The Molecular Basis of Mutation PDF Download
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Author: John W Drake
Publisher:
ISBN: 9784871871563
Category : Science
Languages : en
Pages : 288
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Book Description
This book offers the first extensive introduction to mutational mechanisms, one of the most rapidly progressing and fruitful areas of molecular biology. It presents a broad outline of present knowledge while emphasizing many of the doubtful areas. The discussion is primarily concerned with mutation in prokaryotic microorganisms, because most of the early conceptual advances in molecular genetics arose from studies on these forums. Great emphasis is placed on bacteriophage systems, since these have been the most revealing in the development of current theory and description. A brief introduction to the structure, replication and genetics of viruses is provided. The effects of mutation on gene action are briefly considered in chapters on suppression and on polarity and complementation. This book is heavily referenced with investigators names appearing in the body of the book. Extensive use is made of the explanatory figures and suggestions for future investigations are frequently provided. The book is designed to appeal to graduate students and professional investigators (especially those entering the field of molecular biology from other disciplines). No detailed knowledge of genetics or biochemistry is assumed. John W. Drake is an American microbiologist, working for over half a century in the field of mutagenesis and DNA repair.
Author: John W Drake
Publisher:
ISBN: 9784871871563
Category : Science
Languages : en
Pages : 288
Get Book Here
Book Description
This book offers the first extensive introduction to mutational mechanisms, one of the most rapidly progressing and fruitful areas of molecular biology. It presents a broad outline of present knowledge while emphasizing many of the doubtful areas. The discussion is primarily concerned with mutation in prokaryotic microorganisms, because most of the early conceptual advances in molecular genetics arose from studies on these forums. Great emphasis is placed on bacteriophage systems, since these have been the most revealing in the development of current theory and description. A brief introduction to the structure, replication and genetics of viruses is provided. The effects of mutation on gene action are briefly considered in chapters on suppression and on polarity and complementation. This book is heavily referenced with investigators names appearing in the body of the book. Extensive use is made of the explanatory figures and suggestions for future investigations are frequently provided. The book is designed to appeal to graduate students and professional investigators (especially those entering the field of molecular biology from other disciplines). No detailed knowledge of genetics or biochemistry is assumed. John W. Drake is an American microbiologist, working for over half a century in the field of mutagenesis and DNA repair.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309134404
Category : Science
Languages : en
Pages : 270
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Book Description
In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.
Author: Masatoshi Nei
Publisher: OUP Oxford
ISBN: 0199661731
Category : Science
Languages : en
Pages : 261
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Book Description
The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.
Author: Rodney Mauricio
Publisher: Springer Science & Business Media
ISBN: 1402038364
Category : Science
Languages : en
Pages : 207
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Book Description
An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized "many slight differences" as the ultimate source of variation to be acted upon by natural selection. In the early 1900’s, this view was opposed by "Mendelian geneticists", who emphasized the importance of "macromutations" in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.
Author: Charles R. Scriver
Publisher: New York ; Montreal : McGraw-Hill
ISBN: 9780071363198
Category : Genetic disorders
Languages : en
Pages : 6338
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Book Description
Presents clinical, biochemical, and genetic information concerning those metabolic anomalies grouped under inborn errors of metabolism.
Author: William B. Coleman
Publisher: Academic Press
ISBN: 0128027878
Category : Medical
Languages : en
Pages : 805
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Book Description
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase
Author: Richard Kowles
Publisher: Springer Science & Business Media
ISBN: 1461302056
Category : Medical
Languages : en
Pages : 489
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Book Description
Helping undergraduates in the analysis of genetic problems, this work emphasizes solutions, not just answers. The strategy is to provide the student with the essential steps and the reasoning involved in conducting the analysis, and throughout the book, an attempt is made to present a balanced account of genetics. Topics, therefore, center about Mendelian, cytogenetic, molecular, quantitative, and population genetics, with a few more specialized areas. Whenever possible, the student is provided with the appropriate basic statistics necessary to make some the analyses. The book also builds on itself; that is, analytical methods learned in early parts of the book are subsequently revisited and used for later analyses. A deliberate attempt is made to make complex concepts simple, and sometimes to point out that apparently simple concepts are sometimes less so on further investigation. Any student taking a genetics course will find this an invaluable aid to achieving a good understanding of genetic principles and practice.
Author: Timothy Graubert
Publisher:
ISBN: 9780982843512
Category : Hematology
Languages : en
Pages : 637
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Book Description
Hematologists and others working in hematology-related fields need to stay current with the latest advances in the rapidly evolving disciplines of adult and pediatric hematology. The American Society of Hematology Self-Assessment Program (ASH-SAP) is the only complete, comprehensive, educational resource available that fulfills this need, while also providing thorough board and recertification preparation, as well as AMA PRA Category 1 Credit'.
Author: Esteban Domingo
Publisher: Academic Press
ISBN: 0128163321
Category : Science
Languages : en
Pages : 428
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Book Description
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes
