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Author: Martin J. Smith
Publisher: Diversion Books
ISBN: 1626812152
Category : Fiction
Languages : en
Pages : 417
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Book Description
An obsessed cop gets a second chance to take down a madman he failed to arrest a decade earlier in this thriller by the author of Combustion. Pittsburgh, 1986: The city is gripped in a panic as a maniac slips poison onto pharmacy shelves. All the evidence has pointed to Ron Corbett, but shoddy policework let Corbett off the hook and left the crime unsolved. Ten years later, it’s happening again. This time, for the most personal of reasons, Detective Downing has made it his mission to see Corbett behind bars. He enlists the help of Jim Christensen, a psychologist who specializes in memory, to interview Corbett’s son, now a young man with a painful past and problems of his own. Does the boy remember his father poisoning pill containers? Has he blocked memories of a horrific crime spree enacted in his own house? As Christensen explores the boy’s memory and Downing grows more obsessive investigating the case, both men fear that the killings now may not be as random as they once thought, and that unlocking memories may draw them too close to a vicious predator. “Time Release sizzles, cooks, and singes! It’s a whipcord thriller full of deftly drawn characters, intrigue, and taut action. This is a spellbindingly accomplished first novel”—James Ellroy, New York Times–bestselling author of The Big Nowhere “A fast, smart read and one fine thriller.”—Robert Ferrigno, New York Times–bestselling author of Prayers for the Assassin “Unexpected plot twists and breathless tension combine for a suspenseful ride that doesn’t let up.”—The Kansas City Star “Time Release is a fast, smart read and one fine thriller.” —Robert Ferrigno, New York Times bestselling author of Prayers for the Assassin “Unexpected plot twists and breathless tension combine for a suspenseful ride that doesn’t let up.” —The Kansas City Star
Author: Martin J. Smith
Publisher: Diversion Books
ISBN: 1626812152
Category : Fiction
Languages : en
Pages : 417
Get Book Here
Book Description
An obsessed cop gets a second chance to take down a madman he failed to arrest a decade earlier in this thriller by the author of Combustion. Pittsburgh, 1986: The city is gripped in a panic as a maniac slips poison onto pharmacy shelves. All the evidence has pointed to Ron Corbett, but shoddy policework let Corbett off the hook and left the crime unsolved. Ten years later, it’s happening again. This time, for the most personal of reasons, Detective Downing has made it his mission to see Corbett behind bars. He enlists the help of Jim Christensen, a psychologist who specializes in memory, to interview Corbett’s son, now a young man with a painful past and problems of his own. Does the boy remember his father poisoning pill containers? Has he blocked memories of a horrific crime spree enacted in his own house? As Christensen explores the boy’s memory and Downing grows more obsessive investigating the case, both men fear that the killings now may not be as random as they once thought, and that unlocking memories may draw them too close to a vicious predator. “Time Release sizzles, cooks, and singes! It’s a whipcord thriller full of deftly drawn characters, intrigue, and taut action. This is a spellbindingly accomplished first novel”—James Ellroy, New York Times–bestselling author of The Big Nowhere “A fast, smart read and one fine thriller.”—Robert Ferrigno, New York Times–bestselling author of Prayers for the Assassin “Unexpected plot twists and breathless tension combine for a suspenseful ride that doesn’t let up.”—The Kansas City Star “Time Release is a fast, smart read and one fine thriller.” —Robert Ferrigno, New York Times bestselling author of Prayers for the Assassin “Unexpected plot twists and breathless tension combine for a suspenseful ride that doesn’t let up.” —The Kansas City Star
Author: Robert Priest
Publisher: Ekstasis Editions
ISBN: 9781896860176
Category : Poetry
Languages : en
Pages : 76
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Book Description
Time Release Poems should be swallowed one or two at a time and absorbed slowly in order to facilitate release of little wisdoms in the mind. They may be taken anytime and are useful in personal expressions of pith, rage and even love
Author: J.N. Campbell
Publisher: Springer
ISBN: 3319917889
Category : Science
Languages : en
Pages : 150
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Book Description
This Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually part of a growing concern about overuse. This seemed an inviting prospect for those in pain, but as the ubiquitous media coverage continues to lay bare, the levels of abuse point to the fact that perhaps an epidemic is upon us, if not a culture war. Seeking answers to how and why this addiction crisis transpired over two hundred years of long development, this Brief examines the role that the chemistry laboratory played in turning patients into consumers. By utilizing a host of diverse sources, this Brief seeks to trace the design and the production of opioids and their antecedents over the past two centuries. From the isolation and development of the first alkaloids with morphine that relieved pain within the home and on the battlefield, to the widespread use of nostrums and the addiction crisis that ensued, to the dissemination of drugs by what became known as Big Pharma after the World Wars; and finally, to competition from home-made pharmaceuticals, the progenitor was always, in some form, a type of chemistry lab. At times, the laboratory pressed science to think deeply about society's maladies, such as curing disease and alleviating pain, in order to look for new opportunities in the name of progress. Despite the best intentions opioids have created a paradox of pain as they were manipulated by creating relief with synthetic precision and influencing a dystopian vision. Thus, influence came in many forms, from governments, from the medical community, and from the entrepreneurial aspirations of the general populace. For better, but mostly for worse, all played a role in changing forever the trajectory of what started with the isolation of a compound in Germany. Combining chemistry and history in a rousing new long-form narrative that even broadens the definition of a laboratory, the origins and future of this complicated topic are carefully examined.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309486483
Category : Medical
Languages : en
Pages : 175
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Book Description
The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Author: Hugo J. Bellen
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 466
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Book Description
This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Author: Niall Richard Murphy
Publisher: "O'Reilly Media, Inc."
ISBN: 1491951176
Category :
Languages : en
Pages : 552
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Book Description
The overwhelming majority of a software system’s lifespan is spent in use, not in design or implementation. So, why does conventional wisdom insist that software engineers focus primarily on the design and development of large-scale computing systems? In this collection of essays and articles, key members of Google’s Site Reliability Team explain how and why their commitment to the entire lifecycle has enabled the company to successfully build, deploy, monitor, and maintain some of the largest software systems in the world. You’ll learn the principles and practices that enable Google engineers to make systems more scalable, reliable, and efficient—lessons directly applicable to your organization. This book is divided into four sections: Introduction—Learn what site reliability engineering is and why it differs from conventional IT industry practices Principles—Examine the patterns, behaviors, and areas of concern that influence the work of a site reliability engineer (SRE) Practices—Understand the theory and practice of an SRE’s day-to-day work: building and operating large distributed computing systems Management—Explore Google's best practices for training, communication, and meetings that your organization can use
Author: Mark Haddon
Publisher: Anchor Canada
ISBN: 0307371565
Category : Fiction
Languages : en
Pages : 182
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Book Description
A bestselling modern classic—both poignant and funny—narrated by a fifteen year old autistic savant obsessed with Sherlock Holmes, this dazzling novel weaves together an old-fashioned mystery, a contemporary coming-of-age story, and a fascinating excursion into a mind incapable of processing emotions. Christopher John Francis Boone knows all the countries of the world and their capitals and every prime number up to 7,057. Although gifted with a superbly logical brain, Christopher is autistic. Everyday interactions and admonishments have little meaning for him. At fifteen, Christopher’s carefully constructed world falls apart when he finds his neighbour’s dog Wellington impaled on a garden fork, and he is initially blamed for the killing. Christopher decides that he will track down the real killer, and turns to his favourite fictional character, the impeccably logical Sherlock Holmes, for inspiration. But the investigation leads him down some unexpected paths and ultimately brings him face to face with the dissolution of his parents’ marriage. As Christopher tries to deal with the crisis within his own family, the narrative draws readers into the workings of Christopher’s mind. And herein lies the key to the brilliance of Mark Haddon’s choice of narrator: The most wrenching of emotional moments are chronicled by a boy who cannot fathom emotions. The effect is dazzling, making for one of the freshest debut in years: a comedy, a tearjerker, a mystery story, a novel of exceptional literary merit that is great fun to read.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309082587
Category : Medical
Languages : en
Pages : 172
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Book Description
This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
Author: Francesco Cirillo
Publisher: Crown Currency
ISBN: 1524760714
Category : Business & Economics
Languages : en
Pages : 162
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Book Description
Discover the internationally acclaimed time management system that’s gone viral on TikTok and has already changed millions of lives! Francesco Cirillo developed his famed system for improving productivity as a college student thirty years ago. Using a kitchen timer shaped like a pomodoro (Italian for tomato), Cirillo divided the time he spent working on a project into 25-minute intervals, with 5-minute breaks in between, in order to get more done, without interruptions. By grouping a number of pomodoros together, users can tackle a project of any length, and drastically improve their productivity, enhance their focus, and better achieve their goals. Originally self-published, and shared virally online, this new publication of The Pomodoro Technique includes several new chapters on how teams can use the pomodoro method to save time and increase productivity. The process underlying Cirillo’s technique includes five stages: planning the day’s tasks, tracking your efforts, recording your daily activities, processing what you have done, and visualizing areas for improvement. With this tried and tested method, readers can simplify their work, find out how much time and effort a task really requires, and improve their focus so they can get more done in the same amount of time each day.
Author: Andrea Bayer
Publisher: Metropolitan Museum of Art
ISBN: 1588397092
Category : Art
Languages : en
Pages : 291
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Book Description
Published to celebrate The Metropolitan Museum of Art’s 150th anniversary, Making The Met, 1870–2020 examines the institution’s evolution from an idea—that art can inspire anyone who has access to it—to one of the most beloved global collections in the world. Focusing on key transformational moments, this richly illustrated book provides insight into the visionary figures and events that led The Met in new directions. Among the many topics explored are the impact of momentous acquisitions, the central importance of education and accessibility, the collaboration that resulted from international excavations, the Museum’s role in preserving cultural heritage, and its interaction with contemporary art and artists. Complementing this fascinating history are more than two hundred works that changed the very way we look at art, as well as rarely seen archival and behind-the-scenes images. In the final chapter, Met Director Max Hollein offers a meditation on evolving approaches to collecting art from around the world, strategies for reaching new and diverse audiences, and the role of museums today.
