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Author: Simon Goede
Publisher: CRC Press
ISBN: 1000795942
Category : Technology & Engineering
Languages : en
Pages : 337
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Book Description
In recent years, a considerable amount of effort has been devoted, both in industry and academia, towards the behavioral modeling, evaluation and prediction of the hypothalamus pituitary thyroid system.Thyroid Systems Engineering targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. Leveraging on the insights emerging from the unique combination of an electrical engineer working with a clinical thyroidologist, and both being scientists skilled in mathematics, the authors introduce this new discipline and field of scientific investigation aptly designated as Thyroid Systems Engineering.Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within.This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. They represent a new discipline based on mathematical modeling in physiology applicable to medical diagnostics, measurement and treatment to cooperate in the clinical team and realize an optimized treatment for patients.
Author: Simon Goede
Publisher: CRC Press
ISBN: 1000795942
Category : Technology & Engineering
Languages : en
Pages : 337
Get Book
Book Description
In recent years, a considerable amount of effort has been devoted, both in industry and academia, towards the behavioral modeling, evaluation and prediction of the hypothalamus pituitary thyroid system.Thyroid Systems Engineering targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. Leveraging on the insights emerging from the unique combination of an electrical engineer working with a clinical thyroidologist, and both being scientists skilled in mathematics, the authors introduce this new discipline and field of scientific investigation aptly designated as Thyroid Systems Engineering.Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within.This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. They represent a new discipline based on mathematical modeling in physiology applicable to medical diagnostics, measurement and treatment to cooperate in the clinical team and realize an optimized treatment for patients.
Author: J. H. U. Brown
Publisher: Academic Press
ISBN: 1483216640
Category : Medical
Languages : en
Pages : 319
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Book Description
Engineering Principles in Physiology, Volume I covers the various aspects of biomedical engineering. This volume is organized into three parts encompassing 12 chapters that consider a holistic approach to physiology and the principles of communication and control, including energy input and output. The first part deals with the physiological information and related concepts, as well as the overall integration in the living body. The second part highlights the communication integration of the central nervous system as a whole with the body's various sense organs. The third part focuses on the diversity of function and modeling of various glandular functions of the endocrine system. This part briefly deals with the cardiovascular system as a system of communication and control. This book will prove useful to physiologists, biomedical engineers, and workers in the related fields.
Author: Adrian V. Gheorghe
Publisher: John Wiley & Sons
ISBN:
Category : Technology & Engineering
Languages : en
Pages : 352
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Book Description
Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Author: Geraldo Medeiros-Neto
Publisher: CRC Press
ISBN: 1000006085
Category : Medical
Languages : en
Pages : 232
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Book Description
First Published in 1994, Inherited Disorders of the Thyroid System presents a thorough and comprehensive study of the biology of varied thyroid disorders illustrated by numerous tables and figures. This monograph begins with the initial step in thyroid hormone production and concludes with the interaction of the thyroid hormones with their target cells. The authors have been involved in research in this field for many years and help to bring together, in a single text, the widely scattered literature relevant to the disorders of the thyroid system.
Author: Johannes W. Dietrich
Publisher: Frontiers Media SA
ISBN: 288945570X
Category :
Languages : en
Pages : 107
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Book Description
The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1404
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Mayank Singh
Publisher: Springer
ISBN: 9811399395
Category : Computers
Languages : en
Pages : 512
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Book Description
This two-volume set (CCIS 1045 and CCIS 1046) constitutes the refereed proceedings of the Third International Conference on Advances in Computing and Data Sciences, ICACDS 2019, held in Ghaziabad, India, in April 2019. The 112 full papers were carefully reviewed and selected from 621 submissions. The papers are centered around topics like advanced computing, data sciences, distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations.
Author: W.W. de Herder
Publisher: Springer Science & Business Media
ISBN: 146154341X
Category : Medical
Languages : en
Pages : 272
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Book Description
`Morphological imaging' and `functional imaging' are current mainstays for the diagnosis, successful treatment and accurate follow-up of patients with endocrine disorders. Functional and Morphological Imaging of the Endocrine System provides the reader with comprehensive but concise insights in the application of cutting edge imaging techniques and updated imaging protocols for the diagnosis and treatment of hypersecretory hormonal syndromes and functional endocrine masses.
Author: Subhash Kumar Wangnoo
Publisher: JP Medical Ltd
ISBN: 9386056259
Category : Medical
Languages : en
Pages : 356
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Book Description
Comprehensive resource providing latest information on diagnosis and management of thyroid disorders. Covers medical and surgical treatment of both benign and malignant conditions.
Author: Lewis E. Braverman
Publisher: Lippincott Williams & Wilkins
ISBN: 145112063X
Category : Medical
Languages : en
Pages : 925
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Book Description
Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunction’s effects on other organ systems. Also addressed are clinical controversies regarding the ageing thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy. New to this edition: · Twenty-three chapters authored by new contributors and international experts · A companion website with fully searchable text for quick reference · Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field
