UTILISATION, TOXICITE ET EFFETS SECONDAIRES DES ANTI-INFLAMMATOIRES NON STEROIDIENS, ACTUALITES PDF Download
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Author: Sandrine GOLDMAN-MOTTET
Publisher:
ISBN:
Category :
Languages : fr
Pages : 108
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Book Description
Les AINS, malgré une grande diversité chimique, ont la propriété commune de bloquer la cyclo-oxygénase (COX), enzyme responsable de la formation de prostaglandines. Celles-ci, outre leur rôle pro-inflammatoire, ont un rôle physiologique important et leur inhibition est à l'origine de la plupart des effets indésirables des AINS. Ceux-ci sont principalement digestifs et rénaux mais également hématologiques, hépatiques et génitaux. Il faut également souligner la toxicité potentielle des AINS et des antalgiques en particulier chez le chat, qui du fait d'une glucuronoconjugaison déficiente, est extrêmement sensible au paracétamol et à l'acide flufénamique. La découverte de 2 isoformes de la cyclo-oxygénase (COX1 : synthèse de prostaglandines à rôles physiologiques et COX2 : synthèse de prostaglandines à rôles pro-inflammatoires), a permis le développement de molécules inhibant préférentiellement (voire uniquement) la COX2 et dont les effets indésirables sont réduits. Parallèlement, la découverte de substances, les "doubles inhibiteurs", capables d'inhiber à la fois la COX et la 5-LOX (responsable de la formation de leucotriènes, pro-inflammatoires), est à l'origine du développement de nouveaux AINS qui semblent allier efficacité et grande sécurité d'emploi. Une bonne connaissance du mode d'action associée à un emploi raisonné de ces molécules va permettre une utilisation plus sécurisante dans de nombreuses indications : affections ostéo-articulaires, chirurgie, pneumologie, ophtalmologie.
Author: Sandrine GOLDMAN-MOTTET
Publisher:
ISBN:
Category :
Languages : fr
Pages : 108
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Book Description
Les AINS, malgré une grande diversité chimique, ont la propriété commune de bloquer la cyclo-oxygénase (COX), enzyme responsable de la formation de prostaglandines. Celles-ci, outre leur rôle pro-inflammatoire, ont un rôle physiologique important et leur inhibition est à l'origine de la plupart des effets indésirables des AINS. Ceux-ci sont principalement digestifs et rénaux mais également hématologiques, hépatiques et génitaux. Il faut également souligner la toxicité potentielle des AINS et des antalgiques en particulier chez le chat, qui du fait d'une glucuronoconjugaison déficiente, est extrêmement sensible au paracétamol et à l'acide flufénamique. La découverte de 2 isoformes de la cyclo-oxygénase (COX1 : synthèse de prostaglandines à rôles physiologiques et COX2 : synthèse de prostaglandines à rôles pro-inflammatoires), a permis le développement de molécules inhibant préférentiellement (voire uniquement) la COX2 et dont les effets indésirables sont réduits. Parallèlement, la découverte de substances, les "doubles inhibiteurs", capables d'inhiber à la fois la COX et la 5-LOX (responsable de la formation de leucotriènes, pro-inflammatoires), est à l'origine du développement de nouveaux AINS qui semblent allier efficacité et grande sécurité d'emploi. Une bonne connaissance du mode d'action associée à un emploi raisonné de ces molécules va permettre une utilisation plus sécurisante dans de nombreuses indications : affections ostéo-articulaires, chirurgie, pneumologie, ophtalmologie.
Author: Sandrine Goldman-Mottet
Publisher:
ISBN:
Category :
Languages : fr
Pages : 125
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Book Description
Author: Pierre Beaulieu
Publisher: Lippincott Williams & Wilkins
ISBN: 1496331915
Category : Medical
Languages : en
Pages : 978
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Book Description
Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Author: Karel Pacak
Publisher: John Wiley & Sons
ISBN: 0470766387
Category : Medical
Languages : en
Pages : 184
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Book Description
Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis. Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas – providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine. The most comprehensive book on pheochromocytoma Provides cutting edge science and clinical guidance Written by the leading names in the field Authors present their recently developed novel biochemical test for the diagnosis of Pheochromocytoma
Author: World Health Organization
Publisher:
ISBN: 9789241548120
Category : Medical
Languages : en
Pages : 166
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Book Description
These guidelines have been developed to support countries to relieve pain in their paediatric populations. These guidelines address persisting pain in children caused by conditions such as cancer, HIV/AIDS, sickle-cell disease, burns, trauma, and phantom limb pain. Recommendations -- developed following a careful and transparent appraisal of available evidence -- are presented for the pharmacological treatment of mild, moderate and severe pain. The guidelines include chapters on the various systems used to classify pain and on the evaluation of pain, which reviews the available tools for routine pain measurement in children. Provision of sustainable pain relief within health care systems is covered in a separate chapter. Since morphine and other opioid analgesics -- required for the relief of moderate-to-severe pain in children -- are listed under the 1961 UN Single Convention on Narcotic Drugs, the new guidelines include an annex explaining the Convention's requirements for the handling and procurement of opioid analgesics for the relief of pain.
Author: Louis Sanford Goodman
Publisher: McGraw Hill Professional
ISBN: 0071443436
Category : Medical
Languages : en
Pages : 1232
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Book Description
Put the authority of Goodman & Gilman's in the palm of your hand! 5 STAR DOODY'S REVIEW! "...the most authoritative and trusted source of pharmacological information, has now spawned a portable pocket drug guide....This manual extracts the essential core drug information from the eleventh edition of the parent book, referring the reader to the online version of the parent book for historical aspects, many chemical and clinical details, and additional figures and references. This makes G & G a very useful book. This will be of use to individuals in training or practice in the fields of pharmacy, medicine, nursing, or allied health disciplines where knowledge of drug actions are important....Each chapter provides the core essential information provided in the parent book in a very readable format. Readers can use this easy to handle and read manual for essential information along with the online version of the parent book as a reference for more in-depth specific information on drugs."--Doody's Review Service The Goodman & Gilman Manual of Pharmacology and Therapeutics offers the renowned content of Goodman & Gilman's Pharmacological Basis of Therapeutics, Eleventh Edition, condensed into an ultra-handy, streamlined reference. More than just a pocket drug guide, this indispensable resource offers: A carry-along source of essential fundamental information, with all the authority of Goodman & Gilman's Pharmacological Basis of Therapeutics, Eleventh Edition The benefits of the world's leading pharmacology text in a convenient, portable format Comprehensive, yet streamlined and clinically relevant coverage of the pharmacological basis of therapeutics High-yield overview of pharmacokinetics, pharmacodynamics, and the foundations of pharmacology Expert insights into the properties, mechanisms, and uses of all the major drug classes Considerations of vital patient-specific issues
Author: Urban Laffer
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Business & Economics
Languages : en
Pages : 80
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Book Description
Author: Robert Terkeltaub
Publisher: Elsevier Health Sciences
ISBN: 1455727105
Category : Medical
Languages : en
Pages : 374
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Book Description
Gout and Other Crystal Arthropathies, by Dr. Robert Terkeltaub, presents the state-of-the-art, clinically-focused coverage you need to manage these increasingly prevalent diseases. Diagnose the full range of crystal arthropathies—including pseudogout, intercritical gout, hyperuricemia, and gouty arthritis—and treat your patients effectively with discussions of recently-approved drugs like Uloric and those currently under review, such as Kristexxa and Colcryst. With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and crystal-induced arthropathies. Stay current on recent developments such as uricosuric therapy and inhibitor therapy; gout flare prophylaxis and colchicines; ultrasound in the diagnosis of crystal deposition diseases; imaging of gout, CPPD, and hydroxyapatitie deposition diseases; and uricase therapy of gout. Manage the full range of crystal arthropathies with 25 clinically-focused chapters on pseudogout, intercritical gout, hyperuricemia, gouty arthritis, and more. Treat your patients effectively using the latest information on drug treatments, from the recently-approved Uloric to Kristexx and Colcryst, which are still under review.
Author: Nathan I. Cherny
Publisher: Oxford University Press, USA
ISBN: 0199656096
Category : Medical
Languages : en
Pages : 1281
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Book Description
Emphasising the multi-disciplinary nature of palliative care the fourth edition of this text also looks at the individual professional roles that contribute to the best-quality palliative care.
Author: Carol A. Kauffman
Publisher: Springer Science & Business Media
ISBN: 1441966404
Category : Medical
Languages : en
Pages : 542
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Book Description
Clinical Mycology offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.
