Towards the Synthesis of Monoterpenoids Indole Alkaloids of the Aspidospermatan and Strychnan Type PDF Download
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Author: Dawood Hosni Dawood
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The aim of this work was to access the skeleton of the Aspidosperma and the Strychnos alkaloids using arylcyclohexa-2,5-dienes as common synthetic precursors. Initially, these arylcyclohexadienes were synthesized through Birch reductive alkylation reactions. The desymmetrization of these cyclohexadienes was developed via the Michael addition reaction, providing the Büchi ketone, the tetracyclic core of Aspidosperma alkaloids, in only 6 steps and 17% overall yield. On the other hand, we described the oxidative amination reaction catalyzed by metals (Pd, Cu). The palladium oxidative amination reaction allowed a fast access to the pentacyclic framework of aza-aspidospermanes and the tetracyclic framework of the strychnos. In parallel, we have described an approach toward the pentacyclic skeleton of mossambine and strychnine.
Author: Dawood Hosni Dawood
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The aim of this work was to access the skeleton of the Aspidosperma and the Strychnos alkaloids using arylcyclohexa-2,5-dienes as common synthetic precursors. Initially, these arylcyclohexadienes were synthesized through Birch reductive alkylation reactions. The desymmetrization of these cyclohexadienes was developed via the Michael addition reaction, providing the Büchi ketone, the tetracyclic core of Aspidosperma alkaloids, in only 6 steps and 17% overall yield. On the other hand, we described the oxidative amination reaction catalyzed by metals (Pd, Cu). The palladium oxidative amination reaction allowed a fast access to the pentacyclic framework of aza-aspidospermanes and the tetracyclic framework of the strychnos. In parallel, we have described an approach toward the pentacyclic skeleton of mossambine and strychnine.
Author: J. Edwin Saxton
Publisher: Wiley
ISBN: 9780471951124
Category : Science
Languages : en
Pages : 878
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Book Description
Internationally renowned specialists present a comprehensive survey of the latest advances in this area. The biosynthetic and structural relationships of these compounds are summarized and newly discovered alkaloids described. Discusses versatile biomimetic procedures as well as the pharmacology and clinical applications of monoterpenoid indole alkaloids. Botanical names of all plants cited have been extensively referenced.
Author: Sunil Kumar Talapatra
Publisher: Springer
ISBN: 3642454100
Category : Science
Languages : en
Pages : 1197
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Book Description
Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.
Author: A.N.M. Alamgir
Publisher: Springer
ISBN: 9783030064235
Category : Medical
Languages : en
Pages : 0
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Book Description
This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents. Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
Author: Christophe Wiart
Publisher: Academic Press
ISBN: 0123983711
Category : Health & Fitness
Languages : en
Pages : 430
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Book Description
Kelley/DNA Repair in Cancer Therapy, 2012, 978-0-12-384999-1.
Author: Margaret F. Roberts
Publisher: Springer Science & Business Media
ISBN: 1475729057
Category : Science
Languages : en
Pages : 492
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Book Description
Not since the late 1970s has a single work presented the biology of this heterogenous group of secondary alkaloids in such depth. Alkaloids, a unique treatise featuring leaders in the field, presents both the historical use of alkaloids and the latest discoveries in the biochemistry of alkaloid production in plants alkaloid ecology, including marine invertebrates, animal and plant parasites, and alkaloids as antimicrobial and current medicinal use . Highlights include chapters on the chemical ecology of alkaloids in host-predator interactions, and on the compartmentation of alkaloids synthesis, transport, and storage. Extensive cross-referencing in tabular format makes this volume an excellent reference.
Author: Hans-Joachim Knoelker
Publisher: Springer Science & Business Media
ISBN: 3642255280
Category : Science
Languages : en
Pages : 268
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Book Description
Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Author: M. Naeem
Publisher: Springer
ISBN: 3319516205
Category : Science
Languages : en
Pages : 414
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Book Description
This book studies the production of indole alkaloids in the important medicinal plant Catharanthus roseus (L.) G. Don, commonly known as periwinkle. The anticancer alkaloids, viz. vinblastine and vincristine, are mainly present in the leaves of C. roseus and inhibit the growth of cancer cells by hindering the formation of mitotic apparatus during cell division. Further, vinblastine helps increase the chance of surviving childhood leukemia while vincristine is used to treat Hodgkin’s disease. Great efforts have been made to produce these alkaloids at a large scale by the culture of plant cells. In view of this worldwide demand for commercial use, this book explores how to maximize the production of anticancer alkaloids from C. roseus. This reference book will be helpful for research students, teachers, ethnobotanists, pharmacologists and herbal growers who have a strong interest in this anticancer medicinal plant of paramount importance.
Author: Gyula Palyi
Publisher: Elsevier
ISBN: 0080474039
Category : Science
Languages : en
Pages : 445
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Book Description
Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. - This book contains 32 chapters written by Authors, who are leading authorities in the field - Presents the most recent research taking place in this highly challenging field - Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry
Author:
Publisher: Academic Press
ISBN: 012811780X
Category : Medical
Languages : en
Pages : 332
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Book Description
Neurobiology of Chinese Herb Medicine, Volume 135 is a valuable book for anyone interested in alternative medicine or the scientific research surrounding ancient herbal medicine. This updated volume in the series includes chapters that delve into timely topics, including the Effects of Lycium Barbarum on the Visual System, the Effect of Chinese Herbal Medicine on Alzheimer's Disease, the Effect and Mechanism of Chinese Herbal Medicine on Parkinson's Disease, the Neurobiology of Chinese Herbal Medicine on Major Depressive Disorder, the Treatment of Insomnia with Traditional Chinese Herbal Medicine, and the Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. This series is ideal for Chinese herbal medicine practitioners who are working in a clinical environment, although the clinical applications of Chinese medicinal herbs presented provide useful references and guidance for any clinical practice that specializes in the treatment of various conditions. - Presents a wealth of information on the use of Chinese herbal medicine and its application to many conditions - Provides basic research and clinical studies of Chinese herbal medicines, either as compounds/extracts or formulas - Sheds light on possible action mechanisms of many Chinese herbal medicines
