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Author: T. W. Stone
Publisher: Taylor & Francis
ISBN: 9780748400638
Category : Acetylcholine
Languages : en
Pages : 272
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Book Description
Author: T. W. Stone
Publisher: Taylor & Francis
ISBN: 9780748400638
Category : Acetylcholine
Languages : en
Pages : 272
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Book Description
Author: Ezio Giacobini
Publisher: Springer Science & Business Media
ISBN: 1461581494
Category : Medical
Languages : en
Pages : 673
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Book Description
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Author: Chris Carter
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 346
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Book Description
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields of life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effects in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridine) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to lay a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain. Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts to group the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
Author: British Council
Publisher:
ISBN:
Category : Best books
Languages : en
Pages : 868
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Book Description
Includes no. 53a: British wartime books for young people.
Author: British Library. Document Supply Centre
Publisher:
ISBN:
Category : Congresses and conventions
Languages : en
Pages : 990
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Book Description
Author:
Publisher:
ISBN:
Category : Neurology
Languages : en
Pages : 1022
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Book Description
Author:
Publisher:
ISBN:
Category : Bibliography, National
Languages : en
Pages : 2954
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Book Description
Author: Rae R. Matsumoto
Publisher: Springer Science & Business Media
ISBN: 0387365141
Category : Medical
Languages : en
Pages : 416
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Book Description
This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 0521874912
Category : Medical
Languages : en
Pages : 729
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Book Description
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author: Arthur James Wells
Publisher:
ISBN:
Category : Bibliography, National
Languages : en
Pages : 1656
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Book Description
