The Role of Chemokine Receptors in Lymphocyte Trafficking to the Gastrointestinal Tract in Health and in Inflammatory Bowel Disease PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Role of Chemokine Receptors in Lymphocyte Trafficking to the Gastrointestinal Tract in Health and in Inflammatory Bowel Disease PDF full book. Access full book title The Role of Chemokine Receptors in Lymphocyte Trafficking to the Gastrointestinal Tract in Health and in Inflammatory Bowel Disease by Susan Jane Connor. Download full books in PDF and EPUB format.
Author: Susan Jane Connor
Publisher:
ISBN:
Category : Chemokines
Languages : en
Pages : 478
Get Book Here
Book Description
Author: Susan Jane Connor
Publisher:
ISBN:
Category : Chemokines
Languages : en
Pages : 478
Get Book Here
Book Description
Author: Wun Kuk
Publisher:
ISBN:
Category :
Languages : en
Pages : 41
Get Book Here
Book Description
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract including two major categories, Crohn's disease (CD) and ulcerative colitis (UC). Rapid recruitment of lymphocytes from peripheral circulation to the gut mucosa is a key feature of IBD. The process of lymphocytes homing to the gut is a multiple-step adhesion viii cascade that is mediated by adhesion molecules such as integrin [alpha]4[beta]7. Integrin [alpha]4[beta]7 is expressed on lymphocytes and interacts with its ligand, mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), which is primarily expressed in the high endothelial venules in the small intestine, the colon, and Peyer's Patches. Integrin [alpha]4[beta]7 is a therapeutic target in IBD. Clinical studies report that vedolizumab, a humanized antibody against integrin [alpha]4[beta]7, effectively maintains clinical remission in IBD patients. However, aggravated colitis was observed in a small percentage of patients treated with high dose of vedolizumab, which is probably due to aberrant innate immune response to intestinal mucosal injury and infection. Here, the role of integrin [beta]7 on recruiting conventional and regulatory T lymphocytes during intestinal inflammation is further investigated by using two IBD mouse models. Conventional/effector T cells activate other effector immune cells whereas regulatory T cells suppress inflammatory activities and maintain peripheral tolerance. The results demonstrated that deficiency in integrin [beta]7 exacerbates induced spontaneous colitis. The suppression function of [beta]7-deficient Treg cells remains intact. However, integrin [beta]7-deficiency impairs the homing capacity of both regulatory T cells and effector T cells to the GALT. These findings possibly explain the adverse effects seen in high dose vedolizumab treatment, suggesting that excessive blocking of integrin [beta]7 function should be avoided to prevent potential adverse effects of this medication.
Author: Jeffrey K. Harrison
Publisher: Humana Press
ISBN: 9781588297730
Category : Medical
Languages : en
Pages : 403
Get Book Here
Book Description
This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.
Author: Marianne Michelle Stanford
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Alf Hamann
Publisher: John Wiley & Sons
ISBN: 3527607013
Category : Medical
Languages : en
Pages : 557
Get Book Here
Book Description
Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Get Book Here
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: James J. Lee
Publisher: Academic Press
ISBN: 012394385X
Category : Health & Fitness
Languages : en
Pages : 679
Get Book Here
Book Description
Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Author: Thomas T. MacDonald
Publisher: S Karger Ag
ISBN: 9783805567220
Category : Medical
Languages : en
Pages : 241
Get Book Here
Book Description
There are more T cells in the gastrointestinal tract and lung than in the rest of the body combined. The aim of this book is to cover all the important aspects of the biology of these cells in animals and in man. Basic observations are described as well as disease states where aberrant activation of mucosal T cells causes tissue damage. The continuing discovery of features of mucosal T cells which make them different from T cells in the periphery is a consistent theme throughout the text. Topics discussed include new developments in understanding why the characteristic response of mucosal T cells to soluble antigens is tolerance, the role of the gut epithelium in intestinal immunity, the molecular basis by which T cells home to the gut mucosa, the functions of gammadelta T cells, the discovery of a new lymphoid organ - the cryptopatch - in the mouse gut, and the remarkable oligoclonality of the alphabeta and gammadelta T cells in the gut epithelium. In more disease-related sections, the way in which T cells play a role in asthma and protection from parasite infection, and how they cause inflammatory bowel disease in man and animals are described. Providing an excellent survey of the field, this book is a valuable resource for both basic scientists and clinicians interested in intestinal immunology and gastrointestinal disease.
Author: D. Neil Granger
Publisher: Morgan & Claypool Publishers
ISBN: 1615041656
Category : Medical
Languages : en
Pages : 99
Get Book Here
Book Description
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Author: Gerard Socie
Publisher: Academic Press
ISBN: 0128134399
Category : Science
Languages : en
Pages : 430
Get Book Here
Book Description
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
