Author: Sheila J. Ogden
Publisher: Elsevier Health Sciences
ISBN: 0323393667
Category : Medical
Languages : en
Pages : 627
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Book Description
Known for its textbook/workbook format, Calculation of Drug Dosages, 10th Edition makes it easy to master the ratio and proportion, formula, and dimensional analysis methods for drug calculation. A basic review of mathematics refreshes your math skills, and plenty of practice problems help you overcome any inexperience or weaknesses you may have. Written by nursing experts Sheila Ogden and Linda Fluharty, this resource helps you calculate drug dosages accurately and with confidence. An extensive math review covers the basic math skills essential for accurate calculation of drug dosages and helps you identify your strengths and weaknesses. Over 1,800 practice problems reinforce your understanding of drug calculations. A logical structure is organized from simple to complex, making it easier to absorb and retain knowledge. Learning objectives keep you focused and explain what you should accomplish upon completion of each chapter. An Alert box highlights information crucial to math calculation and patient safety. Chapter worksheets allow you to practice solving realistic problems. Post-tests at the end of each chapter let you assess your understanding of content. A comprehensive post-test at the end of the book offers additional practice and accurately gauges your overall understanding. Over 600 practice problems on the Evolve companion website cover ratio-proportion, formula, and dimensional analysis methods. 25 flash cards on Evolve contain abbreviations, formulas, and conversions from the book, allowing you to study at your own pace. UPDATED drug labels and equipment photos show the latest drugs and technology used in the market. NEW! Additional Intake and Output problems are included, and the apothecary method is minimized and moved to the appendix. NEW! Easy-access answer key is placed at the end of each chapter rather than in the back of the book.
Author: Mohith Agadi
Publisher: Mohith Agadi
ISBN: 1370055242
Category : Young Adult Nonfiction
Languages : en
Pages : 15
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Book Description
Authored by Mohith Agadi, A Dose of Space is a space knowledge material based on research findings and mission news from various space research organizations such as National Aeronautics and Space Administration (NASA), The Indian Space Research Organisation (ISRO), and others.
Author:
Publisher:
ISBN:
Category : Nuclear energy
Languages : en
Pages : 1256
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Book Description
Author: John O'Quigley
Publisher: CRC Press
ISBN: 149874611X
Category : Mathematics
Languages : en
Pages : 306
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Book Description
Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy, combination treatments and complex group structures has provided the stimulus to these advances. Typically, we deal with very small samples, sequential methods that need to be efficient, while, at the same time adhering to ethical principles due to the involvement of human subjects. Statistical inference is difficult since the standard techniques of maximum likelihood do not usually apply as a result of model misspecification and parameter estimates lying on the boundary of the parameter space. Bayesian methods play an important part in overcoming these difficulties, but nonetheless, require special consideration in this particular context. The purpose of this handbook is to provide an expanded summary of the field as it stands and also, through discussion, provide insights into the thinking of leaders in the field as to the potential developments of the years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis for more established researchers from which to build A collection of material for an advanced course in early phase clinical trials A comprehensive guide to available methodology for practicing statisticians on the design and analysis of dose-finding experiments An extensive guide for the multiple comparison and modeling (MCP-Mod) dose-finding approach, adaptive two-stage designs for dose finding, as well as dose–time–response models and multiple testing in the context of confirmatory dose-finding studies. John O’Quigley is a professor of mathematics and research director at the French National Institute for Health and Medical Research based at the Faculty of Mathematics, University Pierre and Marie Curie in Paris, France. He is author of Proportional Hazards Regression and has published extensively in the field of dose finding. Alexia Iasonos is an associate attending biostatistician at the Memorial Sloan Kettering Cancer Center in New York. She has over one hundred publications in the leading statistical and clinical journals on the methodology and design of early phase clinical trials. Dr. Iasonos has wide experience in the actual implementation of model based early phase trials and has given courses in scientific meetings internationally. Björn Bornkamp is a statistical methodologist at Novartis in Basel, Switzerland, researching and implementing dose-finding designs in Phase II clinical trials. He is one of the co-developers of the MCP-Mod methodology for dose finding and main author of the DoseFinding R package. He has published numerous papers on dose finding, nonlinear models and Bayesian statistics, and in 2013 won the Royal Statistical Society award for statistical excellence in the pharmaceutical industry.
Author: Guosheng Yin
Publisher: John Wiley & Sons
ISBN: 0470581719
Category : Medical
Languages : en
Pages : 368
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Book Description
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author: L.I. Miroshnichenko
Publisher: Springer Science & Business Media
ISBN: 9401703019
Category : Science
Languages : en
Pages : 254
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Book Description
The mono graph contains 8 chapters, and their contents cover all principal aspects of the problem: 1. Introduction and brief his tory ofthe radiation problem and background information ofradiation hazard in the near-Earth and interplanetary space. 2. General description of radiation conditions and main sources of charged partic1es in the Earth's environment and interplanetary space, effects of space environment on spacecraft. 3. Basic information about physical conditions in space and main sources of charged particles in the Earth's environment and interplanetary space, in the context of "Space W eather" monitoring and prediction. 4. Trapped radiation belts of the Earth (ERB): theory of their origin, spatial and temporal dynamics, and experimental and statistical models. 5. Galactic cosmic rays (GCR): variations of energetic, temporal and spatial characteristics, long-term modulation, and anomalous cosmic ray (ACR) component, modeling oftheir dynamics. 6. Production of energetic particles (SEPs) at/ne ar the Sun: available databases, acceleration, propagation, and prediction of individual SEP event, statistical models of solar cosmic rays (SCR). 7. Existing empirical techniques of estimating, prediction and modeling of radiation hazard, methodical approaches and constraints, some questions of changes in the Earth's radiation environment due to changes of the solar activity level. 8. Unresolved problems of radiation hazard prediction and spacecraft protection, radiation experiments on board the spacecraft, estimating of radiation conditions during interplanetary missions. Space does not allow us to explain every time the solar-terrestrial and radiation physics nomencIature used in current English-language literature.
Author:
Publisher:
ISBN:
Category : Aeronautics
Languages : en
Pages : 1028
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Book Description
Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
Author: Arthur Reetz
Publisher:
ISBN:
Category : Shielding (Radiation)
Languages : en
Pages : 576
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Book Description
Author: Henry Dwight Chapin
Publisher:
ISBN:
Category :
Languages : en
Pages : 692
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Book Description
Author: Royal Society of Edinburgh
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 934
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Book Description
