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Author: Hans Neurath
Publisher: Elsevier
ISBN: 0323161383
Category : Science
Languages : en
Pages : 683
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Book Description
The Proteins: Composition, Structure, and Function, Second Edition, Volume I explores the quantitative relationships between protein composition, structure, and function. This book is composed of six chapters that cover the rapid and fundamental advances in understanding protein chemistry. This book outlines first the quantitative procedures and various methods suitable for the determination of amino acids found as constituents of naturally occurring peptides and as free amino acids in tissues and body fluids. These topics are followed by a discussion on some of the aspects of peptide chemistry, which appear significant in relation to peptides possessing physiological activity. The next chapter considers protein synthesis that represents the sequences of chemical reactions whereby amino acids are assembled in biological systems to produce proteins. This volume also examines the correlation of structure with function; the mechanisms of control of protein biosynthesis; the exact role of intramolecular interactions in the determination of tertiary structure; and the colinearity of genetic "maps with amino acid sequences. A chapter describes the methods of analysis and reactions of sulfhydryl, disulfide, and thiol ester groups in proteins, as well as the evidence relating to the functions of these sulfur groups in proteins. The final chapter looks into the models and theories for the noncovalent bond interactions in proteins. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.
Author: Hans Neurath
Publisher: Elsevier
ISBN: 0323161383
Category : Science
Languages : en
Pages : 683
Get Book Here
Book Description
The Proteins: Composition, Structure, and Function, Second Edition, Volume I explores the quantitative relationships between protein composition, structure, and function. This book is composed of six chapters that cover the rapid and fundamental advances in understanding protein chemistry. This book outlines first the quantitative procedures and various methods suitable for the determination of amino acids found as constituents of naturally occurring peptides and as free amino acids in tissues and body fluids. These topics are followed by a discussion on some of the aspects of peptide chemistry, which appear significant in relation to peptides possessing physiological activity. The next chapter considers protein synthesis that represents the sequences of chemical reactions whereby amino acids are assembled in biological systems to produce proteins. This volume also examines the correlation of structure with function; the mechanisms of control of protein biosynthesis; the exact role of intramolecular interactions in the determination of tertiary structure; and the colinearity of genetic "maps with amino acid sequences. A chapter describes the methods of analysis and reactions of sulfhydryl, disulfide, and thiol ester groups in proteins, as well as the evidence relating to the functions of these sulfur groups in proteins. The final chapter looks into the models and theories for the noncovalent bond interactions in proteins. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.
Author: Bernhard Wunderlich
Publisher: Elsevier
ISBN: 0323145906
Category : Science
Languages : en
Pages : 564
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Book Description
Macromolecular Physics, Volume 1: Crystal Structure, Morphology, Defects provides a unified treatment of crystals of linear macromolecules. This book is organized into four chapters: structure of macromolecules, microscopic structure of crystals, crystal morphology, and defect crystal. This publication specifically discusses the macromolecular hypothesis, molecular conformation, and synthesis of macromolecules. The discovery and proof of the lattice theory, structures of minimum free energy, and crystal structures of macromolecules are also deliberated. This publication likewise covers the macromolecular crystals, macroscopic recognition of defects, and deformation of polymer crystals. This volume is a good reference for physicists, scientists, and specialists concerned with research on crystals of linear macromolecules.
Author: Andrzej Kloczkowski
Publisher: Humana
ISBN: 9781071641958
Category : Science
Languages : en
Pages : 0
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Book Description
This second edition volume expands on the previous edition with updates on the latest methods, resources, and studies concerning analysis and prediction of various structural and functional aspects of proteins and ncRNAs. The chapters in this book cover topics such as secondary structure characterization and prediction; the use and impact of AI (including AlphaFold, large language models, and deep neural networks) in the protein structure prediction field; methods and resources for the prediction of posttranslational modifications, residue-residue contacts, subcellular localization, intrinsic disorder, protein-ligand interactions, and protein aggregation; analysis of cryo-EM data; and analysis of noncoding RNAs in the context of human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions and surveys of the respective topics, list the necessary materials and methods, cover step-by-step instructions on how to use predictive tools and interpret their results, and provide tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Prediction of Protein Secondary Structure, Second Edition is a valuable resource for anyone interested in understanding the dynamic and growing field of the protein structure prediction.
Author: Thomas Pfannschmidt
Publisher: Frontiers Media SA
ISBN: 2889199274
Category : Botany
Languages : en
Pages : 113
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Book Description
Plastids are plant cell-specific organelles of endosymbiotic origin that contain their own genome, the so-called plastome. Its proper expression is essential for faithful chloroplast biogenesis during seedling development and for the establishment of photosynthetic and other biosynthetic functions in the organelle. The structural organisation, replication and expression of this plastid genome, thus, has been studied for many years, but many essential steps are still not understood. Especially, the structural and functional involvement of various regulatory proteins in these processes is still a matter of research. Studies from the last two decades demonstrated that a plethora of proteins act as specific regulators during replication, transcription, post-transcription, translation and post-translation accommodating a proper inheritance and expression of the plastome. Their number exceeds by far the number of the genes encoded by the plastome suggesting that a strong evolutionary pressure is maintaining the plastome in its present stage. The plastome gene organisation in vascular plants was found to be highly conserved, while algae exhibit a certain flexibility in gene number and organisation. These regulatory proteins are, therefore, an important determinant for the high degree of conservation in plant plastomes. A deeper understanding of individual roles and functions of such proteins would improve largely our understanding of plastid biogenesis and function, a knowledge that will be essential in the development of more efficient and productive plants for agriculture. The latter represents a major socio-economic need of fast growing mankind that asks for increased supply of food, fibres and biofuels in the coming decades despite the threats exerted by global change and fast spreading urbanisation.
Author: Engelbert Buxbaum
Publisher: Springer
ISBN: 331919920X
Category : Science
Languages : en
Pages : 521
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Book Description
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Author: S Bresler
Publisher: Elsevier
ISBN: 0323145590
Category : Science
Languages : en
Pages : 573
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Book Description
Introduction to Molecular Biology focuses on the principles of polymer physics and chemistry and their applications to fundamental phenomena in biological sciences. It examines the structure, synthesis, and function of nucleic acids and proteins, as well as the physicochemical techniques necessary in determining the macromolecular structure, the kinetics and mechanism of enzyme action, the genetics of bacteria and their viruses, and the genetic code. It also considers the importance of precise quantitative analysis in biochemistry and biophysics, the architecture and function of biological macromolecules, and the unique mechanisms that regulate the cell's biological activity. Organized into five chapters, this book begins with an overview of proteins and their functional activity, from contractility and enzymatic catalysis to immunological activity, formation of selectively permeable membranes, and reversible binding and transport. It explains how such functions are related to molecular interactions and therefore fall within the purview of molecular biology. The book then proceeds with a discussion on the chemical structure of proteins and nucleic acids, the physicochemical techniques in measuring molecular size and shape, the mechanism of enzymatic reactions, the functions of DNA and RNA, and the mechanism of phase transition in polynucleotides. This book is intended for both biologists and non-biologists who want to be acquainted with the advances made in molecular biology, molecular genetics, and molecular biophysics during the 1950s and 1960s.
Author: Karl Esser
Publisher: Springer Science & Business Media
ISBN: 3642558194
Category : Science
Languages : en
Pages : 545
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Book Description
With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on genetics, cell biology, physiology, comparative morphology, systematics, ecology, and vegetation science.
Author: Rogier M. Reijmers
Publisher: Frontiers Media SA
ISBN: 2889662535
Category : Medical
Languages : en
Pages : 234
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Michael I. Page
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 576
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Book Description
Theories of enzyme catalysis. Enzyme models - synthetic polymers. Enzyme models - crown ethers. Enzyme models - cyclodextrins (cycloamyloses). Enzyme models - small molecule and intramolecular catalysis. Use of protein engineering to study enzyme mechanisms. Transition state affinity and the design of enzyme inhibitors. Acyl group transfer -fundamental mechanisms, cysteine proteinases, the serine proteinases, phosphoryl transfer, sulphotransferases and sulphatases, aspartic proteinases, metalloproteinases. Glycosil group transfer. Isomerization mechanisms through hydrogem and carbon transfer. Imine formation in enzimatic reactions. Pyridoxal phosphate dependent enzymes. Thiamine-depedent enzymes. Adenosylcobalamin-dependent enzymic reactions. Folate-dependent enzymes. Glutathione-dependent enzymes-chemistry. Glutathione-dependent enzymes - glutathione-S-transferases. Oxido-reductases - pyridine nucleotide-dependent enzymes. Oxido-reductases - flavoenzymes. Multi-enzyme complexes - Eukaryotic fatty acid synthases.
Author: Franck Carbonero
Publisher: Frontiers Media SA
ISBN: 2832501508
Category : Science
Languages : en
Pages : 244
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Book Description
