Advances on the Gametocyte Biology, Host Immunity and Vector Stages to interrupt the Transmission of Malaria PDF Download
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Author: Linda Reiling
Publisher: Frontiers Media SA
ISBN: 2889763579
Category : Science
Languages : en
Pages : 126
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Book Description
Author: Linda Reiling
Publisher: Frontiers Media SA
ISBN: 2889763579
Category : Science
Languages : en
Pages : 126
Get Book Here
Book Description
Author: Rhoel Dinglasan
Publisher: Frontiers Media SA
ISBN: 2889664228
Category : Science
Languages : en
Pages : 158
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Book Description
The malaria parasite life cycle is complex and includes an obligatory developmental stage in its mosquito vector host. This transition from human-host to mosquito-host to human-host involves multiple developmental stages and divergent host tissues. Over the years, the research focus on the asexual stage parasites, which causes the symptoms of the disease, has transitioned towards a renewed focus on the transmission forms (or gametocytes), the only stages transmittable to the mosquito vector through ingestion of an infected blood meal. Analysis of sporozoite-liver interactions that result in the establishment of parasitic infection in the mammalian host has become an important research focus, and we now have a greater appreciation of the fascinating development of the sporozoites of the mosquito midgut wall and its travel to the salivary glands prior to inoculation into the mammalian dermis. This Research Topic embraces the full transition of the malaria parasite between its two obligatory hosts in what is termed as “malaria transmission biology”. Of note are the critical, enabling technologies and experimental systems that have been developed over the recent decade and have opened up significant new avenues for exploring the multi-stage, and multi-step processes that comprise malaria transmission biology. From uncovering that gametocyte development occurs in the bone marrow to quantifying the influence of both human host metabolism and parasite genetics on mosquito infection, it is clear that malaria transmission biology has entered an exciting era of discovery. Importantly, recent maturation of humanized liver mice and more sophisticated in vitro platforms have allowed more accurate recapitulations of the mosquito-to-skin-to-liver stages of human malaria infection. This allows both observation and study of the biological nuances of parasite vector-to-mammalian host transmission as well as interventions which can inhibit or block this stage of transmission. Paired with observations from clinical trials and the field, we can better understand exactly which parameters in which systems are most relevant for translation and biology.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 9780309045278
Category : Medical
Languages : en
Pages : 312
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Book Description
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Author: Dyann Fergus Wirth
Publisher:
ISBN: 9781621821229
Category : Medical
Languages : en
Pages : 0
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Book Description
Malaria is a mosquito-borne disease caused by parasitic protozoa that belong to the genus Plasmodium. This disease imposes a significant global health burden, claiming the lives of several thousand children and pregnant women each day. Increasing antimalarial drug resistance and the complexity of the Plasmodium life cycle, among other factors, have made eradication difficult. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biology, pathology, and epidemiology of malaria, as well as ongoing efforts to treat infections and manage their spread. Contributors discuss the Plasmodium life cycle, focusing on the molecular mechanisms by which the various parasitic stages induce clinical symptoms, interact with the immune system, and lead to further transmission of malaria. They also explore topics such as the interaction between mosquito reproduction and Plasmodium development, epigenetic regulation of malaria-associated genes, and unique features of malaria in pregnant women (e.g., parity-dependent susceptibility) and describe how an improved understanding of these phenomena may lead to novel intervention strategies. The driving forces behind antimalarial drug resistance are covered, as is progress in developing an effective vaccine and controlling mosquito populations. This volume is therefore an essential reference for all scientists, clinicians, and public health professionals interested in understanding malaria and reducing its devastating effects.
Author: Alfonso J. Rodriguez-Morales
Publisher:
ISBN: 9535127896
Category :
Languages : en
Pages : 508
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Book Description
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309165938
Category : Medical
Languages : en
Pages : 384
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Book Description
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Author:
Publisher: Springer
ISBN: 9781461483250
Category : Medical
Languages : en
Pages : 0
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Book Description
The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
Author: Sylvie Manguin
Publisher: BoD – Books on Demand
ISBN: 1789235502
Category : Medical
Languages : en
Pages : 454
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Book Description
Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.
Author: David P. Hughes
Publisher: Oxford University Press
ISBN: 0199642230
Category : Science
Languages : en
Pages : 247
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Book Description
Parasites that manipulate the behaviour of their hosts represent striking examples of adaptation by natural selection. This text provides an authoritative review of host manipulation by parasites that assesses developments in the field and lays out a framework for future research.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241565152
Category : Medical
Languages : en
Pages : 283
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Book Description
The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.
