media
ISBN: 3642255280
Category : Science
Languages : en
Pages : 268
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Book Description
Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 522
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Book Description
Author: V Prakash Reddy
Publisher: Newnes
ISBN: 044453749X
Category : Science
Languages : en
Pages : 331
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Book Description
Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. - Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds - Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways - Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry
Author: Kevin David Welch
Publisher:
ISBN:
Category :
Languages : en
Pages : 706
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Book Description
Author: Tadeusz Aniszewski
Publisher: Elsevier
ISBN: 0080475337
Category : Science
Languages : en
Pages : 325
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Book Description
Alkaloids, represent a group of interesting and complex chemical compounds, produced by the secondary metabolism of living organisms in different biotopes. They are relatively common chemicals in all kingdoms of living organisms in all environments. Two hundred years of scientific research has still not fully explained the connections between alkaloids and life.Alkaloids-Chemistry, Biological Significance, Applications and Ecological Role provides knowledge on structural typology, biosynthesis and metabolism in relation to recent research work on alkaloids. Considering an organic chemistry approach to alkaloids using biological and ecological explanation. Within the book several questions that persist in this field of research are approached as are some unresearched areas. The book provides beneficial text for an academic and professional audience and serves as a source of knowledge for anyone who is interested in the fascinating subject of alkaloids. Each chapter features an abstract. Appendices are included, as are a listing of alkaloids, plants containing alkaloids and some basic protocols of alkaloid analysis.* Presents the ecological role of alkaloids in nature and ecosystems * Interdisciplinary and reader friendly approach* Up-to-date knowledge
