Role of CD1- and MR1-restricted T cells in Immunity and Disease PDF Download
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Author: Kazuya Iwabuchi
Publisher: Frontiers Media SA
ISBN: 2889631222
Category :
Languages : en
Pages : 429
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Book Description
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Author: Kazuya Iwabuchi
Publisher: Frontiers Media SA
ISBN: 2889631222
Category :
Languages : en
Pages : 429
Get Book
Book Description
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Author: Freddy Radtke
Publisher: Springer Science & Business Media
ISBN: 3642242936
Category : Medical
Languages : en
Pages : 192
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Book Description
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
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ISBN:
Category :
Languages : en
Pages : 544
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Book Description
Author: William Boughton King
Publisher:
ISBN:
Category : Coal gasification
Languages : en
Pages : 552
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Book Description
Author: H. Simon Schaaf
Publisher: Elsevier Health Sciences
ISBN: 1437711065
Category : Medical
Languages : en
Pages : 1049
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Book Description
This book provides all the vital information you need to know about tuberculosis, especially in the face of drug-resistant strains of the disease. Coverage includes which patient populations face an elevated risk of infection, as well as which therapies are appropriate and how to correctly monitor ongoing treatment so that patients are cured. Properly administer screening tests, interpret their results, and identify manifestations of the disease, with authoritative guidance from expert clinicians from around the world. Discusses screening tests for tuberculosis so you can interpret their results and identify not only common manifestations of the disease, but also those that are comparatively rare—such as tuberculosis in pregnant women. Covers all clinical aspects of tuberculosis in children, including current practices on managing those infected with HIV. Provides details on how best to interact with the public health system in both industrialized and developing countries. Addresses the social aspects of tuberculosis and presents the latest advances on new and potential vaccines against tuberculosis. Offers the expertise of internationally recognized tuberculosis clinicians to provide you with well-rounded, global coverage. Features numerous illustrations to provide clear and detailed depictions of rare manifestations of tuberculosis.
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ISBN:
Category : Physics
Languages : en
Pages : 1024
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Book Description
Section A includes general physics, solid state physics, applied physics.
Author: Ian R. Tizard
Publisher: Elsevier Health Sciences
ISBN: 032352348X
Category : Medical
Languages : en
Pages : 552
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Book Description
Exploring the immunologic concerns of both large and small animals, Veterinary Immunology: An Introduction,10th Edition is the only complete resource on immunology for veterinary practitioners. This new edition has been meticulously updated to continue its trend of incorporating the latest advances and topics in the field. It features a straightforward presentation of basic immunologic principles along with thorough and timely information on the most significant immunologic diseases and responses seen in domestic animals. Comprehensive coverage clearly explains the general principles of immunology, and provides information on the most significant immunologic diseases and immunologic responses seen in domestic animals and marine mammals. A wealth of clinical examples show how principles will be experienced and addressed in the clinical setting. Educator and student resources on Evolve feature an image collection, enhanced animations, flashcards, content updates, and a test bank for instructors. Improved images clarify new content and enhance your understanding. NEW! Updated content covers new T cell subpopulations, newly described interleukins; new approaches to cancer immunotherapy; immunology of fish; and new advances in genomics. NEW! Learning objectives have been added to the beginning of each chapter. NEW! Chapter on commensal bacterial will address the role of commensal bacteria in veterinary immunology and provide convincing explanations for previously poorly understood phenomena. NEW! Information on the pathogenesis and treatment of atopic dermatitis has been added to help inform veterinarians who treat pets with dermatologic conditions. NEW! Revised content on cancer immunology reflects the vast expansion of information that has been uncovered in the past five years. NEW! Expanded information on the role of nutrition in animal immunity offers a rational basis for examining data of those who claim nutritional benefits. NEW! Full-color histologic images replace black and white images to more effectively convey concepts.
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ISBN:
Category : Gas manufacture and works
Languages : en
Pages : 1132
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Author: Jack S. Remington
Publisher: Elsevier Health Sciences
ISBN: 1437736378
Category : Medical
Languages : en
Pages : 1275
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Book Description
Infectious Diseases of the Fetus and Newborn Infant, written and edited by Drs. Remington, Klein, Wilson, Nizet, and Maldonado, remains the definitive source of information in this field. The 7th edition of this authoritative reference provides the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants. Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization of the fetus/mother. Nationally and internationally recognized in immunology and infectious diseases, new associate editors Nizet and Maldonado bring new insight and fresh perspective to the book. Get the latest information on maternal infections when they are pertinent to the infant or developing fetus, including disease transmission through breastfeeding Diagnose, prevent, and treat neonatal infectious diseases with expert guidance from the world's leading authorities and evidence-based recommendations. Incorporate the latest findings about infections found in utero, during delivery, and in the neonatal period. Find the critical answers you need quickly and easily thanks to a consistent, highly user-friendly format Get fresh perspectives from two new associate editors—Drs. Yvonne Maldonado, head of the Pediatric Infectious Disease program at Stanford, and Victor Nizet, Professor of Pediatrics & Pharmacy at University of California, San Diego and UCSD School of Medicine. Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother. Overcome the clinical challenges in developing countries where access to proper medical care is limited. Apply the latest recommendations for H1N1 virus and vaccines. Identify and treat infections with the latest evidence-based information on fighting life-threatening diseases in the fetus and newborn infants.
Author: David Male
Publisher: Elsevier Health Sciences
ISBN: 0702078468
Category : Medical
Languages : en
Pages : 527
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Book Description
Covering all the basic and clinical concepts you need to know for your coursework and USMLEs, Immunology, 9th Edition, offers a well-illustrated, carefully structured approach to this complex and fast-changing field. Carefully edited and authored by experts in both teaching and research, it provides cutting-edge, consistent coverage that links the laboratory and clinical practice. A user-friendly, color-coded format, including key concept boxes, explanatory diagrams, and nearly 200 photos to help you visually grasp and retain challenging concepts. Explains the building blocks of the immune system - cells, organs, and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context. Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more. Features a reorganized format that presents immunology in the order in which is typically taught and learned, better integrating basic and clinical immunology. Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer. Provides Critical Thinking boxes, chapter-opening summaries, and case-based and USMLE-style questions that provide effective review and quick practice for exams – plus more learning opportunities online, including USMLE-style questions and clinical cases. Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more. Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.
