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Author: Guosheng Yin
Publisher: John Wiley & Sons
ISBN: 0470581719
Category : Medical
Languages : en
Pages : 368
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Book Description
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author: Guosheng Yin
Publisher: John Wiley & Sons
ISBN: 0470581719
Category : Medical
Languages : en
Pages : 368
Get Book Here
Book Description
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author: David Clark-Carter
Publisher: Psychology Press
ISBN: 1135431086
Category : Psychology
Languages : en
Pages : 664
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Book Description
Quantitative Psychological Research: A Student's Handbook is a thoroughly revised and updated version of David Clark-Carter's extremely successful Doing Quantitative Psychological Research: From Design to Report. This comprehensive handbook verses the reader in a wide range of statistical tools in order to ensure that quantitative research and the analysis of its findings go beyond mere description towards sound hypothesis formulation and testing. The entire research process is covered in detail, from selection of research design through to analysis and presentation of results. Core topics examined include: * variables and the validity of research designs * summarizing and describing data: numerous practical examples are given of both graphical and numerical methods * reporting research both verbally and in writing * univarate and bi-varate statistics: multivariate analysis and meta-analysis also benefit from dedicated chapters. This catch-all reference book will prove invaluable to both undergraduate and postgraduate students, bringing clarity and reliability to each stage of the quantitative research process.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 112
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Book Description
InfoWorld is targeted to Senior IT professionals. Content is segmented into Channels and Topic Centers. InfoWorld also celebrates people, companies, and projects.
Author: Mark Allen Durivage
Publisher: Quality Press
ISBN: 0873899245
Category : Business & Economics
Languages : en
Pages : 225
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Book Description
This book was written to aid quality technicians and engineers. It is a result of 30 years of quality-related work experience. To that end, the intent of this book is to provide the quality professional working in virtually any industry a quick, convenient, and comprehensive guide to properly conducting design of experiments (DOE) for the purpose of process optimization. This is a practical introduction to the basics of DOE, intended for people who have never been exposed to design of experiments, been intimidated in their attempts to learn about DOE, or have not appreciated the potential of this family of tools in their process improvement and optimization efforts. In addition, this book is a useful reference when preparing for and taking many of the ASQ quality certification examinations, including the Certified Quality Technician (CQT), Certified Six Sigma Green Belt (CSSGB), Certified Quality Engineer (CQE), Certified Six Sigma Black Belt (CSSBB), and Certified Reliability Engineer (CRE).
Author: Ohio Agricultural Experiment Station
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 268
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Book Description
Author: Steven Piantadosi
Publisher: John Wiley & Sons
ISBN: 1118959213
Category : Mathematics
Languages : en
Pages : 918
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Book Description
Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
Author: Jeffery T. Walker
Publisher: Routledge
ISBN: 1317507010
Category : Social Science
Languages : en
Pages : 278
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Book Description
In recent years, the fields of crime analysis and environmental criminology have grown in prominence for their advancements made in understanding crime. This book offers a theoretical and methodological introduction to crime analysis, covering the main techniques used in the analysis of crime and the foundation of crime mapping. Coverage includes discussions of: The development of crime analysis and the profession of the crime analyst, The theoretical roots of crime analysis in environmental criminology, Pertinent statistical methods for crime analysis, Spatio-temporal applications of crime analysis, Crime mapping and the intersection of crime analysis and police work, Future directions for crime analysis. Packed with case studies and including examples of specific problems faced by crime analysts, this book offers the perfect introduction to the analysis and investigation of crime. It is essential reading for students taking courses on crime analysis, crime mapping, crime prevention, and environmental criminology. A companion website offers further resources for students, including flashcards and video and website links. For instructors, it includes chapter-by-chapter PowerPoint slides.
Author: Chava Frankfort-Nachmias
Publisher: SAGE Publications
ISBN: 1544358598
Category : Social Science
Languages : en
Pages : 531
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Book Description
The authors are proud sponsors of the 2020 SAGE Keith Roberts Teaching Innovations Award—enabling graduate students and early career faculty to attend the annual ASA pre-conference teaching and learning workshop. The Ninth Edition of Social Statistics for a Diverse Society continues to emphasize intuition and common sense, while demonstrating the link between the practice of statistics and important social issues. Recognizing that we live in a world characterized by a growing diversity and richness of social differences, best-selling authors Frankfort-Nachmias, Leon-Guerrero, and Davis help students learn key statistical concepts through real research examples related to the dynamic interplay of race, class, gender, and other social variables. The text also helps readers develop important skills such as problem-solving (through a rich variety of exercises), use of statistical software (both SPSS and Excel), and interpreting research literature. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
Author: Rob Brooks-Bilson
Publisher: "O'Reilly Media, Inc."
ISBN: 149190948X
Category : Computers
Languages : en
Pages : 1139
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Book Description
ColdFusion has enjoyed widespread use among developers as a powerful, easy-to-learn platform for creating and deploying dynamic web applications. ColdFusion's simple, tag-based language makes it easy to handle basic tasks, like processing form data and querying databases, but the language is also powerful enough to deliver highly scalable, robust applications. And now that Macromedia has integrated ColdFusion into its MX family of technologies, ColdFusion is capable of interacting with Flash MX applications, which opens up even more possibilities.The first edition of this book has been praised as "the best reference book available on the subject." This new edition, Programming ColdFusion MX, 2nd Edition, goes even further, documenting new techniques for using ColdFusion MX 6.1 to develop and serve dynamic web page content. This exhaustive guide covers everything from the basics to advanced topics, with numerous examples that you can use for your own applications. Contents include: Sharing application data using the web application framework and shared scope variables Accessing databases, maintaining database records, and advanced database techniques such as drill-down queries, query caching, and query of queries Integrating applications with ColdFusion MX's new security framework Interacting with other data sources, including LDAP directories, email servers, and other web servers Extending ColdFusion with user-defined functions (UDFs), custom tags, and ColdFusion Components (CFCs) Advanced topics such as working with XML, consuming and producing web services, and integrating ColdFusion with Flash via Flash Remoting Reference material for all the tags and functions that comprise CFML, the ColdFusion Markup Language Programming ColdFusion MX, 2nd Edition, covers ColdFusion MX 6.1, the latest release of ColdFusion, and is packed with advanced strategies, insider hints, tips, and tricks for creating effective web applications. If you are a ColdFusion developer, you need this book to help you make the most out of ColdFusion MX.
Author: Graham Davis
Publisher: Sterling Publishing Company, Inc.
ISBN: 9781402752476
Category : Juvenile Nonfiction
Languages : en
Pages : 136
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Book Description
This multimedia book and DVD kit covers the entire world! Featuring 160 ready-made maps of every country and major geographical area, it’s a revolutionary new resource for the home (to remember a vacation, for example) and the classroom. The DVD contains the maps themselves, each in the form of a PC and Mac-friendly Photoshop file. Inside the book, there are simple instructions for adapting those maps to your own requirements, and then printing them out, distributing them, or publishing them online. All the maps contain 15 different Photoshop layers, offering a wide choice of cartographic styles, and you can turn country borders, place names, and other elements on or off at will. Every map will print perfectly on a desktop printer, fits on letter-sized paper, and can easily accommodate added graphics, photos, or text.
