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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309165938
Category : Medical
Languages : en
Pages : 384
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Book Description
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309165938
Category : Medical
Languages : en
Pages : 384
Get Book Here
Book Description
For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Author: Karen M. Masterson
Publisher: Penguin
ISBN: 0698140133
Category : History
Languages : en
Pages : 494
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Book Description
A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.
Author: Nancy Leys Stepan
Publisher: Reaktion Books
ISBN: 186189967X
Category : Medical
Languages : en
Pages : 311
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Book Description
The dream of a world completely free of disease may seem utopian, but eradication—used in its modern sense to mean the reduction of the number of cases of a disease to zero by deliberate public health interventions—has been pursued repeatedly. Campaigns against yellow fever, malaria, and smallpox have been among the largest, most costly programs ever undertaken in international public health. But only one so far has been successful—that against smallpox. And yet in 2007 Bill and Melinda Gates surprised the world with the announcement that they were committing their foundation to eradicating malaria. Polio eradication is another of their priorities. Are such costly programs really justifiable? The first comprehensive account of the major disease-eradication campaigns from the early twentieth century right up to the present, Eradication places these ambitious goals in their broad historical and contemporary contexts. From the life and times of the American arch-eradicationist Dr. Fred Lowe Soper (1893-1977), who was at the center of many of the campaigns and controversies surrounding eradication in his lifetime, to debates between proponents of primary health care approaches to ill health versus the eradicationists, Nancy Leys Stepan’s narrative suggests that today these differing public health approaches may be complementary rather than in conflict. Enlightening for general readers and specialists alike, Eradication is an illuminating look at some of the most urgent problems of health and disease around the world.
Author: Emilio Pampana
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 622
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Book Description
Author: Henry M. Staines
Publisher: Springer Science & Business Media
ISBN: 3034604793
Category : Medical
Languages : en
Pages : 318
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Book Description
Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
Author: Margaret Humphreys
Publisher: JHU Press
ISBN: 0801866375
Category : History
Languages : en
Pages : 209
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Book Description
This is the story of a war against a disease that we can never win but must continue to fight. In Malaria: Poverty, Race, and Public Health in the United States, Margaret Humphreys presents the first book-length account of the parasitic, insect-borne disease that has infected millions and influenced settlement patterns, economic development, and the quality of life at every level of American society, especially in the south. Humphreys approaches malaria from three perspectives: the parasite's biological history, the medical response to it, and the patient's experience of the disease. It addresses numerous questions including how the parasite thrives and eventually becomes vulnerable, how professionals came to know about the parasite and learned how to fight them, and how people view the disease and came to the point where they could understand and support the struggle against it. In addition Malaria: Poverty, Race, and Public Health in the United States argues that malaria control was central to the evolution of local and federal intervention in public health, and demonstrates the complex interaction between poverty, race, and geography in determining the fate of malaria.
Author: Sonia Shah
Publisher: Macmillan + ORM
ISBN: 1429981172
Category : Medical
Languages : en
Pages : 319
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Book Description
This deep dive into humanity’s very long fight against malaria is “a vivid and compelling history with a message that’s entirely relevant today” (Elizabeth Kolbert, Pulitzer Prize–winning author of The Sixth Extinction). In a time when every emergent disease inspires waves of panic, why aren’t we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we’ve known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them? Philanthropists from Laura Bush to Bono to Bill Gates have contributed to the effort to find a cure for malaria—but there’s much more that can be done to minimize its deadly effects. In The Fever, journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we’ve invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria’s jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity. “Fascinating . . . an absorbing account of human ingenuity and progress, and of their heartbreaking limitations.” —Publishers Weekly “A thrilling detective story, spanning centuries, about our erratic pursuit of a villain still at large . . . rich in colorful detail.” —Malcolm Molyneux, Professor, Liverpool School of Tropical Medicine
Author: King K. Holmes
Publisher: World Bank Publications
ISBN: 1464805253
Category : Medical
Languages : en
Pages : 1027
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Book Description
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author: Frank M. Snowden
Publisher: Yale University Press
ISBN: 0300128436
Category : Medical
Languages : en
Pages : 304
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Book Description
At the outset of the twentieth century, malaria was Italy’s major public health problem. It was the cause of low productivity, poverty, and economic backwardness, while it also stunted literacy, limited political participation, and undermined the army. In this book Frank Snowden recounts how Italy became the world center for the development of malariology as a medical discipline and launched the first national campaign to eradicate the disease. Snowden traces the early advances, the setbacks of world wars and Fascist dictatorship, and the final victory against malaria after World War II. He shows how the medical and teaching professions helped educate people in their own self-defense and in the process expanded trade unionism, women’s consciousness, and civil liberties. He also discusses the antimalarial effort under Mussolini’s regime and reveals the shocking details of the German army’s intentional release of malaria among Italian civilians—the first and only known example of bioterror in twentieth-century Europe. Comprehensive and enlightening, this history offers important lessons for today’s global malaria emergency.
Author: Eric D. Carter
Publisher: University of Alabama Press
ISBN: 0817317600
Category : History
Languages : en
Pages : 303
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Book Description
Enemy in the Blood: Malaria, Environment, and Development in Argentina examines the dramatic yet mostly forgotten history of malaria control in northwest Argentina. Carter traces the evolution of malaria science and policy in Argentina from the disease’s emergence as a social problem in the 1890s to its effective eradication by 1950. Malaria-control proponents saw the campaign as part of a larger project of constructing a modern identity for Argentina. Insofar as development meant building a more productive, rational, and hygienic society, the perceptions of a culturally backwards and disease-ridden interior prevented Argentina from joining the ranks of “modern” nations. The path to eradication, however, was not easy due to complicated public health politics, inappropriate application of foreign malaria control strategies, and a habitual misreading of the distinctive ecology of malaria in the northwest, especially the unique characteristics of the local mosquito vector. Homegrown scientific expertise, a populist public health agenda, and an infusion of new technologies eventually brought a rapid end to malaria’s scourge, if not the cure for regional underdevelopment. Enemy in the Blood sheds light on the often neglected history of northwest Argentina’s interior, adds to critical perspectives on the history of development and public health in modern Latin America, and demonstrates the merits of integrative socialenvironmental research.
