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Author: Alan Perelson
Publisher: Westview Press
ISBN:
Category : Juvenile Nonfiction
Languages : en
Pages : 438
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Book Description
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomen
Author: Alan Perelson
Publisher: Westview Press
ISBN:
Category : Juvenile Nonfiction
Languages : en
Pages : 438
Get Book Here
Book Description
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomen
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 0429972334
Category : Science
Languages : en
Pages : 310
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Book Description
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Author: Alan S. Perelson
Publisher: Springer Science & Business Media
ISBN: 3642769772
Category : Medical
Languages : en
Pages : 485
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Book Description
Immunology is largely a science of observation and experimentation, and these approaches have lead to great increases in our knowledge of the genes, molecules and cells of the immune system. This book is an up-to-date discussion of the current state of modelling and theoretical work in immunology, of the impact of theory on experiment, and of future directions for theoretical research. Among the topics discussed are the function and evolution of the immune system, computer modelling of the humoral immune response and of idiotypic networks and idiotypic mimicry, T-cell memory, cryptic peptides, new views and models of AIDS and autoimmunity, and the shaping of the immune repertoire by early presented antigens and self immunoglobulin.
Author: Hannah D. Zane
Publisher: Saunders
ISBN:
Category : Medical
Languages : en
Pages : 388
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Book Description
IMMUNOLOGY: Theoretical and Practical Concepts in Laboratory Medicine provides a comprehensive, yet concise, summary of fundamental and advanced immunologic concepts and procedures. This modern, up-to-date text contains new information regarding molecular techniques in the field. The text supplements the required procedures manuals by emphasizing the theoretical aspect of the methods, quality assurance, and the validity of test results, as well as the application of laboratory finding to the diagnosis and monitoring of representative disease states.
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 0429961243
Category : Science
Languages : en
Pages : 430
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Book Description
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology." The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 0429961251
Category : Science
Languages : en
Pages : 427
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Book Description
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Author: George I. Bell
Publisher:
ISBN: 9780783733692
Category :
Languages : en
Pages : 646
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Book Description
Author: C. Bruni
Publisher: Springer Science & Business Media
ISBN: 3642931308
Category : Mathematics
Languages : en
Pages : 286
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Book Description
This volume collects the contributions presented at the "Working Conference on System Theory in Immunology", held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied mathematics on the other, in order to identify problems of common interest and to establish a network of joint effort toward their solution. The methodologies of system theory for processing experimental data and for describing dynamical phenomena could indeed contribute significantly to the under standing of basic immunological facts. Conversely, the complexity of experimental results and of interpretative models should stimulate mathematicians to formulate new problems and to design appropriate procedures of analysis. The multitude of scientific publications in theoretical biology, appeared in recent years, confirms this trend and calls for extensive interaction between mat- matics and immunology. The material of this volume is divided into five sections, along the scheme of the Conference program.
Author: Henri Atlan
Publisher: Springer Science & Business Media
ISBN: 3642839355
Category : Medical
Languages : en
Pages : 123
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Book Description
For a long time, immunology has been dominated by the idea of a simple linear cause-effect relationship between the exposure to an antigen and the production of specific antibodies against that antigen. Clonal selection was the name of the theory based on this idea and it has provided the main concepts to account for the known features of the immune response. More recently, immunologists have discovered a wealth of new facts, in the form of different regulatory cells (helpers, suppressors, antigen presenting cells), genetic determinations of immune responses such as those involved in graft re jections, different molecular structures responsible for intercellular interactions such as interleukins, cytokins, idiotype-antiidiotype recognition and others. While furthering our understanding of the local interactions (molecular and cellular) in volved in the immune response, these discoveries have led to a questioning of the simplicities of the classical clonal selection theory. It is clear today that every single immune response is a cooperative phenomenon involving several different molecular and cellular interactions taking place in a coupled manner. In addition, cross reactivity to different antigens has shown that responses of the whole im mune system to different antigens are not completely isolated from one another and that the history of encounters with different antigens plays a crucial role in the maturation of the whole system. Thus, problems of complexity, generation of di versity and self-organization have entered the field of immunology.
Author: Kendall A. Smith
Publisher: World Scientific
ISBN: 9814271756
Category : Medical
Languages : en
Pages : 249
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Book Description
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented. This molecular understanding of the immune system is especially important for the design of successful vaccines, and also explains why vaccines fail.
