Author: Thomas Bayly Howell
Publisher:
ISBN:
Category : Law reports, digests, etc
Languages : en
Pages : 784
Book Description
T. R. I. A. L. S.
Author: Chase Turner
Publisher:
ISBN: 9781734531909
Category :
Languages : en
Pages :
Book Description
Can you imagine waking up tomorrow and having no anxiety at work, finances, marriage or health? Nearly every person deals with anxiety and everyone deals with stress. There are many reasons for this epidemic, but anxiety is a result of how we handle the stress that we and others place in our lives. One of the primary causes of stress is comparative living, which comes as a result of trying to be "normal". The T.R.I.A.L.S. method has been developed to help everyone in their daily routine and relationships so stress can be minimal, and anxiety can be avoided. This workbook is designed to help individuals in their daily walk to develop relationships in a way that will increase communication and decrease stress and anxiety. There is space for making goals and plans for carrying them out.
Publisher:
ISBN: 9781734531909
Category :
Languages : en
Pages :
Book Description
Can you imagine waking up tomorrow and having no anxiety at work, finances, marriage or health? Nearly every person deals with anxiety and everyone deals with stress. There are many reasons for this epidemic, but anxiety is a result of how we handle the stress that we and others place in our lives. One of the primary causes of stress is comparative living, which comes as a result of trying to be "normal". The T.R.I.A.L.S. method has been developed to help everyone in their daily routine and relationships so stress can be minimal, and anxiety can be avoided. This workbook is designed to help individuals in their daily walk to develop relationships in a way that will increase communication and decrease stress and anxiety. There is space for making goals and plans for carrying them out.
Fundamentals of Clinical Trials
Author: Lawrence M. Friedman
Publisher: Springer Science & Business Media
ISBN: 9780387985862
Category : Medical
Languages : en
Pages : 384
Book Description
This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.
Publisher: Springer Science & Business Media
ISBN: 9780387985862
Category : Medical
Languages : en
Pages : 384
Book Description
This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.
The Poison Trials
Author: Alisha Rankin
Publisher: University of Chicago Press
ISBN: 9780226744858
Category : Science
Languages : en
Pages : 0
Book Description
In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
Publisher: University of Chicago Press
ISBN: 9780226744858
Category : Science
Languages : en
Pages : 0
Book Description
In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
A Curse in Darkness (The Thornheart Trials, Book 1)
Author: Sherilee Gray
Publisher: Sherilee Gray
ISBN: 0473580020
Category : Fiction
Languages : en
Pages : 410
Book Description
Willow I once faced evil…and lost. With the fate of my family—and our magic—suddenly in my hands, I vow to protect them no matter what. But the coven trials have claimed many witches, and vanquishing malevolent spirits, while hunting a possessed hellhound on a killing spree, is far more than I bargained for. Now the hellhound’s domineering alpha is shadowing me. More beast than man, Warrick both tempts and terrifies. Still, I can’t resist our overwhelming attraction and when a twisted enemy makes their move and I’m faced with an impossible choice, I need him more than ever. But fortune is fickle, and in a world full of monsters, falling in love can be hazardous to your health—and your heart. The Thornheart Trials: Book 1: A Curse in Darkness Book 2: A Vow of Ruin Book 3: A Trial by Blood Keywords: romance, paranormal romance, witches, witch, witch romance, hellhound, hellhound shifter, Hell, occult, witchcraft, demons, demon hunter, angels, archangels, angels and demons, shifter, alpha male, bad boy hero, strong heroine, fated mates, tattooed hero, romantic suspense, action and adventure, shapeshifter, Urban fantasy, Thriller & Suspense, sagas, series, mystery, paranormal fantasy, dark romance, mystery thriller
Publisher: Sherilee Gray
ISBN: 0473580020
Category : Fiction
Languages : en
Pages : 410
Book Description
Willow I once faced evil…and lost. With the fate of my family—and our magic—suddenly in my hands, I vow to protect them no matter what. But the coven trials have claimed many witches, and vanquishing malevolent spirits, while hunting a possessed hellhound on a killing spree, is far more than I bargained for. Now the hellhound’s domineering alpha is shadowing me. More beast than man, Warrick both tempts and terrifies. Still, I can’t resist our overwhelming attraction and when a twisted enemy makes their move and I’m faced with an impossible choice, I need him more than ever. But fortune is fickle, and in a world full of monsters, falling in love can be hazardous to your health—and your heart. The Thornheart Trials: Book 1: A Curse in Darkness Book 2: A Vow of Ruin Book 3: A Trial by Blood Keywords: romance, paranormal romance, witches, witch, witch romance, hellhound, hellhound shifter, Hell, occult, witchcraft, demons, demon hunter, angels, archangels, angels and demons, shifter, alpha male, bad boy hero, strong heroine, fated mates, tattooed hero, romantic suspense, action and adventure, shapeshifter, Urban fantasy, Thriller & Suspense, sagas, series, mystery, paranormal fantasy, dark romance, mystery thriller
All Our Trials
Author: Emily L. Thuma
Publisher: Haymarket Books
ISBN:
Category : History
Languages : en
Pages : 281
Book Description
A vital history of organizing within and beyond the walls of women’s prisons in the 1970s, illuminating a crucial chapter in today’s abolition feminist struggles. This new edition of an award-winning book features a foreword from acclaimed scholar-activist Sarah Haley and an afterword by Thuma. During the 1970s, grassroots activists within and beyond the walls of women’s prisons forged a radical politics against gender violence and incarceration. Scholar-activist Emily L. Thuma traces the making of this anticarceral feminism at the intersections of struggles for racial and economic justice, imprisoned and institutionalized people’s rights, and gender and sexual liberation. All Our Trials chronicles the organizing, ideas, and influence of those who placed criminalized and marginalized women at the heart of their antiviolence mobilizations. This activism confronted a "tough on crime" political agenda and clashed with the mainstream women’s movement’s strategy of resorting to the criminal legal system as a solution to sexual and domestic violence. Drawing on extensive research, Thuma weaves together the stories of mass defense campaigns, prisoner uprisings, coalition organizing, and activist publications that cut through prison walls. In the process, All Our Trials reveals a vibrant culture of opposition to interpersonal and state violence that both transforms our understanding of 1970s social movements and illuminates the history of present struggles for transformative justice. Winner of the 2020 Lambda Literary Award for LGBTQ Studies Shortlisted for the Organization of American Historians’ Nickliss Prize and the American Studies Association’s Romero Prize
Publisher: Haymarket Books
ISBN:
Category : History
Languages : en
Pages : 281
Book Description
A vital history of organizing within and beyond the walls of women’s prisons in the 1970s, illuminating a crucial chapter in today’s abolition feminist struggles. This new edition of an award-winning book features a foreword from acclaimed scholar-activist Sarah Haley and an afterword by Thuma. During the 1970s, grassroots activists within and beyond the walls of women’s prisons forged a radical politics against gender violence and incarceration. Scholar-activist Emily L. Thuma traces the making of this anticarceral feminism at the intersections of struggles for racial and economic justice, imprisoned and institutionalized people’s rights, and gender and sexual liberation. All Our Trials chronicles the organizing, ideas, and influence of those who placed criminalized and marginalized women at the heart of their antiviolence mobilizations. This activism confronted a "tough on crime" political agenda and clashed with the mainstream women’s movement’s strategy of resorting to the criminal legal system as a solution to sexual and domestic violence. Drawing on extensive research, Thuma weaves together the stories of mass defense campaigns, prisoner uprisings, coalition organizing, and activist publications that cut through prison walls. In the process, All Our Trials reveals a vibrant culture of opposition to interpersonal and state violence that both transforms our understanding of 1970s social movements and illuminates the history of present struggles for transformative justice. Winner of the 2020 Lambda Literary Award for LGBTQ Studies Shortlisted for the Organization of American Historians’ Nickliss Prize and the American Studies Association’s Romero Prize
The Sunbearer Trials
Author: Aiden Thomas
Publisher: Feiwel & Friends
ISBN: 1250822149
Category : Young Adult Fiction
Languages : en
Pages : 403
Book Description
Welcome to The Sunbearer Trials, where teen semidioses compete in a series of challenges with the highest of stakes, in this electric new Mexican-inspired fantasy from Aiden Thomas, the New York Times bestselling author of Cemetery Boys. “Only the most powerful and honorable semidioses get chosen. I’m just a Jade. I’m not a real hero.” As each new decade begins, the Sun’s power must be replenished so that Sol can keep traveling along the sky and keep the chaotic Obsidian gods at bay. Sol selects ten of the most worthy semidioses to compete in the Sunbearer Trials. The winner carries light and life to all the temples of Reino del Sol, but the loser has the greatest honor of all—they will be sacrificed to Sol, their body melted down to refuel the Sun Stones, protecting the world for another ten years. Teo, a seventeen-year-old Jade semidiós and the trans son of the goddess of birds, isn't worried about the Trials . . . at least, not for himself. His best friend, Niya is a Gold semidiós and a shoo-in for the Trials, and while he trusts her abilities, the odds of becoming the sacrifice is one-in-ten. But then, for the first time in over a century, the impossible happens. Sol chooses not one, but two Jade competitors. Teo, and Xio, the thirteen-year-old child of the god of bad luck. Now they must compete in five trials against Gold opponents who are more powerful and better trained. Worst of all, Teo’s annoyingly handsome ex-best friend and famous semidiós Hero, Aurelio is favored to win. Teo is determined to get himself and his friends through the trials unscathed—for fame, glory, and their own survival.
Publisher: Feiwel & Friends
ISBN: 1250822149
Category : Young Adult Fiction
Languages : en
Pages : 403
Book Description
Welcome to The Sunbearer Trials, where teen semidioses compete in a series of challenges with the highest of stakes, in this electric new Mexican-inspired fantasy from Aiden Thomas, the New York Times bestselling author of Cemetery Boys. “Only the most powerful and honorable semidioses get chosen. I’m just a Jade. I’m not a real hero.” As each new decade begins, the Sun’s power must be replenished so that Sol can keep traveling along the sky and keep the chaotic Obsidian gods at bay. Sol selects ten of the most worthy semidioses to compete in the Sunbearer Trials. The winner carries light and life to all the temples of Reino del Sol, but the loser has the greatest honor of all—they will be sacrificed to Sol, their body melted down to refuel the Sun Stones, protecting the world for another ten years. Teo, a seventeen-year-old Jade semidiós and the trans son of the goddess of birds, isn't worried about the Trials . . . at least, not for himself. His best friend, Niya is a Gold semidiós and a shoo-in for the Trials, and while he trusts her abilities, the odds of becoming the sacrifice is one-in-ten. But then, for the first time in over a century, the impossible happens. Sol chooses not one, but two Jade competitors. Teo, and Xio, the thirteen-year-old child of the god of bad luck. Now they must compete in five trials against Gold opponents who are more powerful and better trained. Worst of all, Teo’s annoyingly handsome ex-best friend and famous semidiós Hero, Aurelio is favored to win. Teo is determined to get himself and his friends through the trials unscathed—for fame, glory, and their own survival.
The Salem Witch Trials
Author: Marilynne K. Roach
Publisher: Taylor Trade Publications
ISBN: 9781589791329
Category : History
Languages : en
Pages : 760
Book Description
The Salem Witch Trials is based on over twenty-five years of archival research--including the author's discovery of previously unknown documents--newly found cases and court records. From January 1692 to January 1697 this history unfolds a nearly day-by-day narrative of the crisis as the citizens of New England experienced it.
Publisher: Taylor Trade Publications
ISBN: 9781589791329
Category : History
Languages : en
Pages : 760
Book Description
The Salem Witch Trials is based on over twenty-five years of archival research--including the author's discovery of previously unknown documents--newly found cases and court records. From January 1692 to January 1697 this history unfolds a nearly day-by-day narrative of the crisis as the citizens of New England experienced it.
Book of the End - Great Trials and Tribulations
Author:
Publisher: Darussalam
ISBN: 9789960971506
Category : Islamic eschatology
Languages : en
Pages : 28
Book Description
Like everything, the present universe will also come to an end, and it is a part of our faith to believe in the Last Day. The signs of the Day of Judgment have been foretold by our Prophet (S). Ibn Kathir has collected all the prophesies of the Prophet (S) in his book Al-Bidaayah wan-Nihaayah. In this volume, we have presented from them the signs of the Hour and the events that are yet to take place, although mentioning very few examples of those prophesies that have already been realized.
Publisher: Darussalam
ISBN: 9789960971506
Category : Islamic eschatology
Languages : en
Pages : 28
Book Description
Like everything, the present universe will also come to an end, and it is a part of our faith to believe in the Last Day. The signs of the Day of Judgment have been foretold by our Prophet (S). Ibn Kathir has collected all the prophesies of the Prophet (S) in his book Al-Bidaayah wan-Nihaayah. In this volume, we have presented from them the signs of the Hour and the events that are yet to take place, although mentioning very few examples of those prophesies that have already been realized.
The Prevention and Treatment of Missing Data in Clinical Trials
Author: National Research Council
Publisher: National Academies Press
ISBN: 030918651X
Category : Medical
Languages : en
Pages : 163
Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Publisher: National Academies Press
ISBN: 030918651X
Category : Medical
Languages : en
Pages : 163
Book Description
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Clinical Trials
Author: Tom Brody
Publisher: Academic Press
ISBN: 0128042583
Category : Medical
Languages : en
Pages : 897
Book Description
Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. - Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more - Extensively covers the "study schema" and related features of study design - Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials - Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers
Publisher: Academic Press
ISBN: 0128042583
Category : Medical
Languages : en
Pages : 897
Book Description
Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. - Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more - Extensively covers the "study schema" and related features of study design - Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials - Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers