Author: Klaus Jung
Publisher: Springer Science & Business Media
ISBN: 3642843131
Category : Medical
Languages : en
Pages : 329
Book Description
Interest and research in urinary enzymology were incited about three decades ago by reports that urinary enzymes are elevated in diseases of the kidney and urinary tract. Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. Recognition of the quantitative distribution of enzymes in the various anatomical and functional parts of the nephron and advances in our understanding of the handling of proteins by the kidney have made it possible to associate urinary enzyme activity patterns with physiological and pathophysio logical functions of the nephron. Confidence in the diagnostic value of urinary enzymes is not unanimous among clinicians and among scientists. The main reason for the difference in opinion may well be that the variability in data exceeds the variability one is accustomed to in the diagnostic enzymology of blood plasma enzymes. In contrast to plasma enzymes, which are protected by an "enzyme friendly" milieu, enzymes released into the urine encounter an "enzyme hostile" environ ment: no or little protective protein, variable pH, variable volume, variable metabolite and salt concentrations, variable concentrations of enzyme in hibitors. Through advances in methodology some of these factors can now be controlled; standardization of urine collection periods and preanalytical treat ment are as important as optimization of assay methods.
Urinary Enzymes
Author: Klaus Jung
Publisher: Springer Science & Business Media
ISBN: 3642843131
Category : Medical
Languages : en
Pages : 329
Book Description
Interest and research in urinary enzymology were incited about three decades ago by reports that urinary enzymes are elevated in diseases of the kidney and urinary tract. Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. Recognition of the quantitative distribution of enzymes in the various anatomical and functional parts of the nephron and advances in our understanding of the handling of proteins by the kidney have made it possible to associate urinary enzyme activity patterns with physiological and pathophysio logical functions of the nephron. Confidence in the diagnostic value of urinary enzymes is not unanimous among clinicians and among scientists. The main reason for the difference in opinion may well be that the variability in data exceeds the variability one is accustomed to in the diagnostic enzymology of blood plasma enzymes. In contrast to plasma enzymes, which are protected by an "enzyme friendly" milieu, enzymes released into the urine encounter an "enzyme hostile" environ ment: no or little protective protein, variable pH, variable volume, variable metabolite and salt concentrations, variable concentrations of enzyme in hibitors. Through advances in methodology some of these factors can now be controlled; standardization of urine collection periods and preanalytical treat ment are as important as optimization of assay methods.
Publisher: Springer Science & Business Media
ISBN: 3642843131
Category : Medical
Languages : en
Pages : 329
Book Description
Interest and research in urinary enzymology were incited about three decades ago by reports that urinary enzymes are elevated in diseases of the kidney and urinary tract. Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. Recognition of the quantitative distribution of enzymes in the various anatomical and functional parts of the nephron and advances in our understanding of the handling of proteins by the kidney have made it possible to associate urinary enzyme activity patterns with physiological and pathophysio logical functions of the nephron. Confidence in the diagnostic value of urinary enzymes is not unanimous among clinicians and among scientists. The main reason for the difference in opinion may well be that the variability in data exceeds the variability one is accustomed to in the diagnostic enzymology of blood plasma enzymes. In contrast to plasma enzymes, which are protected by an "enzyme friendly" milieu, enzymes released into the urine encounter an "enzyme hostile" environ ment: no or little protective protein, variable pH, variable volume, variable metabolite and salt concentrations, variable concentrations of enzyme in hibitors. Through advances in methodology some of these factors can now be controlled; standardization of urine collection periods and preanalytical treat ment are as important as optimization of assay methods.
Urinary Enzymes in Clinical and Experimental Medicine
Author: Klaus Jung
Publisher: Springer Verlag
ISBN: 9780387531885
Category : Medical
Languages : en
Pages : 326
Book Description
Publisher: Springer Verlag
ISBN: 9780387531885
Category : Medical
Languages : en
Pages : 326
Book Description
Diagnostic Significance of Enzymes and Proteins in Urine
Author: Ulrich Christian Dubach
Publisher:
ISBN:
Category : Clinical enzymology
Languages : en
Pages : 392
Book Description
Publisher:
ISBN:
Category : Clinical enzymology
Languages : en
Pages : 392
Book Description
Enzymes in Urine and Kidney, Edited by U.C. Dubach. [Proceedings of the International Conference on Enzymes in Urine, Rheinfelden, Switzerland, 13-14th Oct. 1967].
Author: International Conference on Enzymes in Urine, Rheinfelden, 1967
Publisher:
ISBN:
Category : Clinical enzymology
Languages : en
Pages : 308
Book Description
Publisher:
ISBN:
Category : Clinical enzymology
Languages : en
Pages : 308
Book Description
Enzymes in Urine and Kidney: Proceedings of the ... Conference ...
Author: rheinfelden International conference on enzymes in urine
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Enzymes in Urine and Kidney
Author: Ulrich Christian Dubach
Publisher:
ISBN:
Category : Enzymes
Languages : en
Pages : 316
Book Description
Publisher:
ISBN:
Category : Enzymes
Languages : en
Pages : 316
Book Description
Chronic Kidney Disease, Dialysis, and Transplantation E-Book
Author: Jonathan Himmelfarb
Publisher: Elsevier Health Sciences
ISBN: 0323531725
Category : Medical
Languages : en
Pages : 768
Book Description
Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms.
Publisher: Elsevier Health Sciences
ISBN: 0323531725
Category : Medical
Languages : en
Pages : 768
Book Description
Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms.
Biologic Markers in Urinary Toxicology
Author: Subcommittee on Biologic Markers in Urinary Toxicology
Publisher: National Academies Press
ISBN: 0309587794
Category : Science
Languages : en
Pages : 322
Book Description
Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).
Publisher: National Academies Press
ISBN: 0309587794
Category : Science
Languages : en
Pages : 322
Book Description
Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).
The Assessment of Kidney Damage by Urinary Enzymes
Author: David Kayode Obatomi
Publisher:
ISBN:
Category :
Languages : en
Pages : 688
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 688
Book Description
Biologic Markers in Urinary Toxicology
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309052289
Category : Science
Languages : en
Pages : 322
Book Description
Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).
Publisher: National Academies Press
ISBN: 0309052289
Category : Science
Languages : en
Pages : 322
Book Description
Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).