Trace Analysis by MS/MS on a Double Focussing Mass Spectrometer PDF Download
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Author: V. T. Borrett
Publisher:
ISBN: 9780642123008
Category : Mass spectrometry
Languages : en
Pages : 8
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Book Description
Recent advances in mass spectrometry - mass spectrometry (ms/ms) indicate that this techniques has a number of advantages over conventional methods for identification and trace analysis of organic materials (1). The method involves detection of fragment or daughter ions which arise from spontaneous or collisionally activated decomposition of parent ions in a field free region of the spectrometer. The main advantages are the additional information provided in the form of generic relationships between ions in the mass spectrum and the high specificity which can be achieved. In many cases, data obtained by ms/ms is sufficient to differentiate between isomeric structures. Although the ion intensity observed by ms/ms methods is considerably lower than with conventional MS, the reduction in 'chemical noise' is generally sufficient to allow detection of compounds at low levels by direct mixture analysis.
Author: V. T. Borrett
Publisher:
ISBN: 9780642123008
Category : Mass spectrometry
Languages : en
Pages : 8
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Book Description
Recent advances in mass spectrometry - mass spectrometry (ms/ms) indicate that this techniques has a number of advantages over conventional methods for identification and trace analysis of organic materials (1). The method involves detection of fragment or daughter ions which arise from spontaneous or collisionally activated decomposition of parent ions in a field free region of the spectrometer. The main advantages are the additional information provided in the form of generic relationships between ions in the mass spectrum and the high specificity which can be achieved. In many cases, data obtained by ms/ms is sufficient to differentiate between isomeric structures. Although the ion intensity observed by ms/ms methods is considerably lower than with conventional MS, the reduction in 'chemical noise' is generally sufficient to allow detection of compounds at low levels by direct mixture analysis.
Author: Nader Rifai
Publisher: Elsevier
ISBN: 0128160640
Category : Science
Languages : en
Pages : 216
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Book Description
Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field
Author: Robert K. Boyd
Publisher: John Wiley & Sons
ISBN: 1119964393
Category : Science
Languages : en
Pages : 1179
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Book Description
This book provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that are utilizing mass spectrometry: Covers all aspects of the use of mass spectrometry for quantitation purposes Written in textbook style to facilitate understanding of this topic Presents fundamentals and real-world examples in a ‘learning-though-doing’ style
Author:
Publisher:
ISBN:
Category : Aeronautics
Languages : en
Pages : 1020
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Book Description
Author: Committee on Assessment of Security Technologies for Transportation
Publisher: National Academies Press
ISBN: 9780309092401
Category : Political Science
Languages : en
Pages : 35
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Book Description
Protection of the traveling public from terrorist threats involving explosives is a major goal of the Transportation Security Administration (TSA). For 20 years, the TSA (and the Federal Aviation Administration before it) have been investing in technologies to meet that goal. To support that activity, the TSA has asked the NRC to assess a variety of technological opportunities for offering such protection. The NRC is approaching this assignment by issuing a series of reports on chosen technology applications. This is the first of that series and presents an assessment of mass spectrometry for enhanced trace detection (ETD) of chemicals contained in explosives. The report describes limitations of trace detection in general and the current technologies in particular. It then presents a discussion of the potential for mass spectrometry to improve EDT including challenges faced by such a system, recommendations for starting a program to take advantage of mass spectrometry, and recommendations for a phased implementation plan.
Author: Jeroen Kool
Publisher: John Wiley & Sons
ISBN: 3527334645
Category : Science
Languages : en
Pages : 402
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Book Description
This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.
Author: Zeev B. Alfassi
Publisher: John Wiley & Sons
ISBN: 3527615768
Category : Science
Languages : en
Pages : 622
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Book Description
The best way to determine trace elements! This easy-to-use handbook guides the reader through the maze of all modern analytical operations. Each method is described by an expert in the field. The book highlights the advantages and disadvantages of individual techniques and enables pharmacologists, environmentalists, material scientists, and food industry to select a judicious procedure for their trace element analysis.
Author:
Publisher:
ISBN:
Category : Mass spectrometry
Languages : en
Pages : 594
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Book Description
Author: Hans-Joachim Hübschmann
Publisher: John Wiley & Sons
ISBN: 3527674330
Category : Science
Languages : en
Pages : 880
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Book Description
The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.
Author:
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 472
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Book Description
