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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309292492
Category : Medical
Languages : en
Pages : 107
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Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309292492
Category : Medical
Languages : en
Pages : 107
Get Book Here
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: Ian Goldin
Publisher: Oxford University Press
ISBN: 0198736258
Category : Business & Economics
Languages : en
Pages : 217
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Book Description
What is development -- How does development happen? -- Why are some countries rich and others poor? -- What can be done to accelerate development? -- The evolution of development aid -- Sustainable development -- Globalization and development -- The future of development.
Author: Jacqueline H. Beckley
Publisher: John Wiley & Sons
ISBN: 1119149304
Category : Technology & Engineering
Languages : en
Pages : 416
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Book Description
Written primarily for directors and managers of food design and development, food scientists, technologists, and product developers, this book explains all the necessary information in order to help meet the increasing demands for innovation in an industry that is providing fewer resources. This updated edition, by a group of seasoned food industry business professionals and academics, provides a real-world perspective of what is occurring in the food industry right now, offers strategic frameworks for problem solving and R&D strategies, and presents methods needed to accelerate and optimize new product development. Accelerating New Food Product Design and Development, Second Edition features five brand new chapters covering all the changes that have occurred within the last decade: A Flavor Supplier Perspective, An Ingredient Supplier Perspective, Applying Processes that Accelerate New Product Development, Looking at How the University Prepares Someone for a Career in Food, and Innovative Packaging and Its Impact on Accelerated Product Development. Offers new perspectives on what really goes on during the development process Includes updated chapters fully describing the changes that have occurred in the food industry, both from a developer’s point of view as well as the consumer requirements Features a completely rewritten chapter covering the importance of packaging which is enhanced through 3D printing All of this against the impact on speed to market Filled with unique viewpoints of the business from those who really know and a plethora of new information, Accelerating New Food Product Design and Development, Second Edition will be of great interest to all professionals engaged in new food product design and development.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309142318
Category : Medical
Languages : en
Pages : 101
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Book Description
Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.
Author: Nicole Forsgren, PhD
Publisher: IT Revolution
ISBN: 1942788355
Category : Business & Economics
Languages : en
Pages : 251
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Book Description
Winner of the Shingo Publication Award Accelerate your organization to win in the marketplace. How can we apply technology to drive business value? For years, we've been told that the performance of software delivery teams doesn't matter―that it can't provide a competitive advantage to our companies. Through four years of groundbreaking research to include data collected from the State of DevOps reports conducted with Puppet, Dr. Nicole Forsgren, Jez Humble, and Gene Kim set out to find a way to measure software delivery performance―and what drives it―using rigorous statistical methods. This book presents both the findings and the science behind that research, making the information accessible for readers to apply in their own organizations. Readers will discover how to measure the performance of their teams, and what capabilities they should invest in to drive higher performance. This book is ideal for management at every level.
Author: Marvin L. Patterson
Publisher: Van Nostrand Reinhold Company
ISBN:
Category : Business & Economics
Languages : en
Pages : 184
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Book Description
"The time for rehashing America's lost battles on the world market has passed." "Now it's time to address a critical component of the economic battle plan: the product development process that creates the products that satisfy customer needs. How quickly these weapons of economic war are developed, how competitive they are, how timely they are deployed, and how supportable they are will determine the failure or success of American business in the 1990s." "Here is the right book at the right time...a concise blueprint to transform product development from a collection of ad hoc activities into an integrated, smoothly operating process. Written by the Director of Corporate Engineering for Hewlett-Packard, one of the most successfully innovative companies in America today, Accelerating Innovation shows how successful, well-tested concepts from the manufacturing domain can be readily transformed into the needy world of new product innovation." "Filled with clear-sighted analysis and practical explanations, this book will help management unleash innovation and creativity in development processes to meet the urgent need for bringing new technology to customers faster and more effectively than the competition." "Discover how to cope with the limited life span of today's products...anticipate changing consumer needs and desires...close the gap between new technology and products that apply it...bring leading-edge products to market fast...eliminate profit-threatening gaps between the "death" of obsolete products and the introduction of new ones...and enjoy higher returns on investment." "Accelerating Innovation provides a results-oriented model for transferring to product development the strategies that are moving manufacturers from the old era to the new one. Numerous real-life examples give you powerful insights into the time-based factoring and total quality management principles used so successfully in manufacturing and shows how to implement them in the product development cycle. Key chapters address how to shorten the innovation cycle time, applying the principle that success springs from focusing on the right issues; manage organization change so that change goes where you want it to go - and quickly, transfer quality principles used on the assembly line to the process of developing raw information and adding value to it, reduce innovation time by implementing the cost of quality principle (cost as a function of when an error is detected), manage information flow and bottlenecks, minimize changeover time; and much, much more." "Does your organization really have a handle on new product development? Are goals, objectives, processes, metrics, and controls in place? Are you equipped to create new products rationally and systematically, while continuously reducing innovation cycle times?" "Accelerating Innovation presents new thinking that will help you answer these questions with a resounding "yes." In product development, doing business the same old way is a formula for disaster. The time to act is long before the livelihood of the product development function is ever threatened. And if a company is trying to catch up, then it has to improve faster than its toughest competition if it ever expects to win." "Finally, here is a guide that can give you the critical advantage you need for success in product development - success that is no longer a luxury, but a necessity for survival."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Author: Robert Barner
Publisher: John Wiley & Sons
ISBN: 0470937033
Category : Business & Economics
Languages : en
Pages : 165
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Book Description
An invaluable resource for HR professionals and executive coaches, this book focuses on how to reduce the time needed to prepare high-potential (HIPO) leaders for next-level positions. Providing the leading trends, tools, and techniques in the industry, the book demystifies the process of HIPO development. It includes a powerful five-step process for increasing leaders' readiness, as well as a complete set of tools for running workshops on developmental planning and coaching. This text also serves as a core text for the author's Executive Coaching Certificate Programs.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309158060
Category : Medical
Languages : en
Pages : 442
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Book Description
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Author: Kurian, Oommen C.
Publisher: Observer Research Foundation
ISBN: 9387407845
Category :
Languages : en
Pages : 24
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Book Description
Author: Steven Lee Garman
Publisher:
ISBN:
Category : Douglas fir
Languages : en
Pages : 64
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Book Description
The goal of this simulation study was to provide information for defining thinning regimes for young Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) stands in the Central Cascades Adaptive Management Area, located in west-central Oregon. Specifically, this study used the ZELIG. PNW (3.0) gap model to evaluate effects of experimental thinning treatments on the development of late-successional attributes and on extracted merchantable volume. Sixty-four thinning treatments were simulated for four rotation intervals (260, 180, 100, and 80 years) starting with a 40-year-old managed Douglas-fir stand. The amount of time for five late successional attributes to reach defined threshold levels, long-term developmental trends of these attributes, and amount of extracted merchantable volume were recorded for each treatment. Stand conditions of selected treatments were used in a subsequent harvest rotation in which 64 additional experimental thinning treatments were applied and evaluated. A total of 1,744 thinning treatments was evaluated in this study. Results of this study confirm previous recommendations for accelerating development of late-successional attributes in young managed stands. Additionally, results show the potential for a range of thinning treatments to attain late-successional conditions in about the same amount of time, but with different tradeoffs in terms of merchantable volume and long-term stand conditions. In general, heavy thinning of existing stands at ages 40 and 60 years promoted rapid development of large boles, vertical diversity, and tree-species diversity, but provided the least amount of extracted volume and required artificial creation of dead wood. Treatments that retained more than 40 percent of the original overstory and thinned to 99 trees per hectare at age 60 delayed attainment of late-successional conditions by 10 to 30 years but provided 12 to 20 percent more extracted volume, resulted in higher levels of most late-successional attributes at the end of a rotation, and required less artificial creation of dead wood. Treatments providing the fastest development of late-successional conditions in subsequent rotations varied with the amount of canopy cover retained at the end of the first rotation. For stands starting with ÃÃY30 percent canopy cover, delaying the first commercial thin for 40 years promoted the most rapid development of vertical structure and shadetolerant stems. Lower canopy-retention levels required heavy or light thins in subsequent entries, depending on the rotation interval, for rapid development of late-successional attributes.
