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Author: Niall M. Adams
Publisher: Springer Science & Business Media
ISBN: 9048198992
Category : Medical
Languages : en
Pages : 214
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Book Description
This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
Author: Niall M. Adams
Publisher: Springer Science & Business Media
ISBN: 9048198992
Category : Medical
Languages : en
Pages : 214
Get Book Here
Book Description
This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
Author: Niall M. Adams
Publisher: Springer
ISBN: 9789048198986
Category : Medical
Languages : en
Pages : 210
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Book Description
This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
Author: Christophe Lavelle
Publisher: Academic Press
ISBN: 012803503X
Category : Medical
Languages : en
Pages : 618
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Book Description
Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds
Author: Jun Wang
Publisher: Elsevier
ISBN: 0323999468
Category : Science
Languages : en
Pages : 465
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Book Description
Nuclear Power Reactor Designs: From History to Advances analyzes nuclear designs throughout history and explains how each of those has helped to shape and inform the nuclear reactor designs of today and the future. Focused on the structure, systems and relevant components of each reactor design, this book provides the readers with answers to key questions to help them understand the benefits of each design. Each reactor design is introduced, their origin defined, and the relevant research presented before an analysis of its successes, what was learned, and how research and technology advanced as a result are presented. Students, researchers and early career engineers will gain a solid understanding of how nuclear designs have evolved, and how they will continue to develop in the future. Presents reactor designs through history to present day, focusing on key structures, systems and components Provides readers with quick answers about various design principles and rationales Includes new approaches such as the micro-reactor and small-modular reactors
Author: Lisa M. Pauli
Publisher:
ISBN:
Category :
Languages : en
Pages : 127
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Book Description
Since the inception of nuclear energy research, the element thorium (Th) has been considered the superior fuel for nuclear reactions because of its potency, safety, abundance and reduced waste. Cold War agendas broke from the logic of efficient energy production to establish a nationwide network of reactors designed to enrich uranium fuel for a nuclear arsenal. Contemporary dilemmas of global warming, increasing fuel prices, carbon emissions, and anti-proliferation movements have brought the discussion of clean, safe nuclear power to the forefront of American energy policy; it is no longer tolerable or sustainable to rely on a uranium (U) nuclear network. The architectural typology of nuclear energy has not been addressed in America for 35 years and is one that belies the promise of clean energy's progress through technology and public intervention. Containment Building is an architectural response to nuclear technological advancement that challenges historical separation between nuclear power and the public. It is a self-sustained, thorium-powered nuclear plant sited in and powering New York City. It is a nuclear campus that programatically and urbanistically engages the public and contains radio isotope labs, a nuclear medicine and imaging facility, a food irradiation center, a wellness hotel and spa, an electric taxi charging station, and a plug-in park along the Hudson River waterfront.
Author: Ernest J. Henley
Publisher: Elsevier
ISBN: 1483215660
Category : Technology & Engineering
Languages : en
Pages : 378
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Book Description
Advances in Nuclear Science and Technology, Volume 9 provides information pertinent to the fundamental aspects of nuclear science and technology. This book discusses the safe and beneficial development of land-based nuclear power plants. Organized into five chapters, this volume begins with an overview of the possible consequences of a large-scale release of radioactivity from a nuclear reactor in the event of a serious accident. This text then discusses the extension of conventional perturbation techniques to multidimensional systems and to high-order approximations of the Boltzmann equation. Other chapters consider details of probability treatment of the conventionally assumed loss-of-pressure accident to a modern gas-cooled reactor. This book discusses as well details of reliability analysis of a typical electromechanical protective system. The final chapter deals with the computer applications and the need for standardization as both computing and nuclear energy shifted from research and development to industry status. This book is a valuable resource for reactor physicists, engineers, scientists, and research workers.
Author: Paul Denis Stevenson
Publisher: Frontiers Media SA
ISBN: 2889665674
Category : Science
Languages : en
Pages : 171
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Book Description
Author: Pascal Yvon
Publisher: Woodhead Publishing
ISBN: 0081009127
Category : Technology & Engineering
Languages : en
Pages : 686
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Book Description
Operating at a high level of fuel efficiency, safety, proliferation-resistance, sustainability and cost, generation IV nuclear reactors promise enhanced features to an energy resource which is already seen as an outstanding source of reliable base load power. The performance and reliability of materials when subjected to the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors are essential areas of study, as key considerations for the successful development of generation IV reactors are suitable structural materials for both in-core and out-of-core applications. Structural Materials for Generation IV Nuclear Reactors explores the current state-of-the art in these areas. Part One reviews the materials, requirements and challenges in generation IV systems. Part Two presents the core materials with chapters on irradiation resistant austenitic steels, ODS/FM steels and refractory metals amongst others. Part Three looks at out-of-core materials. Structural Materials for Generation IV Nuclear Reactors is an essential reference text for professional scientists, engineers and postgraduate researchers involved in the development of generation IV nuclear reactors. Introduces the higher neutron doses and extremely corrosive higher temperature environments that will be found in generation IV nuclear reactors and implications for structural materials Contains chapters on the key core and out-of-core materials, from steels to advanced micro-laminates Written by an expert in that particular area
Author: Malgorzata Kloc
Publisher: Springer
ISBN: 9783031065750
Category : Science
Languages : en
Pages : 0
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Book Description
This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.
Author: Philippe Jeanteur
Publisher: Springer
ISBN: 3540742662
Category : Science
Languages : en
Pages : 153
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Book Description
This volume explores nuclear structure and trafficking involving or relevant to RNA and RNPs. Topics include advances and current problems in the structural organization of different subnuclear compartments, Cajal bodies and gems, speckles containing splicing factors, and PML bodies characteristic of ProMyelocytic leukemia. The book also describes the dynamic aspects of RNA trafficking and the latest technologies for live cell imaging of mRNA.