Trends in Cell Signaling Pathways in Neuronal Fate Decision PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Trends in Cell Signaling Pathways in Neuronal Fate Decision PDF full book. Access full book title Trends in Cell Signaling Pathways in Neuronal Fate Decision by Sabine Wislet. Download full books in PDF and EPUB format.
Author: Sabine Wislet
Publisher: BoD – Books on Demand
ISBN: 9535110594
Category : Medical
Languages : en
Pages : 370
Get Book
Book Description
During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.
Author: Sabine Wislet
Publisher: BoD – Books on Demand
ISBN: 9535110594
Category : Medical
Languages : en
Pages : 370
Get Book
Book Description
During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book
Book Description
Author: Cheryl Chang
Publisher:
ISBN: 9781632422866
Category :
Languages : en
Pages : 0
Get Book
Book Description
This book presents an insight into the understanding of neural stem cell fate decisions. Over the past few decades, several studies on regenerative medicine and stem cells have emphasized on novel therapeutic techniques for treatment of many neurological disorders. It has been observed that the present optimism over potential stem cell therapies has propagated from novel comprehensions of stem cell biology leading to particular cell fate decision. This book aims at providing a basic understanding of signaling pathways underlying the ability of differentiation of various types of stem cells into neurons at the time of development; elucidating progress in cellular therapy that could be employed to recover central nervous system dysfunction in pathological conditions; and helping readers to comprehend the changes in signaling pathways under pathological conditions.
Author: Maya Sieber-Blum
Publisher: World Scientific
ISBN: 9814343803
Category : Medical
Languages : en
Pages : 169
Get Book
Book Description
Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
Author: Nicole Le Douarin
Publisher: Cambridge University Press
ISBN: 9780521620109
Category : Medical
Languages : en
Pages : 494
Get Book
Book Description
This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
Get Book
Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author: Paolo Peretto
Publisher: Frontiers Media SA
ISBN: 2889194949
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 121
Get Book
Book Description
The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
Get Book
Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Alino Martinez-Marcos
Publisher: Frontiers Media SA
ISBN: 2889199630
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 245
Get Book
Book Description
In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.
Author: Paul T. Sharpe
Publisher: Springer Science & Business Media
ISBN: 1592592708
Category : Science
Languages : en
Pages : 752
Get Book
Book Description
Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.
