Updates on Osteoimmunology: What’s New on the Crosstalk Between Bone and Immune Cells PDF Download
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Author: Giacomina Brunetti
Publisher: Frontiers Media SA
ISBN: 2889636135
Category :
Languages : en
Pages : 160
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Book Description
Author: Giacomina Brunetti
Publisher: Frontiers Media SA
ISBN: 2889636135
Category :
Languages : en
Pages : 160
Get Book
Book Description
Author: Giacomina Brunetti
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
In the last twenty years, different discoveries have emphasized the cross-talk between bone and immune cells as well as their common regulatory pathways. Indeed, soluble molecules produced by immune cells modulate the behavior of osteoblasts and osteoclasts. Moreover, osteoclasts, the bone-resorbing cells, originate from the same myeloid precursor cells that differentiated into macrophages and myeloid dendritic cells. Whereas, the bone-forming osteoblastic cells control hematopoietic stem cell niches and thus immune cell ontology. The amplified recognition of the complex relationship between the immune system and bone led to the designation of osteoimmunology field. This Research Topic collects articles that highlight the cross-talk between bone and immune cells,
Author: Joseph Lorenzo
Publisher: Academic Press
ISBN: 0128006277
Category : Medical
Languages : en
Pages : 376
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Book Description
Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis. Explains the intricate interaction between the immune system and bone Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems
Author: Yongwon Choi
Publisher: Springer Science & Business Media
ISBN: 1441910506
Category : Medical
Languages : en
Pages : 135
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Book Description
It has only recently been appreciated that the immune and skeletal systems have major interactions. It is now well documented that osteoclasts, which are important cellular mediators of skeletal homeostasis, are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines that were first shown to regulate immune cell function have also been demonstrated to regulate bone cells and influence skeletal health. Conversely, products of bone cells appear critical for the engraftment of marrow in bone, the normal development of the hematopoietic and immune systems and provide niche for long-term memory B and T cells. In the past scientists involved in immune and bone cell investigations have rarely interacted in a significant way as these disciplines have developed independently and, for the most part, remain separate. The conference will bring together leading international scientists from both fields to interact so that new collaboration can develop and more rapid progress in understanding the relationships between these fields can be achieved. Short talks will be selected from abstracts from the international community. This conference will have a format to provide an environment of maximum interaction and interchange through lectures, posters, and open discussion.
Author: Peter Pietschmann
Publisher: Springer Science & Business Media
ISBN: 9783709105207
Category : Medical
Languages : en
Pages : 280
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Book Description
Osteoimmunology is a new and rapidly developing field of great importance. It deals with mechanisms and possible treatments of bone-related diseases, such as osteoporosis, rheumatoid arthritis and periodontitis, that are caused by or associated with a malfunctioning immune system. This book describes the basics of bone biology and of the immune system and provides insight into the molecular mechanisms of bone diseases. In addition, clinical data is presented and put into context with the newest research findings. It was intended for all scientists and physicians working in immunology, pathophysiology and osteology.
Author: Zhiyong Hou
Publisher: Frontiers Media SA
ISBN: 2832520979
Category : Medical
Languages : en
Pages : 327
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Book Description
Author: Rupesh K. Srivastava
Publisher: Frontiers Media SA
ISBN: 2889740145
Category : Medical
Languages : en
Pages : 210
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Book Description
Author: Ana Cuenda
Publisher: Frontiers Media SA
ISBN: 2889743470
Category : Science
Languages : en
Pages : 166
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Book Description
Author: Alessandro Rozim Zorzi
Publisher: BoD – Books on Demand
ISBN: 9535125389
Category : Medical
Languages : en
Pages : 388
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Book Description
Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
Author: Lingfeng Zeng
Publisher: Frontiers Media SA
ISBN: 2832545955
Category : Medical
Languages : en
Pages : 170
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Book Description
The human skeleton undergoes a life-long remodeling process. Bone homeostasis requires a potential balance between bone-resorbing osteoclasts and bone-forming osteoblasts. With old age, bone homeostasis undergoes deregulation, and normal bone remodeling could not make bone mass stable, thus causing osteopenia and osteoporosis. Osteoporosis is a systemic bone disease characterized by reduced bone mass, degraded bone microstructure, increased bone fragility and raised risk of fracture. Osteoporosis is a frequently occurring and common disease in the aging population, especially in postmenopausal women and elderly men. The updated research found that one-third of women aged 60 to 70 suffer from osteoporosis; Two-thirds of women aged 80 years or older have osteoporosis. About 20-25% of women over 50 years of age have one or more vertebral fractures. Recent research evidence indicates that an increasing number of plant-based natural products (or secondary metabolites), such as polyunsaturated fatty acids, phytosterols, flavonoids, and other botanicals active compounds, have beneficial effects on the risk of osteoporosis. Compared with conventional therapies, plant-based natural products with thousands of years of medical use experience are gradually approved for clinical use due to fewer adverse reactions, low toxicity, high efficiency and good tolerance. Natural products have been an important source of inspiration for new drug development. However, most of the evidence regarding the anti-osteoporosis effects of natural products comes from in vitro and preclinical in vivo studies, and only a few natural products have been used clinically. All of these above-mentioned still require rigorously designed studies and further verification.
