Advances in the Involvement of Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma PDF Download
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Author: Jerome R. Lechien
Publisher: Frontiers Media SA
ISBN: 2889747557
Category : Medical
Languages : en
Pages : 160
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Book Description
Author: Jerome R. Lechien
Publisher: Frontiers Media SA
ISBN: 2889747557
Category : Medical
Languages : en
Pages : 160
Get Book Here
Book Description
Author: International Agency for Research on Cancer
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 180
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Book Description
This volume reviews the evidence for a causal link between sexually transmitted infection with human papillomavirus (HPV) and the occurrence of cervical cancer, from a variety of different angles. Epidemiological studies and clinical, pathological, and cytological aspects of HPV infection are reviewed. Modern methods for analyzing HPV-DNA types by molecular biological techniques are described, and the statistical problems to be overcome in epidemiological work are explained. The volume was prepared by a broad team of experts from around the world, who met in Copenhagen in March 1988 to reach a consensus on the present state of understanding and to establish directions for future work.
Author: Barbara Burtness
Publisher: Springer Science & Business Media
ISBN: 146148815X
Category : Medical
Languages : en
Pages : 360
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Book Description
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. In the past several years, there have been significant developments in understanding of HNC. It is now recognized that although alcohol and tobacco use has represented the likely predominant cause of SCCHN, the incidence of a second class of SCCHN related to oncogenic human papillomavirus (HPV) infection is increasing, with a four-fold increase in the past 2 decades, and now thought to represent up to 30% of cases. The first effective target for SCCHN, the EGFR-targeting antibody cetuximab, was approved as recently as in 2006; since then, a growing body of research has identified additional signaling pathways as important in disease pathogenesis, and in resistance to treatment. Proteins such as c-Met, Src, and HER2 are emerging as new therapeutic targets, with a considerable ferment in the clinical trial community. As a capstone of research progress, 2011 marked the first reports of high throughput sequencing of SCCHN tumors, with these efforts identifying unexpected players such as Notch as frequent subject of mutation, spawning new hypotheses for future research. This book will be of interest to researchers who are interested in better understanding the biology of head and neck cancers, with the goals of better designing therapies, identifying risk factors, or investigating the molecular basis of the disease.
Author: Jan B. Vermorken
Publisher: Springer Nature
ISBN: 3031231759
Category : Medical
Languages : en
Pages : 361
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Book Description
This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.
Author: Carole Fakhry
Publisher: Springer
ISBN: 8132224132
Category : Medical
Languages : en
Pages : 144
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Book Description
This book serves a snapshot of the current knowledge base in field. As human papillomavirus (HPV) causes a rising number of oropharyngeal cancers, understanding the biological, clinical and social implications of this infection has become increasingly important for head and neck practitioners. This book reflects the multidisciplinary nature of the scientific and clinical questions involved in this disease. Experts in epidemiology, diagnosis and treatment of HPV-related oropharyngeal cancer present in-depth reviews which will help to improve the reader’s understanding of this topic. The authors provide insight for answers of common patient and provider questions about HPV infection and related disease, and highlight remaining questions to be answered in the coming years.
Author: Daniel L. Miller
Publisher: Springer
ISBN: 3319211005
Category : Medical
Languages : en
Pages : 316
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Book Description
Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
Author:
Publisher: ScholarlyEditions
ISBN: 1481618490
Category : Medical
Languages : en
Pages : 45
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Book Description
Alphapapillomavirus—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Alphapapillomavirus in a concise format. The editors have built Alphapapillomavirus—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Alphapapillomavirus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alphapapillomavirus—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Wojciech Golusiński
Publisher: Springer
ISBN: 3319435809
Category : Medical
Languages : en
Pages : 257
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Book Description
This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.
Author: Gerd Gross
Publisher: Springer Science & Business Media
ISBN: 3642146635
Category : Medical
Languages : en
Pages : 896
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Book Description
This comprehensive, up-to-date reference book is intended to serve as the standard guide in the field. It covers the epidemiology and etiology of the various sexually transmitted infections and associated diseases, reviews novel diagnostic methods, and discusses in depth both new and established treatment methods. An important part of the book is devoted to prevention and particularly to immunoprevention by vaccination. Related issues such as sexual abuse, psychosocial aspects, and economic and political considerations are also included. The expertise of many worldwide renowned specialists and superb color illustrations make this book a valuable resource for practitioners from a variety of medical disciplines. It has a reader-friendly structure with “core messages” and “take-home pearls”.
Author: Rasha Abu-Eid
Publisher: Frontiers Media SA
ISBN: 2889458393
Category :
Languages : en
Pages : 64
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Book Description
Understanding the immunology of different cancers has led to great advances in developing cancer immunotherapies which are successfully used in generating effective anti-tumour immune responses. Head and neck cancers are no exception and various immunotherapies are now under study for the treatment of this diverse group of diseases. The articles in in this eBook provide a range of topics that highlight some of the latest advances in head and neck cancer immunology and immunotherapy. The authors of these articles provide their unique insight and expertise and suggest future directions for translational clinical research.
