Toll-like Receptors: Roles in Infection and Neuropathology PDF Download
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Author: Tammy Kielian
Publisher: Springer Science & Business Media
ISBN: 3642005497
Category : Medical
Languages : en
Pages : 198
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Book Description
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.
Author: Tammy Kielian
Publisher: Springer Science & Business Media
ISBN: 3642005497
Category : Medical
Languages : en
Pages : 198
Get Book Here
Book Description
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.
Author: Tammy Kielian
Publisher: Springer
ISBN: 9783642005503
Category : Medical
Languages : en
Pages : 191
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Book Description
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration.
Author: Stefan Bauer
Publisher: Springer Science & Business Media
ISBN: 3540721673
Category : Medical
Languages : en
Pages : 243
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Book Description
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Author: Carol Shoshkes Reiss
Publisher: Springer
ISBN: 3319331892
Category : Medical
Languages : en
Pages : 562
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Book Description
This second edition is a comprehensive study of the viruses that affect the brain and the central nervous system. Along with a focus on the viruses themselves, it addresses the diseases they cause, current treatments and preventive measures. Also discussed are the unique aspects of how viruses cause disease and why certain hosts are more susceptible (e.g., polymorphisms, age, co-morbidities). Because there are 29 cutting edge chapters, written by experts in the fields, Neurotropic Viral Infections has been divided into two separate volumes. Volume 1, Neurotropic RNA Viruses, includes 14 chapters on RNA viruses that cause human disease of the central nervous system ranging from Bornavirus to polio to West Nile. Volume 2, Neurotropic Retroviruses, DNA Viruses, Immunity and Transmission, includes 15 chapters divided into two parts. Part 1 includes 7 chapters on retroviruses and DNA viruses that cause human disease of the central nervous system ranging from HIV to varicella zoster virus. Part 2 includes chapters on transmission of these viruses by transplantation, bites by bats and insects, clinical management of the infections, and beneficial uses of attenuated viruses. Neurotropic Viral Infections is a unique resource, bridging basic, clinical, and translational approaches.
Author: Gregory Atkins
Publisher: Cambridge University Press
ISBN: 1139851063
Category : Medical
Languages : en
Pages : 141
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Book Description
Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.
Author: Elisabetta Babetto
Publisher: Humana
ISBN: 9781071605844
Category : Science
Languages : en
Pages : 0
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Book Description
This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Brian D. Gulbransen
Publisher: Biota Publishing
ISBN: 1615046615
Category : Medical
Languages : en
Pages : 72
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Book Description
The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography
Author: Alan C. Jackson
Publisher: Academic Press
ISBN: 0080550096
Category : Science
Languages : en
Pages : 681
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Book Description
Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes. - Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow - More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year - New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled - Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed - Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation - Includes an increase in illustrations to more accurately represent this diseases' unique horror
Author: Ulrich Dobrindt
Publisher: Springer Science & Business Media
ISBN: 3642365604
Category : Medical
Languages : en
Pages : 360
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Book Description
This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals. The ongoing development of (meta-)genomic, transcriptomic, proteomic and bioinformatic analyses of pathogenic and commensal microorganisms and their host interaction provides a comprehensive introduction to the microbiological analysis of host-microbe interplay and its consequences for infection or commensalism.
Author: Cornelis Murre
Publisher: Springer Science & Business Media
ISBN: 3642241034
Category : Medical
Languages : en
Pages : 197
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Book Description
The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
