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Author: Manish I. Patel
Publisher: Springer Science & Business Media
ISBN: 3642156029
Category : Technology & Engineering
Languages : en
Pages : 173
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Book Description
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Author: Manish I. Patel
Publisher: Springer Science & Business Media
ISBN: 3642156029
Category : Technology & Engineering
Languages : en
Pages : 173
Get Book Here
Book Description
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Author: Guillermo Valencia-Palomo
Publisher: MDPI
ISBN: 3038974471
Category : Mathematics
Languages : en
Pages : 257
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Book Description
This book is a printed edition of the Special Issue "Optimization in Control Applications" that was published in MCA
Author: Mohd Hafiz Mohd
Publisher: Springer
ISBN: 9789811626319
Category : Mathematics
Languages : en
Pages : 441
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Book Description
This book discusses the latest progresses and developments on complex systems research and intends to give an exposure to prospective readers about the theoretical and practical aspects of mathematical modelling, numerical simulation and agent-based modelling frameworks. The main purpose of this book is to emphasize a unified approach to complex systems analysis, which goes beyond to examine complicated phenomena of numerous real-life systems; this is done by investigating a huge number of components that interact with each other at different (microscopic and macroscopic) scales; new insights and emergent collective behaviours can evolve from the interactions between individual components and also with their environments. These tools and concepts permit us to better understand the patterns of various real-life systems and help us to comprehend the mechanisms behind which distinct factors shaping some complex systems phenomena being influenced. This book is published in conjunction with the International Workshop on Complex Systems Modelling & Simulation 2019 (CoSMoS 2019): IoT & Big Data Integration. This international event was held at the Universiti Sains Malaysia Main Campus, Penang, Malaysia, from 8 to 11 April 2019. This book appeals to readers interested in complex systems research and other related areas such as mathematical modelling, numerical simulation and agent-based modelling frameworks.
Author: Jiafu Wan
Publisher: Springer
ISBN: 331944350X
Category : Computers
Languages : en
Pages : 276
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Book Description
This book constitutes the thoroughly refereed post-conference proceedings of the International Conference on Industrial IoT Technologies and Applications, IoT 2016, held in GuangZhou, China, in March 2016. The volume contains 26 papers carefully reviewed and selected from 55 submissions focusing on topics such as big data, cloud computing, Internet of Things (IoT).
Author: Hoai An Le Thi
Publisher: Springer
ISBN: 3030218031
Category : Technology & Engineering
Languages : en
Pages : 1164
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Book Description
This book contains 112 papers selected from about 250 submissions to the 6th World Congress on Global Optimization (WCGO 2019) which takes place on July 8–10, 2019 at University of Lorraine, Metz, France. The book covers both theoretical and algorithmic aspects of Nonconvex Optimization, as well as its applications to modeling and solving decision problems in various domains. It is composed of 10 parts, each of them deals with either the theory and/or methods in a branch of optimization such as Continuous optimization, DC Programming and DCA, Discrete optimization & Network optimization, Multiobjective programming, Optimization under uncertainty, or models and optimization methods in a specific application area including Data science, Economics & Finance, Energy & Water management, Engineering systems, Transportation, Logistics, Resource allocation & Production management. The researchers and practitioners working in Nonconvex Optimization and several application areas can find here many inspiring ideas and useful tools & techniques for their works.
Author: Yacov Y. Haimes
Publisher: John Wiley & Sons
ISBN: 1119173698
Category : Technology & Engineering
Languages : en
Pages : 950
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Book Description
A comprehensive guide to the theory, methodology, and development for modeling systems of systems Modeling and Managing Interdependent Complex Systems of Systems examines the complexity of, and the risk to, emergent interconnected and interdependent complex systems of systems in the natural and the constructed environment, and in its critical infrastructures. For systems modelers, this book focuses on what constitutes complexity and how to understand, model and manage it.Previous modeling methods for complex systems of systems were aimed at developing theory and methodologies for uncoupling the interdependencies and interconnections that characterize them. In this book, the author extends the above by utilizing public- and private- sector case studies; identifies, explores, and exploits the core of interdependencies; and seeks to understand their essence via the states of the system, and their dominant contributions to the complexity of systems of systems. The book proposes a reevaluation of fundamental and practical systems engineering and risk analysis concepts on complex systems of systems developed over the past 40 years. This important resource: Updates and streamlines systems engineering theory, methodology, and practice as applied to complex systems of systems Introduces modeling methodology inspired by philosophical and conceptual thinking from the arts and sciences Models the complexity of emergent interdependent and interconnected complex systems of systems by analyzing their shared states, decisions, resources, and decisionmakers Written for systems engineers, industrial engineers, managers, planners, academics and other professionals in engineering systems and the environment,this text is the resource for understanding the fundamental principles of modeling and managing complex systems of systems, and the risk thereto.
Author: Thilo Gross
Publisher: Springer
ISBN: 9783642260148
Category : Science
Languages : en
Pages : 332
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Book Description
Adding one and one makes two, usually. But sometimes things add up to more than the sum of their parts. This observation, now frequently expressed in the maxim “more is different”, is one of the characteristic features of complex systems and, in particular, complex networks. Along with their ubiquity in real world systems, the ability of networks to exhibit emergent dynamics, once they reach a certain size, has rendered them highly attractive targets for research. The resulting network hype has made the word “network” one of the most in uential buzzwords seen in almost every corner of science, from physics and biology to economy and social sciences. The theme of “more is different” appears in a different way in the present v- ume, from the viewpoint of what we call “adaptive networks.” Adaptive networks uniquely combine dynamics on a network with dynamical adaptive changes of the underlying network topology, and thus they link classes of mechanisms that were previously studied in isolation. Here adding one and one certainly does not make two, but gives rise to a number of new phenomena, including highly robust se- organization of topology and dynamics and other remarkably rich dynamical beh- iors.
Author: Peter S. Hovmand
Publisher: Springer Science & Business Media
ISBN: 1461487633
Category : Psychology
Languages : en
Pages : 117
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Book Description
Community Based System Dynamics introduces researchers and practitioners to the design and application of participatory systems modeling with diverse communities. The book bridges community- based participatory research methods and rigorous computational modeling approaches to understanding communities as complex systems. It emphasizes the importance of community involvement both to understand the underlying system and to aid in implementation. Comprehensive in its scope, the volume includes topics that span the entire process of participatory systems modeling, from the initial engagement and conceptualization of community issues to model building, analysis, and project evaluation. Community Based System Dynamics is a highly valuable resource for anyone interested in helping to advance social justice using system dynamics, community involvement, and group model building, and helping to make communities a better place.
Author: Manish I. Patel
Publisher: Springer
ISBN: 9783642156045
Category : Technology & Engineering
Languages : en
Pages : 168
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Book Description
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Author: Niall Shanks
Publisher: Universal-Publishers
ISBN: 1599425025
Category : Medical
Languages : en
Pages : 445
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Book Description
The central concern of this book is with the "prediction problem" in biomedical research. In particular, the authors examine the use of animal models to predict human responses in drug and disease research. The arguments discussed are drawn from both biological and biomedical theory (with numerous examples and case studies drawn from evolutionary biology, complex systems theory, oncology, teratology, and AIDS research), and analyses of empirical evidence (concerning, for example, data on intra- and inter-species differences revealed by recent results from genome analyses of various species, human population studies, and statistical studies of the predictive utility of animal models). This book comes to the unique conclusion that while animals can be successfully used for many endeavors in science such as basic and comparative research, they cannot be used to predict drug and disease response in humans. The arguments presented are rooted in the history, philosophy, and methodology of biomedical research. This book will be of interest to anyone involved, directly or indirectly, in biomedical research (including physicians, veterinarians and scientists), and anyone interested in the history, philosophy and methodology of science. In contrast to books written by and for the animal rights movement and books written by and for the animal-based research industry, this book honestly examines all sides of the scientific arguments for using animals in science and concludes that each group in turn exaggerates the flaws or strengths of using animals. There are areas in science where animals can be viably used but there are also areas where they cannot be so used. REVIEWS See Philosophies, Ethics, and Humanities in Medicine 17 August 2010
