A [2+2] Photocycloaddition-Fragmentation Approach for Cis-Fused Lycorine-type Natural Product Synthesis PDF Download
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Author: Maike H. Wahl
Publisher:
ISBN: 9783843939737
Category :
Languages : en
Pages :
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![A [2+2] Photocycloaddition-Fragmentation Approach for Cis-Fused Lycorine-type Natural Product Synthesis PDF](https://books.google.com/books/content/images/frontcover/YUfmxQEACAAJ?fife=w80-h100)
Author: Maike H. Wahl
Publisher:
ISBN: 9783843939737
Category :
Languages : en
Pages :
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![Toward a Visible Light Mediated [2+2] Photocycloaddition-cyclobutane Fragmentation Synthesis of Natural Products PDF](https://books.google.com/books/content/images/frontcover/DMKdzgEACAAJ?fife=w80-h100)
Author: Jeffrey Rein
Publisher:
ISBN:
Category : Antifungal agents
Languages : en
Pages : 246
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Author: Roel Klein Nijenhuis
Publisher:
ISBN: 9789462954953
Category :
Languages : en
Pages : 229
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Book Description
[2+2]-Photocycloaddition is a powerful method to synthesise highly strained, complex and multicyclic compounds. The research described in this thesis focusses on using this reaction to pursue the total synthesis of a number of complex natural products. The main project focusses on the synthesis of solanoeclepin A, an extremely potent hatching agent of the potato cyst nematode. To reach this goal, the molecule was divided in two parts, the left- and the right-hand substructure. With the left-hand substructure completed in previous research, the goal was now to synthesise the right-hand substructure, and to complete the total synthesis by connecting the two fragments. The key step is a [2+2]-photocycloaddition of 2-substituted 3-methyl-2-cyclohexenones, described in chapter 3. Using this reaction the highly strained bicyclo[2.1.1]cyclohexane core structure of the natural product was accessed from simple starting materials in a few steps. A racemic approach to the right-hand substructure of solanoeclepin A is described in chapter 2. Extensive research ultimately led to a short and efficient enantioselective formal synthesis of solanoeclepin A, as described in chapter 4. Finally, the efforts to combine both fragments are described in chapter 5. The final chapter describes the first total syntheses of aquatolide and wilfolide B. Aquatolide was prepared using the [2+2]-photocycloaddition of an allene-substituted pentenolide, ultimately leading to the natural product. Retro-ene type rearrangement of the cycloaddition product led to a different carbon skeleton, leading to the successful total synthesis of wilfolide B.
Author: E.J. Corey
Publisher: Рипол Классик
ISBN: 5885010811
Category : Science
Languages : en
Pages : 447
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Author: Corey R.J. Stephenson
Publisher: John Wiley & Sons
ISBN: 3527335609
Category : Science
Languages : en
Pages : 454
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Book Description
Filling the need for a ready reference that reflects the vast developments in this field, this book presents everything from fundamentals, applications, various reaction types, and technical applications. Edited by rising stars in the scientific community, the text focuses solely on visible light photocatalysis in the context of organic chemistry. This primarily entails photoinduced electron transfer and energy transfer chemistry sensitized by polypyridyl complexes, yet also includes the use of organic dyes and heterogeneous catalysts. A valuable resource to the synthetic organic community, polymer and medicinal chemists, as well as industry professionals.
Author: Michael Harmata
Publisher: Elsevier
ISBN: 0080546390
Category : Science
Languages : en
Pages : 260
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Book Description
This volume presents work from six different groups working on various aspects of cycloaddition chemistry. José Mascareñas gives us a very interesting account of the chemistry of &Bgr;-alkoxy-&ggr;-pyrones and related species. Al Padwa and Chris Staub discuss further advances in rhodium carbenoid chemistry and the unusual cycloaddition processes possible with these intermediates. Higher order cycloadditions mediated by transition metals highlight Jim Rigby's update on his group's efforts in this area. Lily Lee and John Snyder present us with a detailed account of the indole ring as a dienophile, challenging us to consider the untapped potential in this area. Brian Keay and Ian Hunt discuss the intramolecular Diels-Alder reactions of furan; a report that is both top-notch science, and what could be a great learning tool for students who need to see how fundamental chemical principles can and should be applied to synthetic problems. Finally, Kay Brummond introduces us to a new version of the Pauson-Khand reactions, one that will no doubt be further exploited in productive ways by her group well into the future.
Author: V. Ramamurthy
Publisher: John Wiley & Sons
ISBN: 1118095294
Category : Science
Languages : en
Pages : 511
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Book Description
This is the most updated, comprehensive collection of monographs on all aspects of photochemistry and photophysics related to natural and synthetic, inorganic, organic, and biological supramolecular systems. Supramolecular Photochemistry: Controlling Photochemical Processes addresses reactions in crystals, organized assemblies, monolayers, zeolites, clays, silica, micelles, polymers, dendrimers, organic hosts, supramolecular structures, organic glass, proteins and DNA, and applications of photosystems in confined media. This landmark publication describes the past, present, and future of this growing interdisciplinary area.
Author: Douglass F. Taber
Publisher: Oxford University Press
ISBN: 0190646160
Category : Science
Languages : en
Pages : 289
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Book Description
A collection of Douglass Taber's columns originally published between 2013 - 2015 at www.organicchemistry.org
Author: Ali S. Faqi
Publisher: Academic Press
ISBN: 0123878160
Category : Medical
Languages : en
Pages : 903
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Book Description
A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. - Chapters written by world-renowned contributors who are experts in their fields - Includes the latest research in preclinical drug testing and international guidelines - Covers preclinical toxicology in small molecules and biologics in one single source
Author: Carmen Claver
Publisher: Springer
ISBN: 3319666657
Category : Science
Languages : en
Pages : 291
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Book Description
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.
