Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309453291
Category : Medical
Languages : en
Pages : 149
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Book Description
Advances in genetics and genomics are transforming medical practice, resulting in a dramatic growth of genetic testing in the health care system. The rapid development of new technologies, however, has also brought challenges, including the need for rigorous evaluation of the validity and utility of genetic tests, questions regarding the best ways to incorporate them into medical practice, and how to weigh their cost against potential short- and long-term benefits. As the availability of genetic tests increases so do concerns about the achievement of meaningful improvements in clinical outcomes, costs of testing, and the potential for accentuating medical care inequality. Given the rapid pace in the development of genetic tests and new testing technologies, An Evidence Framework for Genetic Testing seeks to advance the development of an adequate evidence base for genetic tests to improve patient care and treatment. Additionally, this report recommends a framework for decision-making regarding the use of genetic tests in clinical care.
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 396
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Book Description
WHILE HYDE hunts for a Variant-enhanced serial killer, a fight with a skin-eating granny almost sends Borland back into retirement. Skin eaters, secrets, and murder close in as the squad scrambles to contain the Variant Effect. VARION was a popular medication that could cure anything from Anxiety and Depression to Schizophrenia and Zoophagia. Everybody took it back in the day, because there were no side effects ... AT FIRST. By the time they learned about the Variant Effect it was too late. It’s been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now they have been ordered back into action to meet a terrifying new threat.
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 260
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Book Description
VARION was a popular medication that could cure anything from Anxiety and Depression to Schizophrenia and Zoophagia. Everybody took it back in the day, because there were no side effects... ...AT FIRST. By the time they learned about the Variant Effect it was too late. The old building in a rundown part of Metro was a perfect place to find a body, but they wouldn't have dragged Joe Borland out of retirement if it still had its skin. It's been 20 years since Borland battled the Variant Effect, and 20 since he let his partner get skinned alive. Now both of them are ordered back into action to meet a terrifying new threat.Description Notice: This Book is published by Historical Books Limited (www.publicdomain.org.uk) as a Public Domain Book, if you have any inquiries, requests or need any help you can just send an email to
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Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 31
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Book Description
BACK IN THE DAY ... People didn’t know that it was happening, so it was totally out of control by the time authorities understood that something serious was going on. As a result, the worst of it incubated in the shadows, hidden behind closed doors and far from view, where the true horror played out in isolation. Where no one could hear you scream. The Variant Effect was impossible to detect until you were already infected. There was no way to tell if it was near, if it was cooking in you, or if it had passed you by altogether. First responders were the first to document evidence of its existence, the first to see it happening, and often the first to feel it boiling in their blood. Stress set it off and fear fed it, so it was a perfect fit for cops, firemen, and EMTs. But in the beginning all they could do was file incident reports and wonder. Here is a short story from early in the day.
Author: Conxi Lázaro
Publisher: Academic Press
ISBN: 0128205202
Category : Medical
Languages : en
Pages : 438
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Book Description
Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency, functional evidence transcripts for RNA, proteins, and enzymes, somatic mutations, somatic profiling, and much more. - Compiles best practices, methods and sound evidence for DNA variant classification in one applied volume - Features chapter contributions from international leaders in the field - Includes practical examples of variant classification for common and rare disorders, and across clinical phenotypes
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 270
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Book Description
JOE BORLAND and Captain Beachboy deliver Lazarus team scientists to Bezo Metro Headquarters and find things in upheaval, so the rest of 9-Squad is ordered in to provide security. The Variant Squad has been shaken and bloodied over the last twenty-four hours with a rising body count, and there hasn’t been time for wounds to heal or for the dead recruits to be replaced. But the Bezo Board of Directors has put Lazarus specialists in charge of efforts to halt the Variant Effect outbreak in Metro, and end the Ziploc that holds the city in quarantine. The veterans Borland and Hyde are suspicious of the change in command but cannot override their questionable orders or abandon their squad to a dubious mission. As they prepare to join the scientists underground and open research labs that have been sealed for decades, 9-Squad finds the enigmatic company man, Brass, is working the graveyard shift and overseeing a top secret project of his own. Brass is in survival mode and his “Plan B” has hit a few bumps, but that’s not the worst of it. There have been reports of unusual sounds and sightings that lend some truth to the old rumors that the HQ basement levels are haunted. The squad must investigate the eerie phenomena, but all the signs point to something far more tangible and terrifying than the dead. Borland, Hyde and the frazzled 9-Squad must decide who they can trust as lethal forces gather, and avenues of escape begin to close. The only way to save their skins and protect the public from annihilation may involve a terrifying descent into darkness. Explore the MADHOUSE with Gas Light, second stage in the final chapters of The Variant Effect Series.
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 230
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Book Description
THE END BEGINS NOW! Just over a year has passed since the Variant Effect returned and Skin Eaters started hunting again. During the last six months Metro citizens have been quarantined with the National Guard at the gates ready to shoot anyone who tries to leave the city. The authorities have asked for calm but the panicked public knows a dangerous and more virulent form of the infection is moving through every neighborhood. The old Variant stationhouses have reopened to meet the threat, and the frantic fighters of 9-Squad are climbing the walls. Everyone’s a little on edge. The veteran Captain Hyde is recovering from a serial killer attack but the squad doubts his tortured mind will heal. Beachboy’s promotion to captain has intensified his “death wish” and Wizard is haunted by her part in their fatal love triangle. Joe Borland’s talent for carnage has given him something to live for, even if others have to pay for his survival with their lives. And ringleader Brass paces the cage wondering if he’s been accidentally imprisoned, or if his Bezo bosses have sentenced him to death with the rest. Good thing he’s been working on “Plan B.” Start on the ground floor of the MADHOUSE with Ziploc City, first step in the final chapters of The Variant Effect Series. NO ONE IS SANE SO NO ONE IS SAFE!
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 357
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Book Description
THE VARIANT SQUAD barely had time to get back on its feet before the screaming started. Someone was getting skinned alive, and they knew it. But many of their comrades have just fallen to their deaths, and others are still missing, so Captain Beachboy knows that answering the cry for help would be suicide. Skin Eater packs are still hunting on the levels above and below them, and it’s only a matter of time before their ugly craving returns and they attack again. And that’s not the end of it. A murderous Kill Squad sent by an unknown enemy must have followed them underground. It has the Lazarus team’s innocent blood on its hands, and Beachboy suspects the unknown assassins are committed to spilling 9-Squad’s too. And the old myths about the basement are proving true. Something with an appetite for pain is haunting the bunker complex and feeds its hunger through the Biter packs. It has also poisoned the place with the Varion molecule that causes the lethal new form of the Variant Effect, forcing the squad to remain sealed in their bag-suits. And they’re running out of air. Variant Squad veteran Joe Borland knows that there are forces within the squad that might not want to win the battle underground, and would prefer leaving his bagged-comrades buried with the incriminating evidence they have found. So he’ll have to pick a side when his life’s on the line. In the meantime he and Beachboy take the squad survivors on a desperate search for a rumored escape tunnel while dark forces gather on all sides, and a secret clock winds down to doomsday and the final Variant Squad protocol of Ziploc, Gas and BURN! Explore the MADHOUSE to the END with BURN, third stage in the final chapters of The Variant Effect Series.
Author: National Research Council
Publisher: National Academies
ISBN: 0309039959
Category : Science
Languages : en
Pages : 436
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Book Description
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 1119429250
Category : Science
Languages : en
Pages : 1740
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Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
