Total Syntheses of Hasubanan and Acutumine Alkaloids and Development of a Method for the Selective Reduction of Alkenyl Halides PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Total Syntheses of Hasubanan and Acutumine Alkaloids and Development of a Method for the Selective Reduction of Alkenyl Halides PDF full book. Access full book title Total Syntheses of Hasubanan and Acutumine Alkaloids and Development of a Method for the Selective Reduction of Alkenyl Halides by Sandra Marie King. Download full books in PDF and EPUB format.
Author: Sandra Marie King
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Sandra Marie King
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Thong Xuan Nguyen
Publisher:
ISBN:
Category :
Languages : en
Pages : 248
Get Book Here
Book Description
Acutumine, a chlorine containing natural product has recently been rediscovered to inhibit T-cell growth, and aid in memory by enhancing memorisation and anti-amnesic properties in mice and rats. These studies reveal the promising benefits of acutumine in alleviating conditions that are related to loss of memory such as Alzheimer's, Parkinson's and Pick's disease. We have developed a synthetic strategy that allows access to the common [4.4.3.0] propellane core structure, including 2,3-dimethoxycyclohexenone and N-methylpyrrolidine moieties, among the hasubanan alkaloids featuring a facile conversion of a sterically hindered amide to ester via N-acylbenzotriazole and a Dieckmann cyclization of cis-fused bicycle to install the propellane framework. It is envisioned that a strategy towards the common propellane core skeleton found in the hasubanan alkaloids can be applied towards the synthesis of acutumine. Progress towards the total synthesis of acutumine is reported, featuring photo[2+2]cycloaddition reactions to install spiro[5.5]ring stereoselectively.
Author: Nicholas Alexander Calandra
Publisher:
ISBN:
Category :
Languages : en
Pages : 1194
Get Book Here
Book Description
Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Category : Science
Languages : en
Pages : 292
Get Book Here
Book Description
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author: Arkadi Vigalok
Publisher: Springer
ISBN: 3642120733
Category : Science
Languages : en
Pages : 198
Get Book Here
Book Description
Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.
Author: Gordon W. Gribble
Publisher: Springer Science & Business Media
ISBN: 3211993231
Category : Science
Languages : en
Pages : 622
Get Book Here
Book Description
Despite the long association of organohalogen compounds with human activities, nature is the producer of nearly 5,000 halogen-containing chemicals. Once dismissed as accidents of nature or isolation artifacts, organohalogen compounds represent an important and ever growing class of natural products, in many cases exhibiting exceptional biological activity. Since the last comprehensive review in 1996 (Vol. 68, this series), there have been discovered an additional 2,500 organochlorine, organobromine, and other organohalogen compounds. These natural organohalogens are biosynthesized by bacteria, fungi, lichen, plants, marine organisms of all types, insects, and higher animals including humans. These compounds are also formed abiogenically, as in volcanoes, forest fires, and other geothermal events.In some instances, natural organohalogens are precisely the same chemicals that man synthesizes for industrial use, and some of the quantities of these natural chemicals far exceed the quantities emitted by man.
Author: Markus Heinrich
Publisher: Springer Science & Business Media
ISBN: 3642281230
Category : Science
Languages : en
Pages : 465
Get Book Here
Book Description
Boron-Doped Diamond Electrodes for Electroorganic Chemistry, by Siegfried R. Waldvogel, Stamo Mentizi und Axel Kirste.- Modern Developments in Aryl Radical Chemistry, by Gerald Pratsch und Markus R. Heinrich.- Radical Additions to Chiral Hydrazones: Stereoselectivity and Functional Group Compatibility, by Gregory K. Friestad.- Hydrogen Atom Donors: Recent Developments, by Andreas Gansäuer, Lei Shi, Matthias Otte, Inga Huth, Antonio Rosales, Iris Sancho-Sanz, Natalia M. Padial und J. Enrique Oltra.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions? - A Fruitful Interplay Anyway Part 1. Radical Catalysis by Group 4 to Group 7 Elements, by Ullrich Jahn.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions? - A Fruitful Interplay Anyway Part 2. Radical Catalysis by Group 8 and 9 Elements, by Ullrich Jahn.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions?: A Fruitful Interplay Anyway Part 3: Catalysis by Group 10 and 11 Elements and Bimetallic Catalysis, by Ullrich Jahn.-
Author: E.J. Corey
Publisher: Рипол Классик
ISBN: 5885010811
Category : Science
Languages : en
Pages : 447
Get Book Here
Book Description
Author: A. Douglas Kinghorn
Publisher: Springer Nature
ISBN: 3030898733
Category : Science
Languages : en
Pages : 116
Get Book Here
Book Description
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
Author: Hans-Joachim Knoelker
Publisher: Springer Science & Business Media
ISBN: 3642255280
Category : Science
Languages : en
Pages : 268
Get Book Here
Book Description
Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
