Author: Stephanie Tumidajski
Publisher:
ISBN:
Category :
Languages : en
Pages : 372
Book Description
Iminoacetonitriles participate as activated imino dienophiles in intermolecular and intramolecular aza Diels-Alder reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are versatile synthetic intermediates that participate in a variety of stereoselective transformations to further elaborate the six-membered ring. This thesis describes the scope of the intermolecular [4 + 2] cycloaddition of N-benzyliminoacetonitrile with unactivated and activated dienes, as well as, the synthetic elaboration of the cycloadducts. This thesis also describes the worked performed to complete the total syntheses of indolizidines (-)- 235B', (-)-235B", and (+)-235B" using the aza Diels-Alder reaction of an iminoacetonitrile as the key step.
4 + 2 Cycloadditions of Iminoacetonitriles
Author: Stephanie Tumidajski
Publisher:
ISBN:
Category :
Languages : en
Pages : 372
Book Description
Iminoacetonitriles participate as activated imino dienophiles in intermolecular and intramolecular aza Diels-Alder reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are versatile synthetic intermediates that participate in a variety of stereoselective transformations to further elaborate the six-membered ring. This thesis describes the scope of the intermolecular [4 + 2] cycloaddition of N-benzyliminoacetonitrile with unactivated and activated dienes, as well as, the synthetic elaboration of the cycloadducts. This thesis also describes the worked performed to complete the total syntheses of indolizidines (-)- 235B', (-)-235B", and (+)-235B" using the aza Diels-Alder reaction of an iminoacetonitrile as the key step.
Publisher:
ISBN:
Category :
Languages : en
Pages : 372
Book Description
Iminoacetonitriles participate as activated imino dienophiles in intermolecular and intramolecular aza Diels-Alder reactions affording tetrahydropyridines and indolizidines. The [alpha]-amino nitrile cycloadducts are versatile synthetic intermediates that participate in a variety of stereoselective transformations to further elaborate the six-membered ring. This thesis describes the scope of the intermolecular [4 + 2] cycloaddition of N-benzyliminoacetonitrile with unactivated and activated dienes, as well as, the synthetic elaboration of the cycloadducts. This thesis also describes the worked performed to complete the total syntheses of indolizidines (-)- 235B', (-)-235B", and (+)-235B" using the aza Diels-Alder reaction of an iminoacetonitrile as the key step.
Enantioselective [4 + 2] Cycloadditions of Iminoacetonitriles
Author: Shaun David Fontaine
Publisher:
ISBN:
Category :
Languages : en
Pages : 331
Book Description
Iminoacetonitriles participate as reactive dienophiles in intramolecular Diels-Alder cycloadditions affording quinolizidines and indolizidines. The resulting a-amino nitrile cycloadducts are versatile intermediates that can be further elaborated in a stereoselective manner. This thesis describes the development of intramolecular, enantioselective aza Diels- Alder cycloadditions promoted by chiral Brønsted acids as well as the discovery that iminoacetonitriles can also participate in acid catalyzed cycloadditions. The second part of this thesis reports the total synthesis of (-)-quinolizidine 2071 using an intramolecular, enantioselective cycloaddition of an iminoacetonitrile as the key step.
Publisher:
ISBN:
Category :
Languages : en
Pages : 331
Book Description
Iminoacetonitriles participate as reactive dienophiles in intramolecular Diels-Alder cycloadditions affording quinolizidines and indolizidines. The resulting a-amino nitrile cycloadducts are versatile intermediates that can be further elaborated in a stereoselective manner. This thesis describes the development of intramolecular, enantioselective aza Diels- Alder cycloadditions promoted by chiral Brønsted acids as well as the discovery that iminoacetonitriles can also participate in acid catalyzed cycloadditions. The second part of this thesis reports the total synthesis of (-)-quinolizidine 2071 using an intramolecular, enantioselective cycloaddition of an iminoacetonitrile as the key step.
4+2 Cycloadditions of Iminoacetonitriles
Author: Kevin Matthew Maloney
Publisher:
ISBN:
Category :
Languages : en
Pages : 532
Book Description
Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthesis of iminoacetonitriles, the scope of their Diels-Alder reactions, and the synthetic elaboration of the a-amino nitrile cycloadducts to provide access to a variety of substituted quinolizidine and indolizidine derivatives. The second part of this thesis reports on the total synthesis of quinolizidine ( - )-217A and our efforts directed toward the total synthesis of indolizidine ( - )-235B'.
Publisher:
ISBN:
Category :
Languages : en
Pages : 532
Book Description
Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthesis of iminoacetonitriles, the scope of their Diels-Alder reactions, and the synthetic elaboration of the a-amino nitrile cycloadducts to provide access to a variety of substituted quinolizidine and indolizidine derivatives. The second part of this thesis reports on the total synthesis of quinolizidine ( - )-217A and our efforts directed toward the total synthesis of indolizidine ( - )-235B'.
Synthesis of Nitrogen Heterocycles Via the Intramolecular [4+2] Cycloaddition of Iminoacetonitriles
Author: David Thomas Amos
Publisher:
ISBN:
Category :
Languages : en
Pages : 367
Book Description
Iminoacetonitriles have been shown to function as aza dienophiles in intramolecular Diels-Alder reactions, affording substituted quinolizidines and indolizidines. The cycloadducts are formed with a high preference for an exo-orientated cyano group due to the a-amino nitrile anomeric effect. The substrates for these [4+2] cycloadditions are prepared from readily available alcohols via a Mitsunobu reaction with the previously unknown N-cyanomethyltriflamide (HN(Tf)CH2CN) followed by cesium carbonate promoted elimination of trifluoromethanesulfinate. The a-amino nitrile cycloadducts are versatile synthetic intermediates and can be elaborated via alkylation, reduction, and nucleophilic addition chemistry to provide a variety of substituted and functionalized nitrogen heterocycles. Initial investigations have been undertaken to explore the use of this methodology in the total synthesis of alkaloid natural products.
Publisher:
ISBN:
Category :
Languages : en
Pages : 367
Book Description
Iminoacetonitriles have been shown to function as aza dienophiles in intramolecular Diels-Alder reactions, affording substituted quinolizidines and indolizidines. The cycloadducts are formed with a high preference for an exo-orientated cyano group due to the a-amino nitrile anomeric effect. The substrates for these [4+2] cycloadditions are prepared from readily available alcohols via a Mitsunobu reaction with the previously unknown N-cyanomethyltriflamide (HN(Tf)CH2CN) followed by cesium carbonate promoted elimination of trifluoromethanesulfinate. The a-amino nitrile cycloadducts are versatile synthetic intermediates and can be elaborated via alkylation, reduction, and nucleophilic addition chemistry to provide a variety of substituted and functionalized nitrogen heterocycles. Initial investigations have been undertaken to explore the use of this methodology in the total synthesis of alkaloid natural products.
Organic Reaction Mechanisms 2003
Author: A. C. Knipe
Publisher: John Wiley & Sons
ISBN: 0470061235
Category : Science
Languages : en
Pages : 644
Book Description
The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 2003 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 2003. The 39th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Publisher: John Wiley & Sons
ISBN: 0470061235
Category : Science
Languages : en
Pages : 644
Book Description
The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 2003 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 2003. The 39th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Index Medicus
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1902
Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1902
Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Directory of Graduate Research
Author: American Chemical Society. Committee on Professional Training
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 1932
Book Description
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 1932
Book Description
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Dissertation Abstracts International
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 980
Book Description
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 980
Book Description
Organic Reaction Mechanisms 2004
Author: A. C. Knipe
Publisher: Wiley
ISBN: 9780470018477
Category : Science
Languages : en
Pages : 720
Book Description
The 40th annual volume in this highly successful and unique series surveying the advances in the understanding of organic reaction mechanisms. In every volume the content is divided in the different classes of organic reaction mechanisms, including: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Elimination Reactions Radical Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. As a new service to the reader all reaction mechanisms leading to stereospecific products are highlighted. This reflects the needs of the organic synthetic community with leads to chiral reactions.
Publisher: Wiley
ISBN: 9780470018477
Category : Science
Languages : en
Pages : 720
Book Description
The 40th annual volume in this highly successful and unique series surveying the advances in the understanding of organic reaction mechanisms. In every volume the content is divided in the different classes of organic reaction mechanisms, including: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Elimination Reactions Radical Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. As a new service to the reader all reaction mechanisms leading to stereospecific products are highlighted. This reflects the needs of the organic synthetic community with leads to chiral reactions.
Journal
Author: American Chemical Society
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 990
Book Description
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 990
Book Description