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Author: David Nasaw
Publisher: Houghton Mifflin Harcourt
ISBN: 0547524722
Category : Biography & Autobiography
Languages : en
Pages : 676
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Book Description
The definitive and “utterly absorbing” biography of America’s first news media baron based on newly released private and business documents (Vanity Fair). William Randolph Hearst, known to his staff as the Chief, was a brilliant business strategist and a man of prodigious appetites. By the 1930s, he controlled the largest publishing empire in the United States, including twenty-eight newspapers, the Cosmopolitan Picture Studio, radio stations, and thirteen magazines. He quickly learned how to use this media stronghold to achieve unprecedented political power. The son of a gold miner, Hearst underwent a public metamorphosis from Harvard dropout to political kingmaker; from outspoken populist to opponent of the New Deal; and from citizen to congressman. In The Chief, David Nasaw presents an intimate portrait of the man famously characterized in the classic film Citizen Kane. With unprecedented access to Hearst’s personal and business papers, Nasaw details Heart’s relationship with his wife Millicent and his romance with Marion Davies; his interactions with Hitler, Mussolini, Churchill, and every American president from Grover Cleveland to Franklin Roosevelt; and his acquaintance with movie giants such as Louis B. Mayer, Jack Warner, and Irving Thalberg. An “absorbing, sympathetic portrait of an American original,” The Chief sheds light on the private life of a very public man (Chicago Tribune).
Author: David Nasaw
Publisher: Houghton Mifflin Harcourt
ISBN: 0547524722
Category : Biography & Autobiography
Languages : en
Pages : 676
Get Book Here
Book Description
The definitive and “utterly absorbing” biography of America’s first news media baron based on newly released private and business documents (Vanity Fair). William Randolph Hearst, known to his staff as the Chief, was a brilliant business strategist and a man of prodigious appetites. By the 1930s, he controlled the largest publishing empire in the United States, including twenty-eight newspapers, the Cosmopolitan Picture Studio, radio stations, and thirteen magazines. He quickly learned how to use this media stronghold to achieve unprecedented political power. The son of a gold miner, Hearst underwent a public metamorphosis from Harvard dropout to political kingmaker; from outspoken populist to opponent of the New Deal; and from citizen to congressman. In The Chief, David Nasaw presents an intimate portrait of the man famously characterized in the classic film Citizen Kane. With unprecedented access to Hearst’s personal and business papers, Nasaw details Heart’s relationship with his wife Millicent and his romance with Marion Davies; his interactions with Hitler, Mussolini, Churchill, and every American president from Grover Cleveland to Franklin Roosevelt; and his acquaintance with movie giants such as Louis B. Mayer, Jack Warner, and Irving Thalberg. An “absorbing, sympathetic portrait of an American original,” The Chief sheds light on the private life of a very public man (Chicago Tribune).
Author: Sandosh Padmanabhan
Publisher: Academic Press
ISBN: 0123868831
Category : Science
Languages : en
Pages : 1119
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Book Description
Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics
Author: United States. Department of the Army
Publisher:
ISBN:
Category : Radioteletype
Languages : en
Pages : 448
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Book Description
Author: Carlos Gomez-Duran
Publisher: Springer Science & Business Media
ISBN: 1468469002
Category : Medical
Languages : en
Pages : 330
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Book Description
The papers presented at the Fifth International Symposium on Heart Valves and published in this volume discuss clinical experience with heart valve replacement in pediatric patients, in adults (age 65 and younger), and in the elderly (age 66 and older). Special considerations in heart valve replacement, such as valve selection, reoperation, results of double valve implantation, quality of life, and the use of valved conduits are also included. Finally, long term clinical follow-up with the ST. JUDE MEDICAL® heart valve, giving 7- and 8-year data is discussed. HEART VALVE REPLACEMENT IN PEDIATRIC PATIENTS Anticoagulation Anticoagulation in children is a difficult and interesting problem. Three princi pal considerations in the use of anticoagulants are patient education, timing, and anticoagulating substance. Additional considerations are patient tolerance and compliance. Generally, the findings indicate, if pediatric patients receive anticoagulation following mechanical valve replacement, it is well accepted and results in few complications. If children are not anticoagulated, complications arise. Conflicting results regarding the efficacy of PERSANTINE® and the use of aspirin vs. COUMADIN® were reported. Doctor Sade's data address some of these questions. * After a 5-year study in * See J Thorac Cardiovasc Surgery 1988; 95:533-561.
Author: Henricus J. Duckers
Publisher: Springer Science & Business Media
ISBN: 1597450014
Category : Medical
Languages : en
Pages : 468
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Book Description
Leading interventional cardiologists, including Patrick Serruys, provide the gold-standard reference on the treatment of restenosis for interventional cardiologists. Dr. Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field, cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy.
Author: David Maidment
Publisher: Pen and Sword Transport
ISBN: 1526752085
Category : Transportation
Languages : en
Pages : 272
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Book Description
After tackling the GW pannier tanks in his ‘Locomotive Portfolios’ for Pen & Sword, author David Maidment seeks out descriptions and photographs of the GW 0-6-2 tank engines, the majority of which were built by the Rhymney, Taff Vale, Barry and other Welsh railways from the last decade or so of the nineteenth century onwards. The engines of eight different companies, absorbed by the GWR in 1922, are described and illustrated, and the way in which many were modernised and rebuilt at Swindon or Caerphilly Works in the 1920s. Charles Collett was, however, faced with a motive power crisis in the mining valleys at the Grouping, as many of the companies had economised on essential maintenance as the GW’s take-over drew near, and he had to hurriedly design a standard 0-6-2T to complement and bolster their work as the powerful GW 2-8-0Ts were too heavy and wide for many of the Cardiff valleys. These engines, the 56XX & 66XX classes, became part of the South Wales scene between 1925 and 1964, mainly running the coal traffic between pits and docks, although they dominated Cardiff Valley passenger services until the influx of BR 3MT 2-6-2Ts and GW 41XX 2-6-2Ts in 1954/5. The book has nearly 40,000 words of text and around 300 black & white photographs.
Author: Sameer Mehta
Publisher: John Wiley & Sons
ISBN: 1119095425
Category : Medical
Languages : en
Pages : 748
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Book Description
Benefit from this concise yet comprehensive manual, designed to improve the practice and process of STEMI interventions Understand the varied pharmacological options available in managing STEMI patients, including newer anti-coagulants Improve your STEMI procedure technique through expert guidance, including stent choice, and other techniques such as trans radial procedures Provides an overview of STEMI networks internationally and how to set up a STEMI program Reviews future perspectives for STEMI and the role of telemedicine for STEMI procedures
Author: Paolo Gresele
Publisher: Cambridge University Press
ISBN: 1139468766
Category : Medical
Languages : en
Pages : 483
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Book Description
A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.
Author: John E. Bennett, MD, MACP
Publisher: Elsevier Health Sciences
ISBN: 1455748013
Category : Medical
Languages : en
Pages : 5094
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Book Description
After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.
Author: Blase A. Carabello
Publisher: Springer
ISBN: 1447128400
Category : Medical
Languages : en
Pages : 319
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Book Description
This book provides up-to-date and user-friendly guidance on the evaluation, diagnosis, and treatment of heart and vascular disease. Chapters cover a broad range of issues related to valve disease, including rheumatic fever, aortic root dilatation, infective endocarditis, and heart disease in pregnancy. The physical examination of major valve lesions, imaging techniques, and choosing a balance therapy are also discussed. Valvular Heart Disease aims to give readers exposure to guideline-directed therapy and therapeutic decisions and is relevant to trainee and practising cardiologists, cardiac surgeons, vascular surgeons, and cardiac radiologists.
