A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy PDF Download
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Author: Sánchez Arciniegas, Jorge Patricio
Publisher: KIT Scientific Publishing
ISBN: 3731511703
Category : Medical
Languages : en
Pages : 162
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Book Description
The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Author: Sánchez Arciniegas, Jorge Patricio
Publisher: KIT Scientific Publishing
ISBN: 3731511703
Category : Medical
Languages : en
Pages : 162
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Book Description
The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Author: Nagel, Claudia
Publisher: KIT Scientific Publishing
ISBN: 3731512815
Category :
Languages : en
Pages : 280
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Book Description
An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.
Author: Kevin A. Michael
Publisher:
ISBN: 9789535146230
Category : Cardiovascular system
Languages : en
Pages : 0
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Book Description
Author: David J. Christini
Publisher:
ISBN: 9780750320641
Category : Electrocardiography
Languages : en
Pages : 0
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Book Description
This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.
Author: Maria S. Guillem
Publisher: Frontiers Media SA
ISBN: 2889636712
Category :
Languages : en
Pages : 178
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Book Description
Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation
Author: Onkar N. Tripathi
Publisher: Springer Science & Business Media
ISBN: 3642175759
Category : Science
Languages : en
Pages : 676
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Book Description
Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
Author: Peter Kohl
Publisher: Oxford University Press
ISBN: 0199570167
Category : Medical
Languages : en
Pages : 508
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Book Description
Rev. ed. of: Cardiac mechano-electric feedback and arrhythmias. 2005.
Author: Luca Formaggia
Publisher: Springer Science & Business Media
ISBN: 8847011523
Category : Mathematics
Languages : en
Pages : 528
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Book Description
Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.
Author: Spyretta Golemati
Publisher: Springer
ISBN: 9811050929
Category : Technology & Engineering
Languages : en
Pages : 354
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Book Description
This book provides a comprehensive guide to the state-of-the-art in cardiovascular computing and highlights novel directions and challenges in this constantly evolving multidisciplinary field. The topics covered span a wide range of methods and clinical applications of cardiovascular computing, including advanced technologies for the acquisition and analysis of signals and images, cardiovascular informatics, and mathematical and computational modeling.
Author: J. Middleton
Publisher: CRC Press
ISBN: 9782919875009
Category : Medical
Languages : en
Pages : 582
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Book Description
These papers are concerned with new advances and novel solutions in the areas of biofluids, image-guided surgery, tissue engineering and cardovascular mechanics, implant analysis, soft tissue mechanics, bone remodeling and motion analysis. The contents also feature a special section on dental materials, dental adhesives and orthodontic mechanics. This edition contains many examples, tables and figures, and together with the many references, provides the reader with invaluable information on the latest theoretical developments and applications.
