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Author: Alexander Birbrair
Publisher: Academic Press
ISBN: 0128238836
Category : Science
Languages : en
Pages : 338
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Book Description
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson's disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics - Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson's disease, graft vs. host disease, and much more - Contributed by world-renown experts in the field
Author: Alexander Birbrair
Publisher: Academic Press
ISBN: 0128238836
Category : Science
Languages : en
Pages : 338
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Book Description
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson's disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics - Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson's disease, graft vs. host disease, and much more - Contributed by world-renown experts in the field
Author: S. Gupta
Publisher: Springer Science & Business Media
ISBN: 9780792387763
Category : Medical
Languages : en
Pages : 386
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Book Description
In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.
Author: American Psychiatric Association
Publisher:
ISBN: 9788184485424
Category : Mental illness
Languages : en
Pages : 943
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Book Description
Author: Waguih William IsHak
Publisher: Springer Nature
ISBN: 3031154010
Category : Medical
Languages : en
Pages : 868
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Book Description
This atlas is the first fully visual reference to cover psychiatry broadly, appealing to psychiatric as well as non-psychiatric clinicians and trainees who need an easy-to-use visual resource with holistic approach to patient care. Written by expert clinicians and educators, this text describes basic clinical and scholarly information across the field utilizing an easy-to-understand format. The rich figures and tables describe etiology, pathophysiology, phenomenology, and treatment even in areas that are difficult to illustrate, including substance-related disorders, neurodegenerative diseases, personality disorders, and others. The visual approach proves valuable to some of the most innovative techniques in psychiatry, including implications for neuroimaging. Comprehensive and unique, Atlas of Psychiatry is a landmark reference for all medical practitioners looking for an intricate yet accessible visual resource.
Author: Elizabeth D. Buttermore
Publisher: Academic Press
ISBN: 0128222786
Category : Medical
Languages : en
Pages : 374
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Book Description
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification. - Discusses techniques and new technology for iPSC culturing and neuronal differentiation to establish best practices in the lab - Outlines considerations for phenotypic assay development - Provides information about the successes, failures, and implications of phenotyping and screening with iPSC-derived neurons - Describes how human iPSC-derived neurons are being used for preclinical discovery research as well as the development of therapeutics utilizing hiPSC-derived neurons
Author: Theodore P. Beauchaine
Publisher: Oxford University Press
ISBN: 0199324689
Category : Psychology
Languages : en
Pages : 545
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Book Description
Recent developments in the conceptualization of externalizing spectrum disorders, including attention-deficit/hyperactivity disorder, conduct disorder, antisocial personality disorder, and substance use disorders, suggest common genetic and neural substrates. Despite this, neither shared vulnerabilities nor their implications for developmental models of externalizing conduct are captured by prevailing nosologic and diagnostic systems, such as the DSM-5. The Oxford Handbook of Externalizing Spectrum Disorders is the first book of its kind to capture the developmental psychopathology of externalizing spectrum disorders by examining causal factors across levels of analysis and developmental epochs, while departing from the categorical perspective. World renowned experts on externalizing psychopathology demonstrate how shared genetic and neural vulnerabilities predispose to trait impulsivity, a highly heritable personality construct that is often shaped by adverse environments into increasingly intractable forms of externalizing conduct across development. Consistent with contemporary models of almost all forms of psychopathology, the Handbook emphasizes the importance of neurobiological vulnerability and environmental risk interactions in the expression of externalizing behavior across the lifespan. The volume concludes with an integrative, ontogenic process model of externalizing psychopathology in which diverse equifinal and multifinal pathways to disorder are specified.
Author: Vasilis Vasiliou
Publisher: Springer
ISBN: 3319096141
Category : Medical
Languages : en
Pages : 445
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Book Description
In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.
Author: Mikhail Pletnikov
Publisher: Academic Press
ISBN: 012801184X
Category : Psychology
Languages : en
Pages : 550
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Book Description
Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader's understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. - Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models - Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia - Edited and authored by leading researchers in the field of schizophrenia and related psychoses
Author: Bernhard Baune
Publisher: Academic Press
ISBN: 0128131772
Category : Medical
Languages : en
Pages : 594
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Book Description
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Author: James E. Barrett
Publisher: Cambridge University Press
ISBN: 1139510304
Category : Medical
Languages : en
Pages : 379
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Book Description
Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.
