Neural and Synaptic Defects in Autism Spectrum Disorders PDF Download
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Author: Hansen Wang
Publisher: Frontiers Media SA
ISBN: 2889196283
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 287
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Book Description
Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.
Author: Hansen Wang
Publisher: Frontiers Media SA
ISBN: 2889196283
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 287
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Book Description
Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.
Author: Edenilson Brandl
Publisher: Edenilson Brandl
ISBN:
Category : Psychology
Languages : en
Pages : 871
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Book Description
Tay-Sachs disease is a devastating genetic disorder that profoundly affects individuals, families, and communities. Characterized by the progressive degeneration of nerve cells, it often leads to severe physical and cognitive impairments, ultimately resulting in premature death. For those diagnosed with Tay-Sachs, as well as their loved ones, the emotional and psychological toll can be as challenging as the physical manifestations of the disease. This book aims to bridge the gap between medical understanding and psychological support, offering a comprehensive guide to utilizing Cognitive Behavioral Therapy (CBT) as a tool for managing the emotional and mental health challenges associated with Tay-Sachs disease. While advancements in genetics and medical science continue to expand our knowledge of this condition, it is equally essential to address the psychological aspects that arise throughout the genetic journey. In the chapters that follow, we will explore a range of topics, from the biological underpinnings of Tay-Sachs and its genetic implications to the various emotional struggles experienced by individuals and families. We will delve into the principles of CBT, providing practical tools and strategies to help those affected by Tay-Sachs navigate their emotional landscapes. By integrating concepts from behavioral genetics, personalized therapeutic approaches, and effective pain management techniques, this book seeks to offer a holistic view of the psychological support available to those living with this condition. I have drawn on my experience in psychology and my passion for supporting individuals facing chronic illness to craft this resource. My hope is that readers will find solace, guidance, and empowerment through these pages. It is my belief that while we cannot change the course of Tay-Sachs disease, we can certainly change how we respond to it—both in our minds and in our hearts. I invite you to embark on this journey with me, as we explore the intersection of psychology, genetics, and compassion. Together, let us foster resilience, enhance well-being, and illuminate a path of understanding for those impacted by Tay-Sachs disease.
Author: Paolo Sassone-Corsi
Publisher: Springer
ISBN: 3319270699
Category : Medical
Languages : en
Pages : 141
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Book Description
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Author: Casper René Gøtzsche
Publisher: Frontiers Media SA
ISBN: 2889718522
Category : Science
Languages : en
Pages : 188
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Book Description
Author: Daniela Tropea
Publisher: Frontiers Media SA
ISBN: 2832500722
Category : Science
Languages : en
Pages : 202
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Book Description
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309303133
Category : Medical
Languages : en
Pages : 470
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Book Description
For patients and their loved ones, no care decisions are more profound than those made near the end of life. Unfortunately, the experience of dying in the United States is often characterized by fragmented care, inadequate treatment of distressing symptoms, frequent transitions among care settings, and enormous care responsibilities for families. According to this report, the current health care system of rendering more intensive services than are necessary and desired by patients, and the lack of coordination among programs increases risks to patients and creates avoidable burdens on them and their families. Dying in America is a study of the current state of health care for persons of all ages who are nearing the end of life. Death is not a strictly medical event. Ideally, health care for those nearing the end of life harmonizes with social, psychological, and spiritual support. All people with advanced illnesses who may be approaching the end of life are entitled to access to high-quality, compassionate, evidence-based care, consistent with their wishes. Dying in America evaluates strategies to integrate care into a person- and family-centered, team-based framework, and makes recommendations to create a system that coordinates care and supports and respects the choices of patients and their families. The findings and recommendations of this report will address the needs of patients and their families and assist policy makers, clinicians and their educational and credentialing bodies, leaders of health care delivery and financing organizations, researchers, public and private funders, religious and community leaders, advocates of better care, journalists, and the public to provide the best care possible for people nearing the end of life.
Author: Randi Jenssen Hagerman
Publisher: Oxford University Press, USA
ISBN: 019993780X
Category : Medical
Languages : en
Pages : 401
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Book Description
This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have lead to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
Author: Kevin J. Mitchell
Publisher: John Wiley & Sons
ISBN: 1118524888
Category : Medical
Languages : en
Pages : 384
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Book Description
Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Author: Eric R. Kandel
Publisher: McGraw Hill Professional
ISBN: 1259642240
Category : Medical
Languages : en
Pages : 1698
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Book Description
The gold standard of neuroscience texts―updated with hundreds of brand-new images and fully revised content in every chapter Doody's Core Titles for 2023! For more than 40 years, Principles of Neural Science has helped readers understand the link between the human brain and behavior. As the renowned text has shown, all behavior is an expression of neural activity and the future of both clinical neurology and psychiatry is dependent on the progress of neural science. Fully updated, this sixth edition of the landmark reference reflects the latest research, clinical perspectives, and advances in the field. It offers an unparalleled perspective on the the current state and future of neural science. This new edition features: Unmatched coverage of how the nerves, brain, and mind function NEW chapters on: - The Computational Bases of Neural Circuits that Mediate Behavior - Brain-Machine Interfaces - Decision-Making and Consciousness NEW section on the neuroscientific principles underlying the disorders of the nervous system Expanded coverage of the different forms of human memory Highly detailed chapters on stroke, Parkinson’s disease, and multiple sclerosis 2,200 images, including 300 new color illustrations, diagrams, radiology studies, and PET scans Principles of Neural Science, Sixth Edition benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior. The text is divided into nine sections: Part I: Overall Perspective provides an overview of the broad themes of neural science, including the basic anatomical organization of the nervous system and the genetic bases of nervous system function and behavior. Part II: Cell and Molecular Biology of Cells of the Nervous System examines the basic properties of nerve cells, including the generation and conduction of propagated signaling. Part III: Synaptic Transmission focuses on the electrophysiological and molecular mechanism of synaptic transmission with chapters on neuronal excitability, neurotransmitters, and transmitter release. Part IV: Perception discusses the various aspects of sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system. Part V: Movement considers the neural mechanisms underlying movement and examines a new treatment that addresses how the basal ganglia regulate the selection of motor actions and instantiate reinforcement learning. Part VI: The Biology of Emotion, Motivation and Homeostasis examines the neural mechanisms by which subcortical areas mediate homeostatic control mechanisms, emotions, and motivation. Part VII: Development and the Emergence of Behavior looks at the nervous system from early embryonic differentiation to the formation and elimination of synapses. Part VIII: Learning, Memory, Language and Cognition expands on the previous section, examining the cellular mechanisms of implicit and explicit memory storage, as well as decision-making and consciousness. Part IX: explores the neural mechanisms underlying diseases and disorders of the nervous system, including autism spectrum disorder, epilepsy, schizophrenia, and anxiety.
Author: Sally J. Rogers
Publisher: Guilford Press
ISBN: 1606236326
Category : Psychology
Languages : en
Pages : 321
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Book Description
Supported by the principles of developmental psychology and applied behavior analysis, ESDM's intensive teaching interventions are delivered within play-based, relationship-focused routines. The manual provides structured, hands-on strategies for working with very young children in individual and group settings to promote development in such key domains as imitation; communication; social, cognitive, and motor skills; adaptive behavior; and play. --from publisher description
