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Author: Roberto Abadie
Publisher: Duke University Press Books
ISBN: 9780822348146
Category : Social Science
Languages : en
Pages : 0
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Book Description
The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.
Author: Roberto Abadie
Publisher: Duke University Press Books
ISBN: 9780822348146
Category : Social Science
Languages : en
Pages : 0
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Book Description
The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.
Author: Roberto Abadie
Publisher: Duke University Press
ISBN: 0822393247
Category : Social Science
Languages : en
Pages : 199
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Book Description
The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.
Author: Jim Endersby
Publisher: Harvard University Press
ISBN: 9780674027138
Category : Science
Languages : en
Pages : 544
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Book Description
"Endless forms most beautiful and most wonderful have been, and are being, evolved," Darwin famously concluded The Origin of Species, and for confirmation we look to...the guinea pig? How this curious creature and others as humble (and as fast-breeding) have helped unlock the mystery of inheritance is the unlikely story Jim Endersby tells in this book. Biology today promises everything from better foods or cures for common diseases to the alarming prospect of redesigning life itself. Looking at the organisms that have made all this possible gives us a new way of understanding how we got here--and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, offers a bird's (or rodent's) eye view of the work that makes science possible. Mixing the celebrities of genetics, like the fruit fly, with forgotten players such as the evening primrose, the book follows the unfolding history of biological inheritance from Aristotle's search for the "universal, absolute truth of fishiness" to the apparently absurd speculations of eighteenth-century natural philosophers to the spectacular findings of our day--which may prove to be the absurdities of tomorrow. The result is a quirky, enlightening, and thoroughly engaging perspective on the history of heredity and genetics, tracing the slow, uncertain path--complete with entertaining diversions and dead ends--that led us from the ancient world's understanding of inheritance to modern genetics.
Author: M. H. Pappworth
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Carl Elliott
Publisher: Beacon Press
ISBN: 0807061441
Category : Medical
Languages : en
Pages : 233
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Book Description
By New Yorker and Atlantic writer Carl Elliott, a readable and even funny account of the serious business of medicine. A tongue-in-cheek account of the changes that have transformed medicine into big business. Physician and medical ethicist Carl Elliott tracks the new world of commercialized medicine from start to finish, introducing the professional guinea pigs, ghostwriters, thought leaders, drug reps, public relations pros, and even medical ethicists who use medicine for (sometimes huge) financial gain. Along the way, he uncovers the cost to patients lost in a health-care universe centered around consumerism.
Author: Colleen AF Venable
Publisher: Graphic Universe ™
ISBN: 1467735027
Category : Juvenile Fiction
Languages : en
Pages : 52
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Book Description
Sasspants, PI(G), the world's fluffiest detective, is back on the case?or she will be, if her sidekick Hamisher can convince her there's really a mystery afoot. Hamisher has made up so many stories, Sasspants doesn't believe him. But one by one the mice in Mr. Venezi's pet shop are going missing, and all the spooky clues point to...a ghost! Once our shaggy Sherlocks start digging for answers, they will stop at nothing to ferret out the truth!
Author: Colleen AF Venable
Publisher: Graphic Universe ™
ISBN: 1467735000
Category : Juvenile Fiction
Languages : en
Pages : 52
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Book Description
There's a sandwich thief in Mr. Venezi's pet shop. Everyone is a suspect, from the chinchillas to the goldfish. Never fear! The world's fluffiest detective on the case: Sasspants, PI(G). By day, Sasspants is your average book-loving, gizmo-inventing guinea pig. By night she solves pet shop mysteries with the help of her sidekick, Hamisher the hamster. Our furry little heroes will stop at nothing to find the sandwich thief! This is the first book in the Guinea PIG, Pet Shop Private Eye series. "Absolutely adorable drawings, blended with witty dialogue in a way that makes this comic a perfect read for all ages . . . and Owly would like to add that 'little Hamisher and his drawings are equal to awesome.'"—Andy Runton, author of Owly "Move over Miss Marple, never mind the No. 1 Ladies' Detective Agency, here's the real mistress of the whodunit. She's sharp. And she's furry. This one's a keeper."—Mark Siegel, illustrator of To Dance: A Ballerina's Graphic Novel
Author: Virginia Parker Guidry
Publisher: Fox Chapel Publishing
ISBN: 1937049078
Category : Pets
Languages : en
Pages : 145
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Book Description
“Compact, easy-to-care-for, and a bundle of fun” is how author Virginia Parker Guidry describes the irresistible guinea pig. Ideal pets for families with children, cavies (as they’re often called) are clean, odorless, gentle, loving, and entertaining. This Complete Care Made Easy Guinea Pigs encapsulates all the virtues of these perfect small mammals and gives new owners practical advice about how to care for them. In chapter one, “A Guinea What?” the author talks about the guinea pig’s natural history—they’re neither pigs nor from Guinea, but rather a rodent from Peru—and how scientists classify this very unique mammal. To decide whether the guinea pig is right for you, chapter two discusses who makes the ideal owner and presents thirteen popular breeds of longhaired and shorthaired guinea pigs and the colors available to pet owners today. The chapter “Finding a Healthy Guinea Pig” offers solid advice about selecting the right guinea pig, where to purchase or adopt, and the preferred sex. A complete chapter on preparing for the guinea pig offers the reader excellent advice about acclimating the new pet to the home, selecting the best cage and hutch, and pig-proofing the home. The subject of understanding guinea pig behavior is discussed in the chapter “Living with a Guinea Pig,” which also covers daily-care topics such as feeding, grooming, handling, exercise, and litter box training. Keeping the guinea pig healthy is discussed in “Staying Healthy,” a chapter that covers preventing illness, choosing a veterinarian, and common ailments. The final chapter “Just for the Fun of It!” explores games, toys, activities, and showing guinea pigs. The appendix includes lists of pig-specific clubs, organizations, and websites. Glossary of terms and index included.
Author: Heather Dubrow
Publisher: Ghost Mountain Books
ISBN: 1939457548
Category : Health & Fitness
Languages : en
Pages : 269
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Book Description
Author: Donna J. Clemons
Publisher: CRC Press
ISBN: 1000218759
Category : Medical
Languages : en
Pages : 179
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Book Description
Laboratory animals play an important role in biomedical research and advances. Expanded, updated, and now published in full color to provide greater clarity to the techniques and concepts discussed, this guide presents basic information and common procedures in detail to provide a quick reference for investigators, technicians, and caretakers in the laboratory setting. It includes additional information on the research uses of the guinea pig along with updated medical care information.
