Author: Nicole F. Steinmetz
Publisher: CRC Press
ISBN: 9814267945
Category : Technology & Engineering
Languages : en
Pages : 281
Book Description
This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Viral Nanoparticles
Author: Nicole F. Steinmetz
Publisher: CRC Press
ISBN: 9814267945
Category : Technology & Engineering
Languages : en
Pages : 281
Book Description
This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Publisher: CRC Press
ISBN: 9814267945
Category : Technology & Engineering
Languages : en
Pages : 281
Book Description
This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Viral and Antiviral Nanomaterials
Author: Devarajan Thangadurai
Publisher: CRC Press
ISBN: 1000318370
Category : Technology & Engineering
Languages : en
Pages : 456
Book Description
This book summarizes the synthesis, properties, characterization, and application of viral and antiviral nanomaterials by using interdisciplinary subjects ranging from materials science to biomedical science. Viral and Antiviral Nanomaterials: Synthesis, Properties, Characterization, and Application highlights attainments in utilizing nanomaterials as powerful tools for the treatment of viral infections in plants, animals, and humans. It reviews the adopted strategies for designing viral and antiviral nanomaterials for medical applications, including cancer therapy and drug delivery. It also explains the different kinds of antiviral nanosized structures, their chemistries, and the attributes that enable them to be suitable targets for nanotherapeutics. The contributors have prepared the content in a comprehensive manner for readers to use their research findings to improve the healthcare of all living beings. FEATURES Reviews the novel tools for synthesis and characterization of nanomaterials as viral and antiviral agents Explores the different applications of currently available nanomaterials for the treatment of viral infections Investigates the role of antiviral nanodrugs in human and plant systems Addresses the activity of nanostructures in drug-delivery systems for cancer treatment Allows readers from various backgrounds to access the advanced research and practices across traditional frontiers Discusses viral nanomaterials as the viable future of antiviral drugs and nanovaccines in animals and humans This authoritative book is of exceptional relevance to postgraduate scholars, researchers, and scientists interested in nanomedicine, biomedical science, materials science, biopharmaceutical technology, microbiology, and virology to improve virus- and cancer-based therapeutic tools for animal and human welfare.
Publisher: CRC Press
ISBN: 1000318370
Category : Technology & Engineering
Languages : en
Pages : 456
Book Description
This book summarizes the synthesis, properties, characterization, and application of viral and antiviral nanomaterials by using interdisciplinary subjects ranging from materials science to biomedical science. Viral and Antiviral Nanomaterials: Synthesis, Properties, Characterization, and Application highlights attainments in utilizing nanomaterials as powerful tools for the treatment of viral infections in plants, animals, and humans. It reviews the adopted strategies for designing viral and antiviral nanomaterials for medical applications, including cancer therapy and drug delivery. It also explains the different kinds of antiviral nanosized structures, their chemistries, and the attributes that enable them to be suitable targets for nanotherapeutics. The contributors have prepared the content in a comprehensive manner for readers to use their research findings to improve the healthcare of all living beings. FEATURES Reviews the novel tools for synthesis and characterization of nanomaterials as viral and antiviral agents Explores the different applications of currently available nanomaterials for the treatment of viral infections Investigates the role of antiviral nanodrugs in human and plant systems Addresses the activity of nanostructures in drug-delivery systems for cancer treatment Allows readers from various backgrounds to access the advanced research and practices across traditional frontiers Discusses viral nanomaterials as the viable future of antiviral drugs and nanovaccines in animals and humans This authoritative book is of exceptional relevance to postgraduate scholars, researchers, and scientists interested in nanomedicine, biomedical science, materials science, biopharmaceutical technology, microbiology, and virology to improve virus- and cancer-based therapeutic tools for animal and human welfare.
Multidisciplinary Science and Advanced Technologies
Author: Kaushik Pal
Publisher:
ISBN: 9781536189599
Category : Science
Languages : en
Pages : 0
Book Description
"Multidisciplinary Science and Advanced Technologies form a vast and diverse class of the engineering science and research divisions. This book discusses novel design techniques and smart mechanisms, as well as innovations that might be utilized in the future. Scientific modification can control industrial-scale assembly, a process that ultimately provides specific material function, depending on electronic development for advancements. Furthermore, the combination of supramolecular multidisciplinary technologies allows for the exploration of application-based materials. Smart materials are vital for the in-depth analysis of various morphologies. This book is an international forum for comprehensive soft-condensed matter physics, nanoscience principles, nanotechnology tools, and nanotechnology applications in the environmental, energy, and electronics sector, including a discussion of ethical issues in these fields. This book reviews the applications and market potential of a variety of media, including mirror, glazing, and display products, such as low-information content displays for banners and labels. The physicist, chemical engineer, materials scientist, nanotechnologist, and biologist at all levels, as well as academicians for unique device-based applications in various fields, will benefit from this book. Readers will gain an understanding of the practical and highly sensitive business fields for specific disciplinarians. The goal is to provide readers a broad review from a materials perspective, so that teachers can provide a comprehensive review of this technology to students. This book also highlights the entire gamut of smart engineering technologies and the materials design process of fabrications from past to present and future perspectives. The syllabi of various technical universities and research institutes are examined, explaining the basic perceptions of this emerging field. In science today, the major focus of research and development in synthetic materials and spectroscopic analysis broadly deals with materials on the atomic and molecular scales. The vision for the future is to move beyond these already existing applications and explore new realms of electronic applications"--
Publisher:
ISBN: 9781536189599
Category : Science
Languages : en
Pages : 0
Book Description
"Multidisciplinary Science and Advanced Technologies form a vast and diverse class of the engineering science and research divisions. This book discusses novel design techniques and smart mechanisms, as well as innovations that might be utilized in the future. Scientific modification can control industrial-scale assembly, a process that ultimately provides specific material function, depending on electronic development for advancements. Furthermore, the combination of supramolecular multidisciplinary technologies allows for the exploration of application-based materials. Smart materials are vital for the in-depth analysis of various morphologies. This book is an international forum for comprehensive soft-condensed matter physics, nanoscience principles, nanotechnology tools, and nanotechnology applications in the environmental, energy, and electronics sector, including a discussion of ethical issues in these fields. This book reviews the applications and market potential of a variety of media, including mirror, glazing, and display products, such as low-information content displays for banners and labels. The physicist, chemical engineer, materials scientist, nanotechnologist, and biologist at all levels, as well as academicians for unique device-based applications in various fields, will benefit from this book. Readers will gain an understanding of the practical and highly sensitive business fields for specific disciplinarians. The goal is to provide readers a broad review from a materials perspective, so that teachers can provide a comprehensive review of this technology to students. This book also highlights the entire gamut of smart engineering technologies and the materials design process of fabrications from past to present and future perspectives. The syllabi of various technical universities and research institutes are examined, explaining the basic perceptions of this emerging field. In science today, the major focus of research and development in synthetic materials and spectroscopic analysis broadly deals with materials on the atomic and molecular scales. The vision for the future is to move beyond these already existing applications and explore new realms of electronic applications"--
Viruses and Nanotechnology
Author: Marianne Manchester
Publisher: Springer Science & Business Media
ISBN: 3540693793
Category : Medical
Languages : en
Pages : 152
Book Description
Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.
Publisher: Springer Science & Business Media
ISBN: 3540693793
Category : Medical
Languages : en
Pages : 152
Book Description
Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.
Nanobiotechnology in Diagnosis, Drug Delivery and Treatment
Author: Mahendra Rai
Publisher: John Wiley & Sons
ISBN: 1119671795
Category : Science
Languages : en
Pages : 419
Book Description
Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.
Publisher: John Wiley & Sons
ISBN: 1119671795
Category : Science
Languages : en
Pages : 419
Book Description
Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.
Polymers and Nanomaterials for Gene Therapy
Author: Ravin Narain
Publisher: Woodhead Publishing
ISBN: 0081005210
Category : Science
Languages : en
Pages : 303
Book Description
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. - Explores current challenges in the research of genetic diseases - Discusses polymers for gene therapy and their function in designing advanced materials - Provides examples of organic and inorganic nanomaterials for gene therapy - Includes labeling, targeting, and assays - Looks at characterization, physico-(bio)chemical properties, and applications
Publisher: Woodhead Publishing
ISBN: 0081005210
Category : Science
Languages : en
Pages : 303
Book Description
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. - Explores current challenges in the research of genetic diseases - Discusses polymers for gene therapy and their function in designing advanced materials - Provides examples of organic and inorganic nanomaterials for gene therapy - Includes labeling, targeting, and assays - Looks at characterization, physico-(bio)chemical properties, and applications
Harnessing the Power of Viruses
Author: Boriana Marintcheva
Publisher: Academic Press
ISBN: 0128105151
Category : Science
Languages : en
Pages : 298
Book Description
Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. - Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions - Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena - Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes
Publisher: Academic Press
ISBN: 0128105151
Category : Science
Languages : en
Pages : 298
Book Description
Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. - Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions - Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena - Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes
Fundamentals of Nanoparticles
Author: Abdel Salam Hamdy Makhlouf
Publisher: William Andrew
ISBN: 0128135174
Category : Technology & Engineering
Languages : en
Pages : 668
Book Description
Fundamentals of Nanoparticles: Classifications, Synthesis Methods, Properties and Characterization explores the nanoparticles and architecture of nanostructured materials being used today in a comprehensive, detailed manner. This book focuses primarily on the characterization, properties and synthesis of nanoscale materials, and is divided into three major parts. This is a valuable reference for materials scientists, and chemical and mechanical engineers working in R&D and academia, who want to learn more about how nanoparticles and nanomaterials are characterized and engineered. Part one covers nanoparticles formation, self-assembly in the architecture nanostructures, types and classifications of nanoparticles, and signature physical and chemical properties, toxicity and regulations. Part two presents different ways to form nanometer particles, including bottom-up and top-down approaches, the classical and non-classical theories of nanoparticles formation and self-assembly, surface functionalization and other surface treatments to allow practical use. Part three covers characterization of nanoparticles and nanostructured materials, including the determination of size and shape, in addition to atomic and electronic structures and other important properties. - Includes new physical and chemical techniques for the synthesis of nanoparticles and architecture nanostructures - Features an in-depth treatment of nanoparticles and nanostructures, including their characterization and chemical and physical properties - Explores the unusual properties of materials that are developed by modifying their shape and composition and by manipulating the arrangement of atoms and molecules - Explains important techniques for the synthesis, fabrication and the characterization of complex nano-architectures
Publisher: William Andrew
ISBN: 0128135174
Category : Technology & Engineering
Languages : en
Pages : 668
Book Description
Fundamentals of Nanoparticles: Classifications, Synthesis Methods, Properties and Characterization explores the nanoparticles and architecture of nanostructured materials being used today in a comprehensive, detailed manner. This book focuses primarily on the characterization, properties and synthesis of nanoscale materials, and is divided into three major parts. This is a valuable reference for materials scientists, and chemical and mechanical engineers working in R&D and academia, who want to learn more about how nanoparticles and nanomaterials are characterized and engineered. Part one covers nanoparticles formation, self-assembly in the architecture nanostructures, types and classifications of nanoparticles, and signature physical and chemical properties, toxicity and regulations. Part two presents different ways to form nanometer particles, including bottom-up and top-down approaches, the classical and non-classical theories of nanoparticles formation and self-assembly, surface functionalization and other surface treatments to allow practical use. Part three covers characterization of nanoparticles and nanostructured materials, including the determination of size and shape, in addition to atomic and electronic structures and other important properties. - Includes new physical and chemical techniques for the synthesis of nanoparticles and architecture nanostructures - Features an in-depth treatment of nanoparticles and nanostructures, including their characterization and chemical and physical properties - Explores the unusual properties of materials that are developed by modifying their shape and composition and by manipulating the arrangement of atoms and molecules - Explains important techniques for the synthesis, fabrication and the characterization of complex nano-architectures
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
Author: Surendra Nimesh
Publisher: Woodhead Publishing
ISBN: 0081005636
Category : Medical
Languages : en
Pages : 258
Book Description
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. - Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies - Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. - Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
Publisher: Woodhead Publishing
ISBN: 0081005636
Category : Medical
Languages : en
Pages : 258
Book Description
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. - Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies - Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. - Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
Current Trends in the Identification and Development of Antimicrobial Agents
Author: M. Amin-ul Mannan
Publisher: Bentham Science Publishers
ISBN: 9815080067
Category : Science
Languages : en
Pages : 384
Book Description
Despite an increase in life expectancy over the past 20 years, the number of novel, multidrug resistant microorganisms has also risen dramatically. To reduce the risk of reemerging infections, and limit the spread of multidrug resistant microorganisms, it is urgently necessary to develop safe and effective therapeutic countermeasures. New antimicrobial chemicals are mostly produced with the help of microorganisms, and the bulk of medications now on the market are of this type. The use of high therapeutic screening and recent developments in analytical instrumentation has allowed the researchers to identify novel antimicrobial compounds from bacteria, fungi, plants, mushrooms, algae, and other sources more quickly. The second volume of Frontiers in Antimicrobial Agents highlights the ongoing requirement for researching and creating novel antimicrobial medications. Current Trends in the Identification and Development of Antimicrobial Agents aims to bring together the expertise of notable academics to examine all facets of antimicrobial research while keeping recent advancements in perspective. Antibiotic discovery, sources of novel antimicrobial chemicals, developing and reemerging microbial infections, various elements of drug resistance, and the need for antimicrobial medications in the future are all covered in this book. It is a timely reference for anyone involved in the discovery and development of new drugs, including microbiologists, biotechnologists, pharmacologists, doctors, and researchers.
Publisher: Bentham Science Publishers
ISBN: 9815080067
Category : Science
Languages : en
Pages : 384
Book Description
Despite an increase in life expectancy over the past 20 years, the number of novel, multidrug resistant microorganisms has also risen dramatically. To reduce the risk of reemerging infections, and limit the spread of multidrug resistant microorganisms, it is urgently necessary to develop safe and effective therapeutic countermeasures. New antimicrobial chemicals are mostly produced with the help of microorganisms, and the bulk of medications now on the market are of this type. The use of high therapeutic screening and recent developments in analytical instrumentation has allowed the researchers to identify novel antimicrobial compounds from bacteria, fungi, plants, mushrooms, algae, and other sources more quickly. The second volume of Frontiers in Antimicrobial Agents highlights the ongoing requirement for researching and creating novel antimicrobial medications. Current Trends in the Identification and Development of Antimicrobial Agents aims to bring together the expertise of notable academics to examine all facets of antimicrobial research while keeping recent advancements in perspective. Antibiotic discovery, sources of novel antimicrobial chemicals, developing and reemerging microbial infections, various elements of drug resistance, and the need for antimicrobial medications in the future are all covered in this book. It is a timely reference for anyone involved in the discovery and development of new drugs, including microbiologists, biotechnologists, pharmacologists, doctors, and researchers.