The Role of Melanin Concentrating Hormone in Central Cardiorespiratory Regulation PDF Download
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Author: Eyitemi Joseph Egwuenu
Publisher:
ISBN:
Category : Cardiopulmonary system
Languages : en
Pages : 241
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Book Description
Author: Eyitemi Joseph Egwuenu
Publisher:
ISBN:
Category : Cardiopulmonary system
Languages : en
Pages : 241
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Book Description
Author: Ningjing Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 300
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Book Description
The lateral hypothalamus is a brain region involved in the regulation of feeding, glucose homeostasis, sleep/wake cycle, and autonomic nervous system (ANS). Melanin concentrating hormone (MCH) containing neurons, located in the lateral hypothalamus, project widely throughout the central nervous system, including the brain regions that are involved in central chemoreception, food intake, and sleep. These neurons also have multisynaptic connections with the phrenic motoneurons and the ANS. My overall hypothesis is that the lateral hypothalamus is a central chemoreceptor site and hypothalamic MCH neurons play a role in central chemoreception, cardiovascular control, and energy balance. Electroencephalogram (EEG) and electromyogram (EMG) electrodes were surgically implanted to record vigilance states. Arterial catheters were implanted for blood pressure and heart rate recordings. Whole body plethysmography was used to measure ventilation and metabolic rate while breathing in room air of 5% CO2. In the first series of experiments, reverse-microdialysis was used to focally deliver artificial cerebrospinal fluid (aCSF) equilibrated with 25% CO2 to perifornical-lateral hypothalamic area (PF-LHA) in conscious rats while breathing in room air. In the second series of experiments, siRNA was used to knock down the expression of the MCH precursor gene (pMCH) to lower the levels of MCH in the brain. In the third series of experiments, acute central injection of MCH was applied in the third ventricle. Focal acidification in the PF-LHA caused an increase in ventilation only during quiet wakefulness, suggesting that the PF-LHA functions as a central chemoreceptor site and does so in a vigilance-state dependent manner. Knockdown of the pMCH expression resulted in an increase in the ventilatory response to 5% CO2 only during quiet wakefulness, accompanied by an increased metabolic rate, a reduced body weight and glucose level, as well as a disturbed sleep-wake cycle. Central injection of MCH induced food and water intake and lowered metabolic rate and blood pressure. Overall, these results indicate that hypothalamic MCH neurons are involved in central chemoreception in wakefulness, and suggest that disturbance of their function could contribute to obesity and obesity-related breathing and metabolic disorders.
Author: Mitchell G. Miglis
Publisher: Academic Press
ISBN: 0128041129
Category : Science
Languages : en
Pages : 270
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Book Description
Sleep and Neurologic Disease reviews how common neurologic illnesses, such as Parkinson's Disease and Alzheimer's dementia impact sleep. In addition, the book discusses how common primary sleep disorders influence neurologic diseases, such as the relationship between obstructive sleep apnea and stroke, as well as their association with various primary headache disorders and epilepsy syndromes. The utilization of sleep technology, such as polysomnography, multiple sleep latency testing, actigraphy, laboratory and CSF testing is also covered. The book is written for the practicing neurologist, sleep physician, neuroscientist, and epidemiologist studying sleep. - Reviews how common neurological illnesses impact sleep and the impact sleep disorders have on neurologic disease - Up-to-date, comprehensive overview written for practicing neurologists, sleep physicians, neuroscientists, and epidemiologists - Includes informative discussions on sleep physiology, circadian rhythms, sleep and stroke, and treatment options for neurologists
Author:
Publisher: ScholarlyEditions
ISBN: 1490110585
Category : Medical
Languages : en
Pages : 1115
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Book Description
Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Experimental Physiology. The editors have built Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Experimental Physiology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Physiology, Cell Biology, and Molecular Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Teri J. Barkoukis
Publisher: Elsevier Health Sciences
ISBN: 1455723304
Category : Health & Fitness
Languages : en
Pages : 817
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Book Description
Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.
Author: S. R. Pandi-Perumal
Publisher: Springer
ISBN: 3319757652
Category : Science
Languages : en
Pages : 236
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Book Description
This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.
Author: Qingchun Tong
Publisher: CRC Press
ISBN: 100036691X
Category : Medical
Languages : en
Pages : 330
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Book Description
This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism. Key Features Explores the role signaling between neurons plays with respect to metabolism Documents how neurotransmitters affect the regulation of feeding Describes various methods and technologies used to study the neuronal control of metabolism Includes contributions from an international team of leading researchers. Related Titles Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5) Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)
Author: E. I. Sokolov
Publisher: VSP
ISBN: 9789067642125
Category : Medical
Languages : en
Pages : 338
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Book Description
This book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.
Author: Stavros Baloyannis
Publisher: BoD – Books on Demand
ISBN: 1789844444
Category : Medical
Languages : en
Pages : 144
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Book Description
The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.
Author: Stuart J. McDougall
Publisher: Frontiers Media SA
ISBN: 2889194752
Category : Disease control
Languages : en
Pages : 94
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Book Description
The field of autonomic neuroscience research concentrates on those neural pathways and processes that ultimately modulate parasympathetic and sympathetic output to alter peripheral organ function. In the following ebook, laboratories from across the field have contributed reviews and original research to summarize current views on the role of the brain in tuning peripheral organ performance to regulate body temperature, glucose homeostasis and blood pressure.
