Advances in Genomic Sequence Analysis and Pattern Discovery

Advances in Genomic Sequence Analysis and Pattern Discovery PDF Author: Laura Elnitski
Publisher: World Scientific
ISBN: 9814327727
Category : Science
Languages : en
Pages : 236

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Book Description
Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

Advances in Genomic Sequence Analysis and Pattern Discovery

Advances in Genomic Sequence Analysis and Pattern Discovery PDF Author: Laura Elnitski
Publisher: World Scientific
ISBN: 9814327727
Category : Science
Languages : en
Pages : 236

Get Book Here

Book Description
Mapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.

Sequence — Evolution — Function

Sequence — Evolution — Function PDF Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482

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Book Description
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Modern Biocatalysis

Modern Biocatalysis PDF Author: Gavin Williams
Publisher: Royal Society of Chemistry
ISBN: 1788014537
Category : Science
Languages : en
Pages : 594

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Book Description
The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Applications of Cloud Computing

Applications of Cloud Computing PDF Author: Prerna Sharma
Publisher: CRC Press
ISBN: 100021446X
Category : Computers
Languages : en
Pages : 190

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Book Description
In the era of the Internet of Things and with the explosive worldwide growth of electronic data volume, and associated need of processing, analysis, and storage of such a humongous amount of data, it has now become mandatory to exploit the power of massively parallel architecture for fast computation. Cloud computing provides a cheap source of such a computing framework for a large volume of data for real-time applications. It is, therefore, not surprising to see that cloud computing has become a buzzword in the computing fraternity over the last decade. Applications of Cloud Computing: Approaches and Practices lays a good foundation for the core concepts and principles of cloud computing applications, walking the reader through the fundamental ideas with expert ease. The book progresses on the topics in a step-by-step manner. It reinforces theory with a full-fledged pedagogy designed to enhance students' understanding and offer them a practical insight into the applications of it. It is a valuable source of knowledge for researchers, engineers, practitioners, and graduate and doctoral students working in the field of cloud computing. It will also be useful for faculty members of graduate schools and universities.

Parallel Processing and Applied Mathematics, Part II

Parallel Processing and Applied Mathematics, Part II PDF Author: Roman Wyrzykowski
Publisher: Springer
ISBN: 3642315003
Category : Computers
Languages : en
Pages : 687

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Book Description
This two-volume-set (LNCS 7203 and 7204) constitutes the refereed proceedings of the 9th International Conference on Parallel Processing and Applied Mathematics, PPAM 2011, held in Torun, Poland, in September 2011. The 130 revised full papers presented in both volumes were carefully reviewed and selected from numerous submissions. The papers address issues such as parallel/distributed architectures and mobile computing; numerical algorithms and parallel numerics; parallel non-numerical algorithms; tools and environments for parallel/distributed/grid computing; applications of parallel/distributed computing; applied mathematics, neural networks and evolutionary computing; history of computing.

Biological Data Mining And Its Applications In Healthcare

Biological Data Mining And Its Applications In Healthcare PDF Author: Xiaoli Li
Publisher: World Scientific
ISBN: 9814551023
Category : Science
Languages : en
Pages : 437

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Book Description
Biologists are stepping up their efforts in understanding the biological processes that underlie disease pathways in the clinical contexts. This has resulted in a flood of biological and clinical data from genomic and protein sequences, DNA microarrays, protein interactions, biomedical images, to disease pathways and electronic health records. To exploit these data for discovering new knowledge that can be translated into clinical applications, there are fundamental data analysis difficulties that have to be overcome. Practical issues such as handling noisy and incomplete data, processing compute-intensive tasks, and integrating various data sources, are new challenges faced by biologists in the post-genome era. This book will cover the fundamentals of state-of-the-art data mining techniques which have been designed to handle such challenging data analysis problems, and demonstrate with real applications how biologists and clinical scientists can employ data mining to enable them to make meaningful observations and discoveries from a wide array of heterogeneous data from molecular biology to pharmaceutical and clinical domains.

Advanced Data Mining Technologies in Bioinformatics

Advanced Data Mining Technologies in Bioinformatics PDF Author: Hsu, Hui-Huang
Publisher: IGI Global
ISBN: 1591408652
Category : Computers
Languages : en
Pages : 342

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Book Description
"This book covers research topics of data mining on bioinformatics presenting the basics and problems of bioinformatics and applications of data mining technologies pertaining to the field"--Provided by publisher.

Biological Sequence Analysis

Biological Sequence Analysis PDF Author: Richard Durbin
Publisher: Cambridge University Press
ISBN: 113945739X
Category : Science
Languages : en
Pages : 372

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Book Description
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Review of the Department of Energy's Genomics: GTL Program

Review of the Department of Energy's Genomics: GTL Program PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180716
Category : Science
Languages : en
Pages : 102

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Book Description
The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.

Genome Analysis: Current Procedures and Applications

Genome Analysis: Current Procedures and Applications PDF Author: Maria S. Poptsova
Publisher: Caister Academic Press
ISBN: 9781912530205
Category : Computers
Languages : en
Pages : 398

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Book Description
In recent years there have been tremendous achievements made in DNA sequencing technologies and corresponding innovations in data analysis and bioinformatics that have revolutionized the field of genome analysis.In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data; whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data; motif finding in promoter regions, enhancer prediction and nucleosome sequence code discovery from ChiP-Seq data; identification of methylation patterns in cancer from MeDIP-seq data; transposon identification in NGS data; metagenomics and metatranscriptomics; NGS of viral communities; and causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology with the last three chapters devoted to computational methods of RNA structure prediction including context-free grammar applications.An essential book for everyone involved in sequence data analysis, next-generation sequencing, high-throughput sequencing, RNA structure prediction, bioinformatics and genome analysis.