Use of Functionalized Hydrogels for Rapid Re-epithelialization of Hybrid Implants in Tissue Engineering PDF Download
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Author: Saït Ciftci
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
As part of the development of an artificial larynx, in vivo experiments and clinical trials have revealed a defect in re-epithelialization of the endoluminal side of the prosthesis. This respiratory epithelium is absolutely necessary to obtain an implantable device fully integrated into the body but also for the functionality of such an implant. In this work we have developed patches of interpenetrated and reticulated hydrogels based on collagen and hyaluronic acid to ensure rapid epithelial regrowth. These optimized hydrogel patches have sufficient resistance to hydrolysis to limit their early degradation once implanted. They have been functionalized by growth and cell differentiation factors that are released gradually with an objectified result on cell proliferation. Encapsulation of immune cells and the use of cytokines in these gels also modulate the inflammatory response towards a healing process rather than rejection.
Author: Saït Ciftci
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
As part of the development of an artificial larynx, in vivo experiments and clinical trials have revealed a defect in re-epithelialization of the endoluminal side of the prosthesis. This respiratory epithelium is absolutely necessary to obtain an implantable device fully integrated into the body but also for the functionality of such an implant. In this work we have developed patches of interpenetrated and reticulated hydrogels based on collagen and hyaluronic acid to ensure rapid epithelial regrowth. These optimized hydrogel patches have sufficient resistance to hydrolysis to limit their early degradation once implanted. They have been functionalized by growth and cell differentiation factors that are released gradually with an objectified result on cell proliferation. Encapsulation of immune cells and the use of cytokines in these gels also modulate the inflammatory response towards a healing process rather than rejection.
Author: Thakur Raghu Raj Singh
Publisher: CRC Press
ISBN: 1351648276
Category : Medical
Languages : en
Pages : 289
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Book Description
Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.
Author: Shahid Ali Khan
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3111334228
Category : Technology & Engineering
Languages : en
Pages : 185
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Book Description
With the advancement in medicinal chemistry and material science, several highly specific, biocompatible and non-toxic therapeutic agents have been discovered and successfully applied for various clinical applications. Many of the conventional constraints of clinical therapies have been replaced and overcome by the multifaceted applications of material science and nanotechnology. Recently, material science-based therapeutic agents are the major global pharmaceutical market and are believed to mount exponentially shortly. Among the various therapeutic agents, hydrogels are one of the most widely applied materials used in the treatment of various diseases, and one of the most diverse materials that are used for multipurpose applications. Hydrogels were the first biomaterials used for Human being. Hydrogels are polymeric linkages, water-insoluble, however, sometimes established as a colloidal gel in water. Hydrogels are the superabsorbent materials because it can absorb more than 90% water, and hence regarded as natural living tissue. Mechanically strong hydrogels were synthesized by the advent of new synthetic strategies. Owing to the swollen properties, three-dimensional polymer network, and strong mechanical characteristics, these are widely used in catalysis, adsorption, drug delivery systems for proteins, contact lenses, wound dressings, wound healing, bone regeneration, tissue engineering, baby diapers, food rheology, and many others. Due to their diverse applications, hydrogels are considered one of the smartest materials in pharmaceutics, and are eco-friendly materials, cheap, and have good recyclability. They are used as therapeutic agents in different health sectors. As they are very sensitive to target, therefore it is considered favorite and preferred choice in biomedical sectors. Patients are psychologically scared of surgeries regarding huge expenses and failure. So researchers are working on hydrogels as alternative surgical replacement. In most cases, they have successfully achieved research on hydrogels in bones and tissues repairment. It might be hope of life for serious patients in future. The domain of this work will cover state of the art potentials and applications in various technological areas.
Author: Anujit Ghosal
Publisher: CRC Press
ISBN: 1000056147
Category : Technology & Engineering
Languages : en
Pages : 164
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Book Description
This book explores the potential of hydrogels as a multiutility system and their benefits (biocompatibility, degradability, and supporting scaffolds) for a wide range of applications in diagnostics and therapeutics. It also discusses the future prospects and challenges facing hydrogels. A wide variety of smart hydrogels (conducting, stimuli responsive, and others) with possible biomedical applications are elaborated. The book demonstrates the effectiveness of hydrogels in diagnostics of diseases in various in vivo and in vitro environments and highlights the engineering/functionalization of hydrogels for everyday drug dosage as an efficient drug carrier, scaffold, and sensing application. Explores the potential of hydrogels as a multifunctional system and their benefits, particularly for biomedical applications in diagnostics as well as therapeutics. Highlights the designing and engineering of hydrogels for everyday drug dosage and possible functionalization to fabricate an efficient drug carrier. Examines the significance of biopolymer-based hydrogels and their responsiveness in different physiological fluids. Demonstrates the effectiveness of hydrogels in diagnostics of diseases in various in,vivo and in,vitro environments. Presents challenges associated with the hydrogels and discusses possible in-hand modifications at length. Dr. Anujit Ghosal worked in the School of Biotechnology, Jawaharlal Nehru University, India. Currently, he is affiliated with the School of Life Sciences, Beijing Institute of Technology, Beijing, PRC. Dr. Ghosal researches in biochemistry, polymer chemistry, and nanotechnology. He has been the recipient of prestigious fellowships throughout his research career. His research ability is proven by his published peer-reviewed research and review articles and contributed book chapters. Dr. Ajeet Kaushik works as an assistant professor of chemistry and is exploring advanced electrochemical sensing systems and nanomedicine for personalized health wellness at the Department of Natural Sciences of the Division of Science, Arts, and Mathematics at Florida Polytechnic University, Lakeland, US. He is the recipient of various reputed awards for his service in the area of nanobiotechnology for health care. His excellent research credentials are reflected by his four edited books, 100 international research peer-reviewed publications, and three patents in the area of nanomedicine and smart biosensors for personalized health care.
Author: Zhenwei Ma
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
"Hydrogel adhesion with both synthetic biomaterials and biological tissues has significant implications in biomedical device functionalization and regenerative medicine. Devices strongly bonded with tough yet soft tissue-mimetic hydrogels, when interfaced with tissues in human body, can remedy the damage and irritation caused by the mechanically mismatched stiff biomaterials. The robust integration of such hydrogels with damaged or degenerated tissues can further serve as a functional interface and therapeutic intervention strategy to potentially accelerate tissue healing and rehabilitation. However, it remains a major challenge to achieve tough wet adhesion between hydrogels and other materials. In clinical settings, even more hurdles need to be overcome considering the stringent regulations on the biocompatibility of the hydrogels/devices and the complex biomechanical environment they may encounter in vivo. To this end, this thesis focuses on the multifaceted design and engineering of tough adhesion between hydrogels, tissues, and biomedical devices, and explores the functionalization of the hybrid devices for advanced wound management. First, we propose a new paradigm to engineer tough bioadhesion of hydrogels with unprecedented controllability. Our strategy leverages low-frequency ultrasound (US) and various anchoring primer materials (nanoparticles, proteins and polymers) to form tough adhesion between hydrogels and tissues spatiotemporally without any chemical reactions. We discover that the highly localized and transient effects of US-induced cavitation enable spatial control of tough bioadhesion, validated by both experiments and finite element simulations. We further demonstrate the on-demand removal of bioadhesives using US and their applications for sustained transdermal drug delivery. Next, inspired by tendon endotenon sheath, we propose a versatile strategy to functionalize fiber-based devices such as sutures. This strategy seamlessly unites surgical sutures, tough gel sheath, and various functional materials. Robust modification is demonstrated with their strong interfacial adhesion. The surface stiffness, friction, and drag of the suture when contacted with tissues can be markedly reduced, without compromising the tensile strength. Versatile functionalization of the suture for infection prevention, wound monitoring, drug delivery, and near-infrared imaging is then presented. The last part of the thesis proposes a novel design of gel adhesive puncture-sealing (GAPS) suture device for tissue closure and sealing. Applied at its dry state, the GAPS suture device can rapidly swell and adhere to the surrounding tissues to seal the puncture hole. We study the constrained swelling of hydrogels and the achieved tissue adhesion energy with experimental analysis. We further highlight various advantages of the GAPS sutures for the repair of mechanically active meniscus tissues ex vivo, by preventing gap formation, stress concentration and local tissue damage owing to the achieved strong integration of tissue, hydrogel, and biomaterial"--
Author: Rolando Barbucci
Publisher: Springer
ISBN: 9788847011038
Category : Science
Languages : en
Pages : 197
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Book Description
The studies on Biohydrogels have had a rapid, exponential evolution in the last decades. This book is the result of an International conference gathering the most recent results in this field.
Author: Dany Jair Munoz Pinto
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Jun Li
Publisher: Springer
ISBN: 9783662575093
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
This book introduces readers to the latest advances in hydrogel biomaterials, mainly focusing on the emerging areas of synthetic and biopolymer hydrogels formed through specially designed chemical or physical crosslinking, and the cyclodextrin-based host-guest supramolecular self-assembly, for cell encapsulation, cell expansion, cell differentiation and tissue repair, stem cell culture, and cellular therapy and drug delivery applications. The book was written by experts at the forefront of these interdisciplinary areas and is intended for all researchers working in the fields of biomaterials and biomedical engineering, as well as medical professions. Jun Li is a Professor at the Department of Biomedical Engineering, National University of Singapore, Singapore. Yoshihito Osada is a Professor at RIKEN Advanced Science Institute, Japan. Justin Cooper-White is a Professor at the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Australia.
Author: J. Miguel Oliveira
Publisher: Academic Press
ISBN: 0128242256
Category : Science
Languages : en
Pages : 851
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Book Description
Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field. - Reviews the fundamentals and recent advances of hydrogels in tissue engineering and regenerative medicine applications - Presents state-of-the-art methodologies for the synthesis and processing of different types of hydrogels - Includes contributions by leading experts in engineering, the life sciences, microbiology and clinical medicine
Author: Marta Sáez Ríos
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The aim of this project was to develop a multifunctional alginate-based hydrogel modified with peptide-functionalized gold nanoparticles (AuNPs). Hydrogels are versatile materials, commonly used in tissue engineering due to their biocompatibility and tunable properties. In detail, this project explored the modification of alginate hydrogels with functionalized AuNPs incorporating bioactive peptides, such as LF1-11 or RGD, which are known for preventing bacterial infection and promoting cell adhesion, respectively. To this end, this project focused on the synthesis of AuNPs, their conjugation with peptides and, finally, the hybrid hydrogel preparation. In order to optimize and characterize the fabrication process, several physicochemical techniques were used such as UV-visible spectroscopy, transmission electron microscopy or X-ray photoelectron spectroscopy. The synthesis of the hybrid biomaterial was successfully executed and optimized at each step. The fabrication of this hybrid hydrogel proved to be a robust procedure and highly reproducible. Interestingly, the presence of the antimicrobial peptide LF1-11 decreased the adhesion of bacteria to the hydrogel. Further bacterial and cellular assays are thus warranted in order to ascertain the potential applications of this new biomaterial, e.g. as a film/dressing for infected and chronic wounds or injectable gel for bone defects.
