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Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117
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Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117
Get Book Here
Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author: G. Giebisch
Publisher: Springer Science & Business Media
ISBN: 3642812562
Category : Science
Languages : en
Pages : 493
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Book Description
With contributions by numerous experts
Author: Andrzej Baranski
Publisher: Springer Science & Business Media
ISBN: 1848002513
Category : Medical
Languages : en
Pages : 217
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Book Description
The book encompasses Dr Baranski’s 20 year experience in the field of abdominal organ donation. It is a step-by-step guide with photographs and drawings with clear explanations highlighting pitfalls. The book quickly and easily guides the reader through the difficult steps during organ procurement. It is mainly illustration-based, without much text, and covers surgical technical mistakes and organ damage.
Author: Joshua Mezrich
Publisher: Atlantic Books
ISBN: 178649888X
Category : Medical
Languages : en
Pages : 352
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Book Description
Gripping and evocative, How Death Becomes Life takes us inside the operating room and presents the stark dilemmas that transplant surgeons must face daily: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? The human story behind the most exceptional medicine of our time and it is a poignant reminder that a life lost can also offer the hope of a new beginning. Leading transplant surgeon Dr Joshua Mezrich creates life from loss, moving organs from one body to another. In this intimate, profoundly moving work, he examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the stories of his own patients.
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Kal Renganathan Sharma
Publisher: McGraw Hill Professional
ISBN: 0071663983
Category : Technology & Engineering
Languages : en
Pages : 510
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Book Description
A Cutting-Edge Guide to Applying Transport Phenomena Principles to Bioengineering Systems Transport Phenomena in Biomedical Engineering: Artificial Order Design and Development and Tissue Engineering explains how to apply the equations of continuity, momentum, energy, and mass to human anatomical systems. This authoritative resource presents solutions along with term-by-term medical significance. Worked exercises illustrate the equations derived, and detailed case studies highlight real-world examples of artificial organ design and human tissue engineering. Coverage includes: Fundamentals of fluid mechanics and principles of molecular diffusion Osmotic pressure, solvent permeability, and solute transport Rheology of blood and transport Gas transport Pharmacokinetics Tissue design Bioartificial organ design and immunoisolation Bioheat transport 541 end-of-chapter exercises and review questions 106 illustrations 1,469 equations derived from first principles
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Joseph D. Bronzino
Publisher: CRC Press
ISBN: 1420003879
Category : Medical
Languages : en
Pages : 1322
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Book Description
Over the last century, medicine has come out of the "black bag" and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiolo
Author: G. A. Chauvet
Publisher: Elsevier
ISBN: 148310012X
Category : Science
Languages : en
Pages : 555
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Book Description
Theoretical Systems in Biology: Hierarchical and Functional Integration, Volume II: Tissues and Organs discusses the phenomenology of physiological mechanisms. The book is comprised 10 chapters that are organized into two parts. The first part covers topics about the cell and its environment, such as cell membrane structure, mechanisms of membrane transport, and cell excitability. The second part deals with the mechanisms of physiological functions, which include the metabolic system, the respiratory system, and the renal system. The book will be of great use to researchers and professionals whose work requires a good understanding of human physiology.
Author: Yu-suke Torisawa
Publisher: MDPI
ISBN: 3039289179
Category : Technology & Engineering
Languages : en
Pages : 262
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Book Description
Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.
