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Author: Oriol Güell
Publisher: Springer
ISBN: 3319640003
Category : Technology & Engineering
Languages : en
Pages : 162
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Book Description
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.
Author: Oriol Güell
Publisher: Springer
ISBN: 3319640003
Category : Technology & Engineering
Languages : en
Pages : 162
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Book Description
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.
Author: Joseph Loscalzo
Publisher: Harvard University Press
ISBN: 0674436539
Category : Medical
Languages : en
Pages : 449
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Book Description
Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 278
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Book Description
La visió completa del metabolisme cel·lular, és a dir, tenint en compte totes les reaccions que el componen, permet descobrir nous mecanismes i respostes que són impossibles d'obtenir amb els mètodes reduccionistes tradicionals. L'estudi d'una xarxa metabòlica completa requereix eines que pertanyen a la Biologia de Sistemes i a la Ciència de les Xarxes Complexes. La present tesi mostra com la combinació de les eines que pertanyen a aquests dos camps es pot aplicar per a descobrir noves propietats de les xarxes metabòliques. D'aquesta manera, s'han estudiat les xarxes metabòliques de tres bacteris amb les següents eines: (1) algoritme de cascada, que es pot usar per estudiar si les xarxes metabòliques poden sobreviure a inactivacions de determinades reaccions, (2) Flux Balance Analysis, que s'usa per a calcular els fluxos a través de les reaccions que composen la xarxa metabòlica suposant que l'objectiu biològic de l'organisme a estudiar és maximitzar la velocitat de creixement, (3) Disparity Filter, que permet obtenir versions reduïdes de xarxes metabòliques, cosa que facilita el seu estudi i anàlisi, i (4) Hit-And-Run, que permet obtenir totes les solucions metabòliques independentment de que maximitzin el creixement de l'organisme. En aquesta tesi es demostra que el metabolisme de les cèl·lules dels organismes vius ha evolucionat de forma que aconsegueix sobreviure a les inactivacions de les reaccions que el componen. Addicionalment, s'identifiquen les rutes metabòliques responsables dels processos evolutius i adaptatius que es donen en les xarxes metabòliques. A més, també es demostra que la tècnica Flux Balance Analysis dóna una solució de fluxos que no es representativa de totes les possibles solucions. Cal remarcar que això no invalida la tècnica, sinó que les assumpcions que usa donen una solució concreta que té sentit biològic però que és molt diferent de la resta de solucions. És important recalcar que els resultats obtinguts en aquesta tesi podrien emprar-se en aplicacions mèdiques, per exemple estudiar el metabolisme de les cèl·lules cancerígenes, que podia utilitzar-se per a que aquestes cèl·lules no proliferin en el cos dels humans, un fet que causa moltes problemes en l'ésser humà.
Author: Emily G. Armitage
Publisher: Springer
ISBN: 1493906151
Category : Science
Languages : en
Pages : 67
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Book Description
With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.
Author: Juan I. Castrillo
Publisher: Humana Press
ISBN: 9781617791727
Category : Science
Languages : en
Pages : 0
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Book Description
Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular BiologyTM series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all ‘omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.
Author: Mark Buchanan
Publisher: Cambridge University Press
ISBN: 0521882737
Category : Science
Languages : en
Pages : 282
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Book Description
Key introductory text for graduate students and researchers in physics, biology and biochemistry.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Category : Science
Languages : en
Pages : 570
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Book Description
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Anne Le
Publisher: Springer
ISBN: 331977736X
Category : Medical
Languages : en
Pages : 186
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Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author: Andres Kriete
Publisher: Academic Press
ISBN: 0124059384
Category : Computers
Languages : en
Pages : 549
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Book Description
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.